Navigation Links
Children's Hospital study demonstrates how bone marrow transplant can cure sickle cell disease
Date:11/7/2008

A unique approach to bone marrow transplantation pioneered in part by a Children's Hospital of Pittsburgh of UPMC physician has proven to be the only safe and effective cure for sickle cell disease, according to a new study.

Lakshmanan Krishnamurti, MD, a pediatric hematologist/oncologist at Children's Hospital, helped pioneer a form of bone marrow transplantation which relies on reduced-intensity conditioning (RIC). RIC regimens are less toxic to patients and therefore can be offered to patients with severe sickle cell disease because they eliminate life-threatening side effects generally associated with bone marrow transplantation.

In a study published in the November issue of the journal Biology of Blood and Marrow Transplantation, Dr. Krishnamurti and colleagues report that six of seven sickle cell patients who received RIC bone marrow transplants in the last decade now have donor marrow and are free from symptoms of their sickle cell disease. Dr. Krishnamurti led five of the seven transplants in the study.

"Bone marrow transplant is the only known cure for sickle cell disease. But doctors have avoided performing them in these patients because complications from a traditional bone marrow transplant can be life-threatening," said Dr. Krishnamurti, director of the Sickle Cell Program at Children's Hospital. "Through the reduced-intensity approach we developed, the potential for complications is dramatically lessened. This study offers hope for a cure to thousands of patients with severe sickle cell disease."

Traditionally, bone marrow transplants require heavy doses of chemotherapy prior to transplant in order to destroy the recipient's bone marrow so it will not reject the donated marrow. But with their bone marrow destroyed, transplant recipients become vulnerable to life-threatening complications, a risk viewed as unnecessary because sickle cell disease is not typically immediately life-threatening.

Dr. K
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nautica Malibu Triathlon Presented by Toyota Raises $718,000 for Childrens Hospital Los Angeles Pediatric Cancer Research
2. Childrens Hospital Los Angeles Turns Off the Tap With Green Earth Waterless Carwash
3. Siegel+Gale Designs New HOPE Portal for Childrens Hospital Los Angeles
4. New research explores newborn in-hospital weight loss
5. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
6. Norwalk virus: Cruise ship illness challenging and costly to hospitals, too
7. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
8. Billy Graham Home After Hospitalization:
9. Alvarado Hospital Files Countersuit Against Blue Shield
10. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
11. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... genetic variant specifically associated with the risk of ... per cent of all breast cancer cases. , ... sub-type, called invasive lobular carcinoma, gives researchers important ... kind of breast cancer, which can be missed ... in the journal PloS Genetics , was ...
(Date:4/17/2014)... Researchers at the University of California, San Diego School ... those who have suffered a recent major loss are ... older adults. , The study is published in this ... Psychiatry . , Because compassionate behaviors are associated with ... findings offer insights into ways to improve the outcomes ...
(Date:4/17/2014)... New Rochelle, NY, April 17, 2014U.S. military personnel ... "blast plus impact" concussive traumatic brain injury (TBI) ... were evacuated for other medical reasons. Differences in ... and depression 6-12 months after injury are reported ... , a peer-reviewed journal from Mary Ann Liebert, ...
(Date:4/17/2014)... 2014 By discovering a new mechanism that allows ... researchers at UC Irvine and the Salk Institute have ... or prevent stroke-induced brain damage. , A complex and ... death and primary reason for disability in the U.S. ... and lets blood-borne material into the brain, causing the ...
(Date:4/17/2014)... An international research team led by Cesar A. Arias, ... Center at Houston (UTHealth) has identified a new superbug ... The report appeared in the April 17 issue of ... The new superbug is part of a class of ... or MRSA, which is a major cause of hospital ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:The ilk of human kindness 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:New MRSA superbug emerges in Brazil 2
... 18 Nuvilex, Inc. (OTC Bulletin Board: NVLX), ... marketing initiatives designed to raise visibility of two of ... among the key 18 to 25 year old demographic ... 28th, expertly trained marketing and sales teams will be ...
... solutions provider ICW celebrates its opening in Canada ... Gingrich, Founder of the Center for Health Transformation and ... McKenna, Deputy Chair of TD Bank Financial Group and ... eHealth specialist InterComponentWare AG (ICW), will celebrate the launch ...
... highs , , WEDNESDAY, March 18 (HealthDay News) -- The number ... record level in the United States, and Cesarean delivery rates ... The total number of births, birth rate and proportion of ... 5 percent from 2006 to 2007. The estimated 1,714,643 babies ...
... announced that it has again received the World Wide ... Information Resource Center. Imaginis received a merit rating for ... period of Spring/Summer 2008. This is the fifth ... The WWW Health Awards program recognizes the best health ...
... Executive Search for Replacement is CompletedPlanned Investor Conference ... 4:15 PM ET LIVINGSTON, N.J., March 18 ... the recognized leader in advanced injection technologies, today ... will temporarily assume the post of Interim Chief ...
... Emphasis needed on improving policy, practice and personal skillsWASHINGTON, ... non-profit National Council on Aging (NCOA), with support from ... reveals a bleak and broken health care system for ... conditions. The results of the Re-Forming Health Care: ...
Cached Medicine News:Health News:Nuvilex, Inc. Launches Spring Break Initiatives Designed to Raise Visibility Among Key Demographic Group 2Health News:Nuvilex, Inc. Launches Spring Break Initiatives Designed to Raise Visibility Among Key Demographic Group 3Health News:Gingrich and McKenna to Speak on Transformation of Healthcare Delivery at ICW Launch 2Health News:Unmarried Childbirths in U.S. Reach Record Levels 2Health News:Milestone Scientific Announces Resignation of CEO 2Health News:Milestone Scientific Announces Resignation of CEO 3Health News:Video: NCOA Issues Call-to-Action for National Chronic Care Reform Based on Results of Comprehensive Survey of Americans with Chronic Conditions 2Health News:Video: NCOA Issues Call-to-Action for National Chronic Care Reform Based on Results of Comprehensive Survey of Americans with Chronic Conditions 3Health News:Video: NCOA Issues Call-to-Action for National Chronic Care Reform Based on Results of Comprehensive Survey of Americans with Chronic Conditions 4
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Delivery Systems -- Focus on End Users ... STUDY OBJECTIVES A drug delivery ...
(Date:1/14/2014)... (Nasdaq: LMNX ) today announced that it expects ... Monday, February 3, 2014. A press release announcing the results ... (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) Management will ... financial results for the fourth quarter and twelve months ended ...
(Date:1/14/2014)... 2014 Animal Emergency Critical Care, a LifeCentre partner practice, located ... is the first in Loudoun County ... Dr. Susan M. Barnes , Medical Director, is a well-seasoned ... Cole Taylor , are avid scuba divers. "As altitude skiers ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2
... 2012  Boston Scientific Corporation (NYSE: BSX ) ... Morgan Healthcare Conference in San Francisco. Hank ... the Company on Wednesday, January 11, 2012, beginning at ... Mahoney, President, and Jeff Capello, Executive Vice President and ...
... 2012  Mettler-Toledo International Inc. (NYSE: MTD ) today ... Healthcare Conference in San Francisco on Tuesday, January 10, 2012, ... hear a live webcast of the presentation, visit the investor ... .  A replay of the webcast will be available for ...
Cached Medicine Technology:Boston Scientific to Participate in 30th Annual J.P. Morgan Healthcare Conference 2
The Nordt Knot Tightener allows both pushing and spreading of knots, reproducing identical techniques,used when tying traditional open knots. The Nordt Knot Tightener allows tying of any type of s...
Single step suture passage is made simple with Arthro-Pierce instruments. The low profile, highly sharpened tip allows easy passage through tissue in order to retrieve or apply suture....
12" suture passer...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
Medicine Products: