Navigation Links
Children with juvenile arthritis have higher rates of bacterial infection

Children with juvenile idiopathic arthritis (JIA) have higher rates of hospitalized bacterial infection than children without JIA according to an observational study appearing in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR). The findings show that the risk of infection among JIA patients was significantly increased with use of high-dose glucocorticoids (steroids). Methotrexate (MTX) and tumor necrosis factor alpha (TNF) inhibitors were not found to increase infection risk in this pediatric population.

Arthritis is an inflammation of the joints that causes pain, swelling, stiffness and can lead to disability. JIA refers to chronic arthritis diseases that attack young patients and the ACR estimates close to 300,000 children in the U.S are affected. While immunosuppressant therapies such as steroids, MTX, and TNF inhibitors are used to treat JIA, it is unclear how they impact infection risk.

To compare bacterial infection incidence in children with and without JIA, a research team led by Dr. Timothy Beukelman from the University of Alabama at Birmingham used U.S. Medicaid data from 2000 to 2005. The team identified 8,479 JIA patients with 13,003 person-years of follow-up and a group of 360,489 children with attention-deficit hyperactivity disorder (ADHD) for comparison. Pharmacy claims were used to determine exposure to MTX, TNF inhibitors, and oral steroid medications. Infections were identified using hospital discharge diagnoses.

Researchers determined that 42% of JIA patients used MTX and 17% used TNF inhibitors to manage their disease. JIA patients without current exposure to MTX or TNF inhibitors had an increased rate of bacterial infection compared to patients with ADHD, even after adjusting for steroid use. "Patients with JIA who were not currently treated with MTX or TNF inhibitors had a 2-fold increase in hospitalized bacterial infection rates compared to children without arthritis," explains Dr. Beukelman, "This finding suggests the inflammatory or autoimmune process may predispose children to infection regardless of therapy."

Among children with JIA, the rate of infection associated with MTX or TNF inhibitor use was similar. After adjusting for MTX and TNF inhibitor use among children with JIA, high-dose steroid use10 mg or more of prednisone dailymore than doubled the rate of subsequent infection compared to patients not taking steroids. Dr. Beukelman concludes, "A steroid-sparing treatment strategy may reduce the risk of serious infection in children with JIA."

Contact: Dawn Peters

Related medicine news :

1. Bullied Children at Greater Risk for Self-Harm, Study Finds
2. Dietary changes help some children with ADHD
3. Leaders in childrens health to gather in Boston
4. U.S. Children Exposed to Hours of Background TV Daily
5. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
6. BASPCAN - UK-wide increase in number of children
7. Out-of-hand tree nut consumption associated with better diet quality in children and adults
8. Supporting LGB children may influence their long-term health, BU study finds
9. Children Born to Obese Moms May Face Higher Autism Risk: Study
10. In children born with severe heart defect, surgical management has little effect on neuro outcomes
11. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
Post Your Comments:
(Date:10/13/2015)... Angeles, CA (PRWEB) , ... October 13, 2015 , ... ... To incentivize would-be customers, eMarketing Concepts began a $1 promotion – effectively offering all ... a resounding success, and within weeks the company was flooded with phone calls from ...
(Date:10/13/2015)... ... 13, 2015 , ... The Bill Howe Family of Companies is an award ... and flood remediation services. Family-owned and operated for 35 years, they have maintained value, ... Diego plumber two years in a row from the Union Tribune Reader’s Poll, a ...
(Date:10/12/2015)... , ... October 13, 2015 , ... ... its biannual Heroes in Recovery Awards at Foundations Recovery Network’s Moments of Change ... presented the one-of-a-kind awards to Noah Levine and Dean Dauphinais who exemplify the ...
(Date:10/12/2015)... North Carolina (PRWEB) , ... October 12, 2015 , ... Kevin Costello, winner of the ... North Carolina , embarks today for his dream vacation to Hawaii. , “I didn’t believe ... worked out,” he says. “This contest encouraged me to get to the gym and invest ...
(Date:10/12/2015)... ... 2015 , ... The American Society of Clinical Hypnosis (ASCH) ... and clinical training in a health care discipline. , Many practitioners claim ... losing weight, managing pain, or stopping smoking, etc. Frequently, extravagant statements and guarantees ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... LONDON , Oct. 12, 2015 ... eye, it is quite challenging to deliver an ophthalmic drug ... be overcome for a successful ocular drug delivery. These include ... by the lymphatic system of conjunctiva and drug permeation issues ... of the drug, in topical eye drops, is lost due ...
(Date:10/12/2015)... Oct. 12, 2015  The Pharmacy Compounding Accreditation ... Compounding Pharmacy in Costa Mesa ... of the pharmacy,s commitment to meeting and/or exceeding ... --> --> ... --> --> Harbor ...
(Date:10/12/2015)... 2015  MiMedx Group, Inc. (NASDAQ: MDXG ), ... and patent-protected processes to develop and market advanced products ... Sports Medicine, Ophthalmic, and the Dental sectors of healthcare, ... quarter of 2015, its guidance for the fourth quarter ... $50 million Senior Secured Credit Facility. ...
Breaking Medicine Technology: