Navigation Links
Children's Hospital researchers identify molecular 'switch' that could save very young lives
Date:12/4/2007

A team of researchers at Childrens Hospital of Pittsburgh of UPMC have identified a molecular switch that, when blocked, may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature infants.

Results of the research were presented by principal investigator David J. Hackam, MD, PhD, a pediatric surgeon and scientist at Childrens Hospital, this weekend at the 4th Annual Meeting of the American Society for Cell Biology.

NEC is a severe inflammatory disease of the intestine that occurs in about 5 percent of premature births and can be fatal in as many as half of those cases. In extreme cases, NEC leads to perforation of the intestine, a condition that can be fatal if not treated with emergency surgery. NEC is increasing in frequency due to the increased survival of premature infants, according to Dr. Hackam.

Working in the laboratory with an animal model of NEC, Dr. Hackams team found that when molecular receptor known as Toll-like receptor-4 (TLR4) was blocked, they enabled the repair of damaged intestinal tissue that is the hallmark of NEC.

This Toll-like receptor is a defense mechanism that normally switches on the intestines immune response. But in some premature infants, stresses like oxygen deprivation and toxins caused by underdeveloped lungs stimulate the overproduction of TLR4. Like an unstoppable alarm, this signaling eventually can lead to cell death and prevent enterocytes from migrating to close wounds in the intestine, which can result in intestinal failure, Dr. Hackam said. By interfering with the production of another molecule associated with TLR4 known as focal adhesion kinase (FAK), we were able to silence the TLR4 alarm in intestinal cells.

Blocking the TLR4 signal allowed enterocytes to once again migrate and heal the damaged intestinal tissue. Dr. Hackams team is continuing to research the development of treatment strategies that would block the TLR4 switch by influencing it
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Nautica Malibu Triathlon Presented by Toyota Raises $718,000 for Childrens Hospital Los Angeles Pediatric Cancer Research
2. Childrens Hospital Los Angeles Turns Off the Tap With Green Earth Waterless Carwash
3. New research explores newborn in-hospital weight loss
4. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
5. Norwalk virus: Cruise ship illness challenging and costly to hospitals, too
6. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
7. Billy Graham Home After Hospitalization:
8. Alvarado Hospital Files Countersuit Against Blue Shield
9. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
10. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
11. Annual flu shot cuts need for doctors visits, hospitalization among children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... (PRWEB) May 25, 2013 On May 20, ... people do not wish to discuss or plan for their ... FuneralFinancials.com released a Must-Do List to help ... Funeral Financials recommends, “Creating a personal fact sheet.” , While ... organize financial information and personal data. It may include ...
(Date:5/25/2013)... NY (PRWEB) May 25, 2013 On ... to brain cancer research and advocacy, comments on a ... Physics, that shows incorporating cold atmospheric plasma into brain ... , According to a Science Daily ... Physics (MPE), biologists and physicians demonstrated the “synergistic effect ...
(Date:5/25/2013)... According to world-renowned scholars, Queen Cleopatra VII ... that ever lived. Cleopatra’s legendary beauty moved nations and ... powerful men in her time. Cleopatra was also a ... skin glowing and fresh, from her legendary milk baths ... and cyprus grass. , Cleopatra was said to possess ...
(Date:5/25/2013)... Prairie Living at Chautauqua , a BMA ... Cross Blood Drive from 1:30 to 5:30 p.m. on ... at 955 Villa Ct. in Carbondale, Illinois, serves older ... need some help to maintain their independence.. , "Come ... Frey, Director of Marketing for Prairie Living. , For ...
(Date:5/25/2013)... 25, 2013 Superior Magnetics for Pain ... in seconds for arthritis, tendinitis and bursitis , Pain ... relief products announced a magnetic bracelet so ... for pain relief is demonstrated at fairs and festivals. ... Gauss magnets and has customers often report pain relief ...
Breaking Medicine News(10 mins):Health News:FuneralFinancials.com Releases Last Wishes Must-Do List 2Health News:Voices Against Brain Cancer Comments on Study that Shows Cold Plasma’s Success Against Brain Cancer Cells 2Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 2Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 3Health News:Carbondale Affordable Assisted Living Community to Host Red Cross Blood Drive 2Health News:Magnetic bracelet relieves pain in seconds announces Superior Magnetics 2
... Dietary Supplement, a product containing the drug estazolam, which might ... few months. // ,Estazolam belongs to benzodiazepines class ... prescription as it may have a number of side effects ... it is not legal to sell it in Canada. ...
... has been a major outbreak of pneumonia in the Downtown ... ,The outbreak in the Downtown Eastside has clearly ... ,In a November 30 memo, David Butcher, vice-president ... that the Vancouver outbreak was severely limiting the availability of ...
... weekend night over, ice has become an integral part of the ... used by people along with ice are marijuana, ketamine, heroin and ... the effects of these drugs when they have report to work. ... sensation in my head, after which they usually smoke ice to ...
... two different proteins taken from primary tumor biopsies is ... lymph nodes, according to researchers who// say this protein ... patients whose disease is likely to metastasize. ... researchers say over-expression of one unidentified protein and under-expression ...
... of senior scientists warns that many tests of drugs on animals// ... will work on humans. ,The British Medical Journal (BMJ) ... that animal studies agreed with human trials in just three areas ... high-profile London drug trial that left six men ill early this ...
... people with history of unprotected sex to have an ... transmission.// The announcement being the first case of such ... Thursday uncovered two clusters of HIV infections, HIV-1 subtype ... government scientists. They said that both the clusters found ...
Cached Medicine News:Health News:Researchers Find Two Biomarkers With Potential to Predict Breast Cancer Spread 2Health News:Researchers Find Two Biomarkers With Potential to Predict Breast Cancer Spread 3Health News:Researchers Find Two Biomarkers With Potential to Predict Breast Cancer Spread 4Health News:Many Drug Tests on Animals are Badly Flawed, a Study Warns 2
(Date:5/24/2013)... LOS ANGELES , May 24, 2013  An ... gathered on Saturday, May 18, in Santa ... findings on new lung-sparing therapies for MPM, a rare ... and commonly affects the pleura, the lining of the ... Heart, Lung and Blood Institute, the 3rd Annual International ...
(Date:5/24/2013)... 24, 2013 In accordance with Rule 17.1 and ... of the United States Exchange Act, Echo Pharma Acquisition Limited ... Elan Corporation (NYSE: ELN). Background On ... an offer for the entire of the issued and to ... "Original Offer").  On 20 May 2013, Royalty ...
(Date:5/23/2013)... 24, 2013 3SBio Inc. (NASDAQ: ... leading China -based biotechnology company ... products, announced today that, at an extraordinary general ... voted in favor of the proposal to authorize ... of merger dated February 8, 2013, among Decade ...
Breaking Medicine Technology:International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 2Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 4Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 5Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 6Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 7Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 8Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 93SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3
... , GLENVIEW, Ill. , Feb. 11 ... to announce the recipients of this year,s Presidential Commendations and Awards ... Gallagher , MD, MPH . This year,s recipients were recognized at ... week, where more than 800 scientists and physicians convened to learn ...
... , , NEW YORK , Feb. 11 ... telecommunication firms are strategically poised to capitalize on rapid ... are increasingly looking for innovative ways to collaborate with ... patients. Despite near universal agreement among pharmaceutical industry executives ...
Cached Medicine Technology:The American Academy of Pain Medicine Announces this Year's Presidential Commendations and Awards 2The American Academy of Pain Medicine Announces this Year's Presidential Commendations and Awards 3The American Academy of Pain Medicine Announces this Year's Presidential Commendations and Awards 4Creative Alliances with Nontraditional Players Increasingly Essential for Survival in Pharmaceutical Industry, New Ernst & Young Report Finds 2Creative Alliances with Nontraditional Players Increasingly Essential for Survival in Pharmaceutical Industry, New Ernst & Young Report Finds 3Creative Alliances with Nontraditional Players Increasingly Essential for Survival in Pharmaceutical Industry, New Ernst & Young Report Finds 4Creative Alliances with Nontraditional Players Increasingly Essential for Survival in Pharmaceutical Industry, New Ernst & Young Report Finds 5
We offer small and large pre-gelled Surface Electrodes suitable for EGG or EMG recordings. Surface Electrodes, Skin Preparation and Conductive Cream complete the setup for a EGG study and are essenti...
We offer small and large pre-gelled Surface Electrodes suitable for EGG or EMG recordings. Surface Electrodes, Skin Preparation and Conductive Cream complete the setup for a EGG study and are essenti...
Sandhill Scientific offers a comprehensive selection of solid state and water perfused catheters for both adult & pediatric applications.Contact Sandhill Scientific for full details...
Each solid state catheter kit below is supplied with adapter cable(s) for Polygraf ID and a Manometric Calibrator....
Medicine Products: