Navigation Links
Children's Hospital Oakland scientists discover soy component may be key to fighting colon cancer
Date:11/24/2009

November 18, 2009 - Oakland, Calif. A study conducted by Children's Hospital & Research Center Oakland scientists identifies a new class of therapeutic agents found naturally in soy that can prevent and possibly treat colon cancer, the third most deadly form of cancer. Sphingadienes (SDs) are natural lipid molecules found in soy that research shows may be the key to fighting colon cancer.

The study, led by Julie Saba, MD, PhD, senior scientist and director of the Cancer Center at Children's Hospital Oakland Research Institute (CHORI), will be featured in the December 15, 2009 issue of Cancer Research. Soy has long been touted as protective against colon cancer, but Dr. Saba's team made the groundbreaking discovery that SDs naturally found in soy may underlie the benefits of soy products.

Dr. Saba and her team first identified SDs in the fruit fly, an organism that is sometimes used to study the genetics of human diseases. Further investigation indicated that elevated SDs actually induced the death of mutant cells in the fly, revealing SDs to be cytotoxic compounds (toxic to cells). Preventative colon cancer strategies often focus on cell deatha normal process the body uses to remove unhealthy or mutant cells, like cancer cells. Coupling this discovery with the finding that soy is a rich source of SDs, researchers made an innovative connection.

"It's very exciting," said Dr. Saba. "First, we are encouraged to find a natural molecule that could be consumed through soy products as a strategy to help prevent colon cancer. Second, this information is important because we can build on our understanding of the structure and metabolism of SDs in terms of developing new drugs to treat people who already have colon cancer. Uncovering how SDs exert their effects also helps us to find the most likely combinations of drugs that may work synergistically to eliminate cancer cells and mutant cells that could give rise to cancer."

Future research is needed to identify the best way to deliver SDs and to confirm the overall toxicity when the compounds are used for extended time periods and in combination with other agents. Dr. Saba, who has already received two grants to continue her research, also hopes to determine if SDs are effective in protection against other cancers.

Dr. Saba also acknowledges that future research is needed to determine if there are other components of soy that are beneficial in fighting colon cancer. In the meantime, Dr. Saba says, "I would be comfortable recommending soy products as a change in the diet that could protect against cancer. The more that soy is studied, the more of these protective agents are found, so it's a very healthy diet choice."


'/>"/>

Contact: Erin Goldsmith
egoldsmith@mail.cho.org
510-428-3069
Children's Hospital & Research Center at Oakland
Source:Eurekalert

Related medicine news :

1. Young Adults with Cancer Focus of Program Developed by Providence Saint Joseph Medical Center and Childrens Hospital Los Angeles
2. Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology
3. 200 Families of Children With Serious Eye Problems Benefit From Unique Gift Card Program at The Vision Center at Childrens Hospital Los Angeles
4. Childrens Bedding Naturally Enhances Emotional Well-being
5. Cydcor Builds Bears and Bonds in Special Charity Event Benefitting Childrens Hospital Los Angeles
6. National Childrens Study Begins Recruiting
7. Jessica Biel and Make The Difference Network Bring Holiday Cheer to Childrens Hospital Los Angeles
8. Siegel+Gale Designs New HOPE Portal for Childrens Hospital Los Angeles
9. Childrens Hospital Los Angeles Turns Off the Tap With Green Earth Waterless Carwash
10. Nautica Malibu Triathlon Presented by Toyota Raises $718,000 for Childrens Hospital Los Angeles Pediatric Cancer Research
11. MRSA Creeping Into Hospitals From the Outside
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... ... Series at Zuckerberg San Francisco General Hospital on April 5-7. The series is ... and create new habits. The workshops cover a broad range of topics, including ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... Service (WaaS), today announced the integration of Clarity Intelligence Platform (CIP) into Cielo®, ... to offer real-time business intelligence (BI) to their small and medium business (SMB) ...
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is killed, injured or loses ... Penn Burn Center, part of the Allegheny Health Network, has partnered with Etna ... “Space Heaters Need Space” campaign. , “Space Heaters Need Space” aims to ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman ... John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns Director, ... VA Southern Nevada Healthcare System. This will be the first Fisher House in ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally owned insurance ... drive that will raise funds earmarked to purchase computers and software for Mrs. Harrison’s ... “My school is in a low-income area and has more than 60 2nd and ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016 ... http://www.sedar.com ) und der ... abrufbar.    --> http://www.sedar.com ) ... http://www.telestatherapeutics.com abrufbar.    --> ... seinen Konzernabschluss des zweiten Quartals und ...
(Date:2/12/2016)... FRAMINGHAM, Mass. , Feb. 12, 2016   ... scheduled a conference call and webcast to discuss its ... December 31, 2015, on Thursday, February 25, 2016 at ... financial results prior to the conference call and webcast.  ... the company,s financial results, highlights from the fourth quarter ...
(Date:2/12/2016)... Inc., a medical device company that pioneered the use of the ... device indicated for fusion for certain disorders of the sacroiliac (SI) ... Contractor (MAC) covering the states of Connecticut , ... Massachusetts , Minnesota , ... Rhode Island , Vermont and ...
Breaking Medicine Technology: