Navigation Links
Children with inflammatory bowel disease have surprisingly high folate levels, study finds
Date:1/23/2009

Children with newly diagnosed cases of inflammatory bowel disease have higher concentrations of folate in their blood than individuals without IBD, according to a new study led by researchers at the University of California, San Francisco and UC Berkeley. The findings bring into question the previously held theory that patients with IBD are prone to folate also known as folic acid deficiency.

"This is exciting work that opens the door to additional research into the role of folic acid and its genetic basis in the development of IBD, especially in young patients," said first author Melvin Heyman, MD, a professor of pediatrics, chief of pediatric gastroenterology, hepatology and nutrition, and director of the Pediatric IBD Program at UCSF Children's Hospital.

The study appears in the February 2009 issue of the "American Journal of Clinical Nutrition" and is currently available online at http://www.ajcn.org/cgi/content/full/89/2/545.

IBD is a blanket term referring to illnesses that cause chronic inflammation in the intestines, including ulcerative colitis, which manifests itself in the colon, and Crohn's disease, which can arise anywhere in the intestinal tract, according to Heyman. IBD occurs in children of all ages and can cause abdominal pain, diarrhea, fever, bleeding and nutritional deficiencies, he added.

Previous research has shown that adults with IBD tend to have lower folate levels than those without the disease, according to Nina Holland, PhD, a senior author on the paper. A folate deficiency may have multiple causes, such as poor absorption of folate across the intestinal tract, lower dietary intake of the nutrient, and medication interactions, Holland explained.

"However, pediatric IBD appears to be somewhat different from the adult form, and before this study very little was known about folate levels in newly diagnosed children with this disease," said Holland, who is also a professor of genetics and toxicology at UC Berkeley.

Folate, a form of water-soluble vitamin B, helps produce and maintain new cells, according to the National Institutes of Health. Folate occurs naturally in certain foods, including leafy green vegetables like spinach and turnip greens, citrus fruits and a variety of beans, and is also available as a dietary supplement.

"Folate has extremely important health implications and has actually been shown to prevent changes to DNA that may lead to cancer and birth defects," said Holland.

The researchers measured blood folate levels in 78 children -- 5 to 17 years old who were recruited from clinics participating in the Pediatric IBD Consortium that is comprised of six primary centers across the U.S. (in Atlanta, Boston, Chicago, Houston, Philadelphia and San Francisco). Of those children, 37 had newly diagnosed, untreated IBD, and 41 served as controls. Both the red blood cell folate concentrations and whole-blood concentrations were compared between the two groups.

The subjects' blood samples were all processed, analyzed and stored at the Children's Environmental Health Laboratory at UC Berkeley.

Results indicated that red blood cell folate concentrations were 19.4 percent lower in the controls than in the IBD patients, and whole-blood concentrations were 11.1 percent lower in the controls.

The researchers also compared the dietary intake of folate between the two groups by administering questionnaires that gauged the amount of folate each subject ingested through food and vitamin supplements. It was interesting, they noted, that dietary folate intake was 18.8 percent higher in the controls than in patients with IBD.

"We were surprised to see the IBD patients had significantly higher blood folate concentrations than the controls, even though the latter group appeared to have higher dietary folate intakes," Heyman said.

The findings may have important clinical implications for treating IBD in children. To date, many clinicians have recommended folate supplementation for all IBD patients. Yet because the study found normal folate concentrations in children with newly diagnosed cases, this recommendation might need to be reconsidered, Heyman explained.


'/>"/>

Contact: Kate Schoen
kschoen@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
2. CDC Warns of Spike in Hib-Linked Meningitis Among Children
3. Childrens Hospital Central California Selects Turner to Manage Addition and Renovation Project
4. UNC study: Access to state childrens health insurance programs vital to disabled children
5. North Carolina Dentists Team Up To Treat Needy Children
6. St. Christophers Hospital for Children Earns National Recognition for Nursing Excellence
7. Legion Attorneys Seek Copy of Health Department Study on Childrens Home
8. PlanetHospital(TM) Helps Gay Couples Discover Having Children Via Surrogacy in India
9. Pocket Reference Journals Releases Latest Edition of "All About Me" Leading Children's Immunization Journal for New Moms
10. National Childrens Study Begins Recruiting
11. Senate Finance Committee Delivers Childrens Insurance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
(Date:6/23/2016)... Calif. , June 23, 2016 ... CST on Thursday, July 7, 2016 , , , , ... ) , , , , EXPERT PANELISTS:  , , ... Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar ... The global pharmaceutical industry is witnessing an exceptional ...
Breaking Medicine Technology: