Navigation Links
Children's Hospital researchers identify molecular 'switch' that could save very young lives
Date:12/4/2007

A team of researchers at Childrens Hospital of Pittsburgh of UPMC have identified a molecular switch that, when blocked, may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature infants.

Results of the research were presented by principal investigator David J. Hackam, MD, PhD, a pediatric surgeon and scientist at Childrens Hospital, this weekend at the 4th Annual Meeting of the American Society for Cell Biology.

NEC is a severe inflammatory disease of the intestine that occurs in about 5 percent of premature births and can be fatal in as many as half of those cases. In extreme cases, NEC leads to perforation of the intestine, a condition that can be fatal if not treated with emergency surgery. NEC is increasing in frequency due to the increased survival of premature infants, according to Dr. Hackam.

Working in the laboratory with an animal model of NEC, Dr. Hackams team found that when molecular receptor known as Toll-like receptor-4 (TLR4) was blocked, they enabled the repair of damaged intestinal tissue that is the hallmark of NEC.

This Toll-like receptor is a defense mechanism that normally switches on the intestines immune response. But in some premature infants, stresses like oxygen deprivation and toxins caused by underdeveloped lungs stimulate the overproduction of TLR4. Like an unstoppable alarm, this signaling eventually can lead to cell death and prevent enterocytes from migrating to close wounds in the intestine, which can result in intestinal failure, Dr. Hackam said. By interfering with the production of another molecule associated with TLR4 known as focal adhesion kinase (FAK), we were able to silence the TLR4 alarm in intestinal cells.

Blocking the TLR4 signal allowed enterocytes to once again migrate and heal the damaged intestinal tissue. Dr. Hackams team is continuing to research the development of treatment strategies that would block the TLR4 switch by influencing it
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nautica Malibu Triathlon Presented by Toyota Raises $718,000 for Childrens Hospital Los Angeles Pediatric Cancer Research
2. Childrens Hospital Los Angeles Turns Off the Tap With Green Earth Waterless Carwash
3. New research explores newborn in-hospital weight loss
4. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
5. Norwalk virus: Cruise ship illness challenging and costly to hospitals, too
6. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
7. Billy Graham Home After Hospitalization:
8. Alvarado Hospital Files Countersuit Against Blue Shield
9. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
10. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
11. Annual flu shot cuts need for doctors visits, hospitalization among children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... Summer vacation is almost over and before we know ... shopping for school supplies and a new wardrobe might take ... students to also spend some time brushing up on bed ... thrive in heavily populated places,” said Randy Rupert, Bed Bug ... perfect settings for bed bugs to take up residence.” , ...
(Date:8/22/2014)... Skmen.com, an experienced supplier of fashionable clothes, has unveiled ... online store. Moreover, all these excellent items are available ... the international clients can obtain these cheap bohemian ... company’s professional online workers update its product line every ... latest information about its new arrivals and the current ...
(Date:8/22/2014)... Recently, UWDress.com, a leading online supplier of ... new range of empire bridesmaid dresses to its ... a summer promotion for these high quality items. All of ... to 75 percent off. , The company’s new items ... efficient assistance on its website. It is true that all ...
(Date:8/22/2014)... Lake Worth, FL (PRWEB) August 22, 2014 ... popularity of marijuana, resulting in a high level of drug ... of all ages fight against drug addiction and work to ... the highest levels of alcohol and drug addiction in history. ... "In 2012, an estimated 23.9 million Americans aged 12 or ...
(Date:8/22/2014)... Orleans, LA The LSU Health New Orleans ... Education Nursing Traineeship grant to increase access to ... underserved and under-represented groups, as well as veterans. ... US Department of Health and Human Services awarded ... serve as the grant,s project director., The Advanced ...
Breaking Medicine News(10 mins):Health News:Expert Advice for a Bed Bug-Free School Year 2Health News:Cheap Bohemian Dresses Unveiled by Experienced Supplier Skmen.com 2Health News:Discounted Empire Bridesmaid Dresses Online At UWDress.com 2Health News:Millennium Treatment Group Sees Increase in Marijuana Use Among Youth 2
... projected by the U.S. Census Bureau that by the year 2030, ... million in the U.S. alone, and more than one billion worldwide. ... at least one disorder of the pelvic floor in her lifetime. ... up with practitioners across the state to create the Rhode Island ...
... to loud workplace noise may affect quality of sleep in ... by Ben-Gurion University of the Negev researchers. ... the sleep quality of individuals at the same workplace, some ... Workers with hearing loss had a higher average age ...
... Jenifer Goodwin HealthDay Reporter , MONDAY, Jan. 24 ... years old become the healthiest, wealthiest and most successful adults, ... at age 3 are more likely to drop out of ... concluded. Researchers analyzed data on about 1,000 children ...
... January 2011) -- The MSD Wellcome Trust Hilleman Laboratories ... a feasibility study into how new technologies might be ... developing country needs in mind. Formulations based on ... their potential to improve product stability, ease of use, ...
... MONDAY, Jan. 24 (HealthDay News) -- For many people, ... strong as they think. In fact, spouses sometimes ... a new study suggests. "People commonly believe ... strangers. That closeness can lead people to overestimate how ...
... Genetics in Medicine , the official journal of the ... paper by Tufts University faculty calling for a moderate, ... school curricula. For 16 months, a multi-disciplinary ... education regarding personalized genomic testing at Tufts University School ...
Cached Medicine News:Health News:Women & Infants launches Rhode Island Network for Pelvic Floor Disorders 2Health News:Self-Control Could Turn Kids Into Successful Adults 2Health News:Self-Control Could Turn Kids Into Successful Adults 3Health News:MSD Wellcome Trust Hilleman Laboratories announces first project 2Health News:Close Relationships Sometimes Mask Poor Communication 2Health News:Tufts University calls for moderate approach to teaching personalized genomic testing 2
(Date:8/21/2014)... Aug. 21, 2014 /CNW/ - Eisai Limited is pleased to ... the first-of-its-kind comic book available in Canada ... designed specifically to educate children and their parents about epilepsy, ... affecting more than 300,000 Canadians. Eisai is guided by ... , in which the patient is central – there was ...
(Date:8/21/2014)... 2014  Decision Resources Group finds that, for ... Brazil and Mexico ... prescribe long-acting beta-agonist (LABA)- and long-acting muscarinic antagonist ... current severe cost/coverage constraints. Therefore, new brands of ... launch in these countries—which will considerably expand the ...
(Date:8/21/2014)... , N.Y. and HAMBURG, Germany , ... announced it is collaborating with Deutsches Elektronen-Synchrotron ( DESY ... Germany , to speed up management and storage ... Big Data and Analytics architecture based on IBM ... per second of data at peak performance and help ...
Breaking Medicine Technology:Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3
... 15 Prometheus Laboratories Inc., a specialty pharmaceutical ... launch of three new cancer diagnostic products: ProOnc ... Dx. Each of these tests is based on ... has a long and successful history of providing ...
... Oct. 15 Aethlon Medical, Inc. (OTC Bulletin Board: ... treatment of Hepatitis-C (HCV) infected patients with the Aethlon ... & Scientific Exposition of the American Society of Nephrology ... studies and Director of Nephrology at the Fortis Hospital ...
Cached Medicine Technology:Prometheus Launches ProOnc Dx Cancer Diagnostics 2Prometheus Launches ProOnc Dx Cancer Diagnostics 3Aethlon Medical Announces Presentation of Hepatitis-C (HCV) Clinical Data at 42nd Annual American Society of Nephrology (ASN) Conference 2Aethlon Medical Announces Presentation of Hepatitis-C (HCV) Clinical Data at 42nd Annual American Society of Nephrology (ASN) Conference 3
... Thermo Scientific Finnpipette Dispenser cover all volumes ... very high consistency, precision and reproducibility, due ... The Finnpipette Dispenser range is the latest ... manual liquid handling products, offering users reliability ...
... compact, mobile femtosecond surgical laser, has been ... for a wide spectrum of applications in ... demand of refractive surgeons for an "all-Laser ... efficient LASIK work-flow. The solution by Ziemer ...
... EHEC is the first one-step 20 minutes rapid ... and 2 produced by Enterohemorrhagic Escherichia coli in ... overnight enrichment of fecal specimens and detects all ... The separate result for Toxin 1 and 2 ...
Inquire...
Medicine Products: