Navigation Links
Children's Hospital physicians publish review of transplant issues in patients with biliary atresia
Date:1/8/2008

The most common indication worldwide for pediatric transplantation, biliary atresia is also the most common cause of chronic liver disease in newborns. Recently, Childrens Hospital of Pittsburgh of UPMC physicians completed a review of issues that children with biliary atresia face that lead to the need for transplantation.

Nationally about 42 percent of children undergoing their first liver transplant are diagnosed with biliary atresia. Through the review, which is published in the November issue of Liver Transplantation, doctors at Childrens propose that carefully planned medical management of children with biliary atresia is essential to minimize morbidity and mortality. Optimal outcomes for liver transplantation are reached by carefully examining indications for and alternative to transplantation and through the management of clinical problems for children with biliary atresia.

Careful assessment of the clinical status of children with biliary atresia is essential, said co-author Benjamin L. Shneider, MD, director, Pediatric Hepatology Program at Childrens. It is so important to optimize medical and surgical management and carefully determine the timing for liver transplantation, if it is needed.

At Childrens, 308 primary liver transplants were performed between 1995 and 2006. Of these, 103, or 33 percent, were performed for biliary atresia. Overall patient survival and graft survival rates at more than 10 years were 88 percent and 81 percent, respectfully, among the highest long term survival rates in the world. These patients were enrolled in the Studies on Pediatric Liver Transplantation (SPLIT) --- a multi-center, prospective study to collect scientific data on pediatric liver transplantation.

Surgical outcomes after liver transplantation for biliary atresia are outstanding in spite of complex anatomic issues and the small size of many of our patients, said co-author George Mazarigeos, MD, director of the Hillman Center for Pediatric Transplantation. By using a full complement of surgical techniques, an experienced center can minimize mortality for children awaiting transplantation. In addition, this can lead to excellent long-term outcomes.

Biliary atresia, which occurs once in every 15,000 births, is an irreversible problem that is fatal without treatment. However, surgical intervention (the Kasai hepatoportoenterostomy) may allow a child with biliary atresia to live longer and have a better quality of life. In order to have optimal results, infants should undergo surgery before 2 months of age, necessitating early referral. Symptoms of biliary atresia occur between 2 weeks to 2 months of life, and may include: jaundice that persists beyond 3 weeks of age, dark urine, light colored stools and failure to thrive.


'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Related medicine news :

1. Nautica Malibu Triathlon Presented by Toyota Raises $718,000 for Childrens Hospital Los Angeles Pediatric Cancer Research
2. Childrens Hospital Los Angeles Turns Off the Tap With Green Earth Waterless Carwash
3. New research explores newborn in-hospital weight loss
4. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
5. Norwalk virus: Cruise ship illness challenging and costly to hospitals, too
6. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
7. Billy Graham Home After Hospitalization:
8. Alvarado Hospital Files Countersuit Against Blue Shield
9. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
10. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
11. Annual flu shot cuts need for doctors visits, hospitalization among children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... 2016 , ... Boar’s Head Brand®, one of the nation’s leading providers of ... Take the stress out of your party preparation – follow these easy, yet delicious ... of the game. , “The key to hosting a successful game-day party is creating ...
(Date:2/5/2016)... Atlanta, Georgia (PRWEB) , ... February 05, 2016 , ... ... pleased to announce their 2nd Annual No Cost Dental Day to individuals in need. ... 4pm. The purpose of this No Cost Dental Day is to provide dental care ...
(Date:2/5/2016)... ... 05, 2016 , ... Colorize is a web theme package created ... next using Colorize's dynamic moving camera. Colorize is perfect for personal and web related ... environment with 1 to 5 focus points per scene, stage floor scene presets that ...
(Date:2/5/2016)... ... 2016 , ... California Mobile Kitchens , a company ... latest mobile kitchen model, featuring customizable stainless steel interiors and a new, 26-foot ... use anywhere in the U.S. Many of their units can be seen at ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... Men’s Soccer Career Development event in New York City on Thursday, January 21, ... and CEO of Mediacom, (both alumnus of the varsity Columbia soccer program) spoke ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... -- The Senior Care Pharmacy Coalition (SCPC) today commended ... Jason Chaffetz (R-UT) and Ranking Member Elijah ... "Developments in the Prescription Drug Market," to examine ... abusive pharmacy benefit manager (PBM) pricing practices. ... Elijah Cummings (D-MD) are diligent, serious lawmakers committed ...
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... filed in the United States District Court for the District ... class (the "Class") consisting of all persons or entities who ... "Company") (NASDAQ: INSY ) from March 3, 2015 through ... and certain of its officers with violations of the Securities ...
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
Breaking Medicine Technology: