Navigation Links
Children's Belly Aches Don't Disappear With Antidepressant
Date:10/1/2009

Elavil worked no better than placebo in study of kids with gastrointestinal disorders

THURSDAY, Oct. 1 (HealthDay News) -- Contradicting some previous research in adults, a new study suggests that the antidepressant amitriptyline (Elavil), is no better than a placebo at treating painful gastrointestinal disorders in children.

"The high placebo effect we identified in this study suggests that further studies of the use of certain antidepressants in children with functional bowel disorders are needed. While several trials have demonstrated a beneficial effect of antidepressants, including amitriptyline, for the treatment of irritable bowel syndrome in adults, more research is needed to determine how effective this drug is, if at all, in children," study author Dr. Miguel Saps of Children's Memorial Hospital in Chicago, said in a news release from the American Gastroenterological Association.

The drug is used to treat depression, but it is sometimes prescribed on an "off-label" basis to children who have certain painful gastrointestinal disorders. The drug is thought to reduce pain, the researchers noted.

"Off label" means that the drug is not federally approved for use to treat a condition. However, doctors can still prescribe it for that purpose.

In the study, 83 children with painful gastrointestinal disorders were randomly assigned to take the drug or a placebo. Of those who took the drug, 63 percent reported feeling better, while 5 percent felt worse. Among those taking the placebo, 57.5 reported feeling better and 2.5 percent felt worse, the study authors reported.

The study findings appear online in advance of publication in an upcoming print issue of the journal Gastroenterology.

"Many pharmaceutical products are prescribed for off-label use in children due to the lack of clinical trials testing the efficacy of the drugs in children and adolescents," Saps explained in the news release. "Therefore, the pediatric gastroenterologist frequently has to make treatment decisions without the evidence of how drugs work in children," he added.

More information

Learn more about abdominal pain in children from the American College of Gastroenterology.



-- Randy Dotinga



SOURCE: American Gastroenterological Association, news release, Oct. 1, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Young Adults with Cancer Focus of Program Developed by Providence Saint Joseph Medical Center and Childrens Hospital Los Angeles
2. Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology
3. 200 Families of Children With Serious Eye Problems Benefit From Unique Gift Card Program at The Vision Center at Childrens Hospital Los Angeles
4. Childrens Bedding Naturally Enhances Emotional Well-being
5. Cydcor Builds Bears and Bonds in Special Charity Event Benefitting Childrens Hospital Los Angeles
6. National Childrens Study Begins Recruiting
7. Jessica Biel and Make The Difference Network Bring Holiday Cheer to Childrens Hospital Los Angeles
8. Siegel+Gale Designs New HOPE Portal for Childrens Hospital Los Angeles
9. Childrens Hospital Los Angeles Turns Off the Tap With Green Earth Waterless Carwash
10. Nautica Malibu Triathlon Presented by Toyota Raises $718,000 for Childrens Hospital Los Angeles Pediatric Cancer Research
11. Even modest exercise can reduce negative effects of belly fat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... PurhealthRX ... CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will ... and providing a CBD form that can be easily incorporated into liquid products, while ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 13, 2017 , ... Many families have long-term insurance that covers care for ... a waiver for care if the client has a cognitive impairment diagnosis. , ... care, is often waived, so the benefits from their insurance start immediately,” said Mechell ...
(Date:10/13/2017)... NY (PRWEB) , ... October 13, 2017 , ... Ellevate ... people in business to advocate for action towards gender equality at their inaugural Summit ... from around the globe, and reached a social audience of over 3 million. To ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... Texas , Oct. 6, 2017   Provista, ... with more than $100 billion in purchasing power, today ... news and information. The Newsroom is the ... and industry trends, infographics, expert bios, news releases, slideshows ... having access to a wealth of resources at their ...
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, Inc. ... earnings conference call and webcast on Friday, November 3, ... (EDT) and ending at approximately 8:30 a.m. (CDT) / ... the company,s 2017 financial performance and guidance for 2018, ... initiatives to enhance operational performance, and long-range financial outlook ...
Breaking Medicine Technology: