Navigation Links
Children's HIV Drugs May Cause High Cholesterol
Date:8/5/2011

FRIDAY, Aug. 5 (HealthDay News) -- Children with HIV who receive antiretroviral treatments have persistently high cholesterol and other blood fat (lipid) levels, and would benefit from guidelines aimed at reducing their long-term heart risks, researchers say.

The findings are published in JAIDS: Journal of Acquired Immune Deficiency Syndromes.

"Formal guidelines are the first crucial step in minimizing cardiovascular disease complications and maximizing quality of life in this vulnerable population," the authors of an editorial said in a journal news release. The most effective strategy probably consists of a "lipid-friendly" drug regimen -- meaning medications that don't affect blood fats -- along with lifestyle changes, such as diet and exercise, they said.

The editorial accompanies two studies in the Aug. 15 issue that examined blood fats in children treated for HIV.

In one study, led by Denise L. Jacobson of Harvard School of Public Health, the researchers followed 240 HIV-infected children with high cholesterol for two years. During this time, the children had persistently high lipid levels. Cholesterol levels dropped to normal in only about one-third of the children.

Cholesterol levels were more likely to decline when changes were made to their antiretroviral treatment, the researchers found. In most cases, medication changes were related to the HIV, not lipid levels. Only 15 of the children were given drugs specifically to manage their cholesterol.

In a separate study, researchers at the Imperial College School of Medicine, London, compared the effect of different HIV drugs on 449 HIV-infected children's lipid levels. They found all of the drugs caused a surge in cholesterol. The class of HIV drugs known as protease inhibitors, in particular, triggered the biggest increase.

Within five years, 10 percent of children developed low-density lipoprotein ("bad") cholesterol levels above the 95th percentile. But based on those numbers, only three patients needed to take cholesterol medication.

Because HIV-infected children are likely to live well into adulthood, the researchers said treatment strategies need to be developed that will protect them against heart disease later in life.

"Clinical trials are required to develop and test intervention strategies to protect against cardiovascular disease in children born with HIV, growing into adult life," Dr. Margaret P. Rhoads of Imperial College and co-authors wrote in the news release.

More information

The U.S. Centers for Disease Control and Prevention provides statistics on HIV/AIDS among children.

-- Mary Elizabeth Dallas

SOURCE: JAIDS: Journal of Acquired Immune Deficiency Syndromes, news release, Aug. 3, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researcher at Childrens Hospital LA discovers way to overcome radiation resistance in leukemia
2. Parents Want Electronic Access to Their Childrens Docs: Survey
3. Cholesterol-lowering drugs may help prevent recurrent strokes in younger people
4. Are Newer MS Drugs Worth Their High Price Tag?
5. Cancer drugs may help treatment of schizophrenia
6. New mouse model for testing cancer drugs
7. Drugs Can Bring HIV-Infected Africans Normal Life Spans
8. UNC receives NIH grant to develop and test new drugs to block HIV infection
9. Drugs May Prevent HIV Spread Among Heterosexuals
10. Generic, Brand-Name Heart Drugs Seem to Have Same Effect on Thyroid
11. The metabolic effects of antipsychotic drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Children's HIV Drugs May Cause High Cholesterol
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical Therapy Association ... CA at the Anaheim Convention Center. Almost 10,000 physical therapists across the country are ... action, learn more about their chosen field and network with their colleagues. As ...
(Date:2/12/2016)... ... 2016 , ... Coco Libre, the maker of coconut water beverages with a ... Lounge Event. Coco Libre will offer musicians and celebrities the company’s signature Organic Coconut ... invitation-only gifting suite, held this year at the W Hollywood Hotel, has become a ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ThedaCare Center for ... General Hospital on April 5-7. The series is a multi-day, multi-workshop event designed ... workshops cover a broad range of topics, including coaching skills, the scientific method ...
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is ... winter the West Penn Burn Center, part of the Allegheny Health Network, ... to bring you the “Space Heaters Need Space” campaign. , “Space Heaters ...
(Date:2/12/2016)... ... 2016 , ... AssureVest Insurance Group, a locally owned insurance firm with offices ... raise funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and 3rd ... in a low-income area and has more than 60 2nd and 3rd graders with ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)...  SI-BONE, Inc., a medical device company that pioneered the use ... surgical (MIS) device indicated for fusion for certain disorders of the ... Medicare Administrative Contractor (MAC) covering the states of Connecticut ... , Massachusetts , Minnesota , ... , Rhode Island , Vermont ...
(Date:2/12/2016)... Texas , Feb. 12, 2016 On ... for Robotic Surgery at St. David,s North Austin Medical ... da Vinci ® Xi ® Surgical System ... 7000dV. Thiru Lakshman , M.D., colorectal ... a total proctocolectomy utilizing Integrated Table Motion technology, which ...
(Date:2/12/2016)... BUFORD, Ga. , Feb. 12 2016  OMS ... office-based dental and medical practitioners, announced today the recent ... website offers visitors a variety of features that enhance ... purchase oral surgery supplies. --> ... Supply is a fairly new company that started in ...
Breaking Medicine Technology: