Navigation Links
Children's Hospital researchers identify molecular 'switch' that could save very young lives
Date:12/4/2007

A team of researchers at Childrens Hospital of Pittsburgh of UPMC have identified a molecular switch that, when blocked, may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature infants.

Results of the research were presented by principal investigator David J. Hackam, MD, PhD, a pediatric surgeon and scientist at Childrens Hospital, this weekend at the 4th Annual Meeting of the American Society for Cell Biology.

NEC is a severe inflammatory disease of the intestine that occurs in about 5 percent of premature births and can be fatal in as many as half of those cases. In extreme cases, NEC leads to perforation of the intestine, a condition that can be fatal if not treated with emergency surgery. NEC is increasing in frequency due to the increased survival of premature infants, according to Dr. Hackam.

Working in the laboratory with an animal model of NEC, Dr. Hackams team found that when molecular receptor known as Toll-like receptor-4 (TLR4) was blocked, they enabled the repair of damaged intestinal tissue that is the hallmark of NEC.

This Toll-like receptor is a defense mechanism that normally switches on the intestines immune response. But in some premature infants, stresses like oxygen deprivation and toxins caused by underdeveloped lungs stimulate the overproduction of TLR4. Like an unstoppable alarm, this signaling eventually can lead to cell death and prevent enterocytes from migrating to close wounds in the intestine, which can result in intestinal failure, Dr. Hackam said. By interfering with the production of another molecule associated with TLR4 known as focal adhesion kinase (FAK), we were able to silence the TLR4 alarm in intestinal cells.

Blocking the TLR4 signal allowed enterocytes to once again migrate and heal the damaged intestinal tissue. Dr. Hackams team is continuing to research the development of treatment strategies that would block the TLR4 switch by influencing it
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nautica Malibu Triathlon Presented by Toyota Raises $718,000 for Childrens Hospital Los Angeles Pediatric Cancer Research
2. Childrens Hospital Los Angeles Turns Off the Tap With Green Earth Waterless Carwash
3. New research explores newborn in-hospital weight loss
4. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
5. Norwalk virus: Cruise ship illness challenging and costly to hospitals, too
6. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
7. Billy Graham Home After Hospitalization:
8. Alvarado Hospital Files Countersuit Against Blue Shield
9. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
10. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
11. Annual flu shot cuts need for doctors visits, hospitalization among children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... (PRWEB) April 01, 2015 Phybridge ... solutions infrastructure, announced today its strategic partnership with ... voice solutions to the businesses of Saskatchewan. SaskTels’ ... changing cross-platform application that offers users a hosted ... collaboration tools. The objective of IBC is ...
(Date:4/1/2015)... 2015 Amada Senior Care , premier ... recently opened a new office in Rocky Mount, NC – ... Lee Bissett decided to make the move to senior care ... over 20 years of experience in management and consulting. Their ... , When asked what makes Amada different from other ...
(Date:4/1/2015)... 2015 TCS Healthcare Technologies (TCS), a ... care management and population health arenas, is pleased to ... Connect, which is fully integrated with the ACUITY platform. ... 1:30 p.m. ET, will be led by Jeff Frater, ... will explore the feature-rich portal as well as the ...
(Date:4/1/2015)... April 01, 2015 Enterprise Integration ... Global Edition, a distinguished list and report identifying ... The complete 501 list is currently available on ...     The top ranked MSPs in North America , ... and Africa ,     The top MSPs in ...
(Date:3/31/2015)... 2015 As the demand for optimized ... to have a mobile-friendly website online sometime during the ... Chunk Fitness’ continued commitment to bring the best and ... All of the same great fitness information at ... substantially easier to read while browsing on a mobile ...
Breaking Medicine News(10 mins):Health News:Phybridge and SaskTel Team Up to Eliminate Network Barriers for IP Telephony and Unified Communications Migration 2Health News:Phybridge and SaskTel Team Up to Eliminate Network Barriers for IP Telephony and Unified Communications Migration 3Health News:Amada Senior Care Expands to Eastern North Carolina 2Health News:TCS Healthcare Technologies Releases Acuity Connect 2Health News:TCS Healthcare Technologies Releases Acuity Connect 3Health News:Penton Technology Names Enterprise Integration to the MSPmentor 501 Global Edition 2Health News:Penton Technology Names Enterprise Integration to the MSPmentor 501 Global Edition 3
... injection leads to dependent behavior , , THURSDAY, May 28 ... role in the disrupted functioning of the brain,s reward ... says a new study. , "If we can understand ... abuse, it could potentially suggest ways to medically counteract ...
... Digital media are changing the environment for communicating health ... New Media Landscape," University of Missouri researchers examine how ... care in the United States. Effective health communication can ... as reduce inequities in people,s access to health information ...
... Network Global Logistics (NGL), a premier provider of mission critical transportation, ... its global network of forward stocking locations (FSL,s). , ... ... a premier provider of mission critical transportation, service/spare parts logistics ...
... Jr., President & Chief Executive Officer of Concurrent Technologies Corporation ... been awarded a contract with a potential value of $90,000 ... this announcement to kick off Johnstown,s Annual Showcase for Commerce. ... Centers for Disease Control and Prevention (CDC) with Information Technology ...
... your teeth healthy. , People, who suffer from gum ... reduced their arthritic pain, number of swollen joints and the ... Researchers from the Case Western Reserve University School of ... new intervention for arthritis in the Journal of Periodontology ...
... donor factors that could affect outcomes for liver transplant ... found that donor steatosis, or fat in the liver, ... in recipients with or without HCV. However, transplants from ... affect the outcomes of HCV-positive recipients more than recipients ...
Cached Medicine News:Health News:MU researchers offer insights for advancing health communication through digital media 2Health News:NGL Expands Global Network to Service Parts Logistics Customers 2Health News:NGL Expands Global Network to Service Parts Logistics Customers 3Health News:Concurrent Technologies Corporation Awarded Contract to Support the Centers for Disease Control and Prevention with Readiness Efforts 2Health News: Treating gum disease helps rheumatoid arthritis sufferers 2Health News:Some donor factors affect outcomes for HCV-positive liver transplant recipients 2
(Date:3/31/2015)... March 31, 2015 /CNW/ - Today, the Honourable Rona Ambrose, ... animal health organizations to discuss the Government of ... (AMR). The roundtable provided an important ... share their priorities and discuss roles and responsibilities in ... their optimal use (also known as antimicrobial stewardship) was ...
(Date:3/31/2015)... , March 31, 2015 Mauna ... multidisciplinary confocal laser endomicroscopy platform, today announced the set-up ... Grenoble (university hospital center). The CHU de Grenoble is ... to propose to its gastroenterology, interventional pulmonology and ... a higher standard of care thanks to the endomicroscopy ...
(Date:3/31/2015)... Mar. 30, 2015 Research and Markets ... "Global Nuclear Imaging Market 2015-2019" report to ... Nuclear Imaging market to grow at a CAGR of ... The report, Global Nuclear Imaging market 2015-2019, has ... inputs from industry experts. The report covers the Americas, ...
Breaking Medicine Technology:Government of Canada hosts roundtable discussion to advance Canada's work on antimicrobial resistance 2Government of Canada hosts roundtable discussion to advance Canada's work on antimicrobial resistance 3Government of Canada hosts roundtable discussion to advance Canada's work on antimicrobial resistance 4Grenoble University Hospital First Hospital in France to set up a Multidisciplinary Optical Biopsy Program With the Cellvizio Endomicroscopy Platform 2Grenoble University Hospital First Hospital in France to set up a Multidisciplinary Optical Biopsy Program With the Cellvizio Endomicroscopy Platform 3Global Nuclear Imaging Market 2015-2019 with GE healthcare, Philips Healthcare & Siemens Healthcare Dominating 2
... 2011 Solos Endoscopy, Inc. (Pink Sheets: SNDY ... continued growth in 2011 through new product development, new product ... 13485 quality management system (QMS) initiative, which is a major ... sell medical devices in the European Union. Early ...
... WOONSOCKET, R.I., Jan. 6, 2011 A new CVS ... a three-year period for patients with one or more ... medications as doctors direct may save the health care ... study findings revealed robust reductions in emergency department visits ...
Cached Medicine Technology:Solos Endoscopy, Inc. Trends toward Strong Continued Growth in 2011 2CVS Caremark Study Finds Medication Adherence Leads to Lower Health Care Costs, Even After Accounting for Increased Prescription Drug Spending 2CVS Caremark Study Finds Medication Adherence Leads to Lower Health Care Costs, Even After Accounting for Increased Prescription Drug Spending 3
Microscopic needle holder, curved...
Velcro closures on each side to more evenly distribute the weight. Available in teal, royal, red, purple, or maroon nylon stain-resistant fabric or navy nylon reinforced vinyl....
Fluoro done? Get rid of your apron quickly and easily without breaking the sterile field. A shoulder drop-away can also be used with our Stretchy-back and cummmberbund aprons. Shoulder pads and hangi...
The reinforced straps are made to last and prevent the apron from falling off the shoulders. A belt loop is added to help hold the straps in place. Shoulder pads are standard and a velcro strap acros...
Medicine Products: