Navigation Links
Children's Hospital Oakland scientists discover soy component may be key to fighting colon cancer
Date:11/24/2009

November 18, 2009 - Oakland, Calif. A study conducted by Children's Hospital & Research Center Oakland scientists identifies a new class of therapeutic agents found naturally in soy that can prevent and possibly treat colon cancer, the third most deadly form of cancer. Sphingadienes (SDs) are natural lipid molecules found in soy that research shows may be the key to fighting colon cancer.

The study, led by Julie Saba, MD, PhD, senior scientist and director of the Cancer Center at Children's Hospital Oakland Research Institute (CHORI), will be featured in the December 15, 2009 issue of Cancer Research. Soy has long been touted as protective against colon cancer, but Dr. Saba's team made the groundbreaking discovery that SDs naturally found in soy may underlie the benefits of soy products.

Dr. Saba and her team first identified SDs in the fruit fly, an organism that is sometimes used to study the genetics of human diseases. Further investigation indicated that elevated SDs actually induced the death of mutant cells in the fly, revealing SDs to be cytotoxic compounds (toxic to cells). Preventative colon cancer strategies often focus on cell deatha normal process the body uses to remove unhealthy or mutant cells, like cancer cells. Coupling this discovery with the finding that soy is a rich source of SDs, researchers made an innovative connection.

"It's very exciting," said Dr. Saba. "First, we are encouraged to find a natural molecule that could be consumed through soy products as a strategy to help prevent colon cancer. Second, this information is important because we can build on our understanding of the structure and metabolism of SDs in terms of developing new drugs to treat people who already have colon cancer. Uncovering how SDs exert their effects also helps us to find the most likely combinations of drugs that may work synergistically to eliminate cancer cells and mutant cells that could give rise to cancer."

Future research is needed to identify the best way to deliver SDs and to confirm the overall toxicity when the compounds are used for extended time periods and in combination with other agents. Dr. Saba, who has already received two grants to continue her research, also hopes to determine if SDs are effective in protection against other cancers.

Dr. Saba also acknowledges that future research is needed to determine if there are other components of soy that are beneficial in fighting colon cancer. In the meantime, Dr. Saba says, "I would be comfortable recommending soy products as a change in the diet that could protect against cancer. The more that soy is studied, the more of these protective agents are found, so it's a very healthy diet choice."


'/>"/>

Contact: Erin Goldsmith
egoldsmith@mail.cho.org
510-428-3069
Children's Hospital & Research Center at Oakland
Source:Eurekalert

Related medicine news :

1. Young Adults with Cancer Focus of Program Developed by Providence Saint Joseph Medical Center and Childrens Hospital Los Angeles
2. Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology
3. 200 Families of Children With Serious Eye Problems Benefit From Unique Gift Card Program at The Vision Center at Childrens Hospital Los Angeles
4. Childrens Bedding Naturally Enhances Emotional Well-being
5. Cydcor Builds Bears and Bonds in Special Charity Event Benefitting Childrens Hospital Los Angeles
6. National Childrens Study Begins Recruiting
7. Jessica Biel and Make The Difference Network Bring Holiday Cheer to Childrens Hospital Los Angeles
8. Siegel+Gale Designs New HOPE Portal for Childrens Hospital Los Angeles
9. Childrens Hospital Los Angeles Turns Off the Tap With Green Earth Waterless Carwash
10. Nautica Malibu Triathlon Presented by Toyota Raises $718,000 for Childrens Hospital Los Angeles Pediatric Cancer Research
11. MRSA Creeping Into Hospitals From the Outside
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... 06, 2016 , ... The Behavioral Health Center of Excellence ... organization as a top behavioral service provider in the country. The award celebrates ... satisfaction and qualifications, and consumer satisfaction. These areas are measured via a wide-ranging ...
(Date:12/6/2016)... ... December 06, 2016 , ... Experimentation involving human stem ... largely due to its potential for revolutionizing human disease treatment. There are multiple ... pluripotent stem cells (hiPSCs). , Both platforms have distinct advantages and disadvantages, ...
(Date:12/6/2016)... ... 06, 2016 , ... METTLER TOLEDO has launched its online ... white papers, guides, handbooks, case studies, magazines, webinars, videos, catalogs, brochures, datasheets, user ... documents, webinars and videos available online, visit the METTLER TOLEDO Expertise Library ...
(Date:12/6/2016)... ... ... 'Tis the season for family, festivity, food and fun! Temptation abounds, and ... eating healthy, staying active, and taking medication and doing daily foot health checks (a ... "Shopping trips, parties and family gatherings can take their toll on our feet during ...
(Date:12/6/2016)... B.C., Canada (PRWEB) , ... December 06, 2016 ... ... (STC) announce the availability of the newly updated International Audit Protocol Consortium (IAPC) ... use IAPC EHS audit protocols to understand the scope of their EHS regulatory ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... According to a new market research report "Cartilage Repair/ Cartilage ... Scaffolds, Cell-free composites), Application (Hyaline Cartilage, Fibrocartilage), by Region - Forecast ... USD 779.8 Million by 2021 from USD 414.6 Million in 2016, ... 2016 to 2021. Continue Reading ... ...
(Date:12/5/2016)... PUNE, India , December 5, 2016 /PRNewswire/ ... Market Research, titled, "Global Cancer Biomarkers Market - Global Opportunity ... biomarkers market is projected to reach $15,737 million by 2022 ... from 2016 to 2022. Omic technologies segment accounted for more ... expected to maintain its dominance during the forecast period. ...
(Date:12/5/2016)... 2016  CVS Health, the nation,s largest pharmacy innovation ... score of 100 percent on the Corporate Equality Index ... an annual national benchmarking survey and report on corporate ... the Human Rights Campaign Foundation. "Our ... colleagues, customers and suppliers bring to CVS Health," said ...
Breaking Medicine Technology: