Navigation Links
Children of women who smoked during pregnancy at increased risk of becoming smokers
Date:3/21/2011

New research has revealed that prenatal exposure to nicotine increases the vulnerability to nicotine self-administration in adolescent mice. The results support the hypothesis that adolescents with prenatal nicotine exposure are more likely to start smoking earlier than their peers and that they are also more susceptible to the addictive effects of nicotine, especially as a result of stress and peer pressure. The study performed with mice is part of a project researching the behavioural and molecular mechanisms of nicotine addiction. The research project was carried out under the Academy of Finland's Research Programme on Substance Abuse and Addictions.

The key observation made by the Finnish and Russian researchers in the project was that adding nicotine to the drinking water of pregnant mice led to differences between the control and nicotine-exposed offspring in terms of nicotine self-administration. Treating the dams with nicotine during the prenatal period increased the frequency of self-administration in the offspring compared to the control group, even at lower doses.

The study also examined the receptor-level combined effects of opioids (morphine and morphine-related compounds) and nicotine. A receptor is a human protein to which endogenous and exogenous compounds bind. Once the receptors are activated, they trigger a number of intracellular signals. The compounds that bind to a receptor may also alter or turn off the receptor signalling. The present study was conducted using cell lines that express different subtypes of nicotinic receptors. Nicotine attaches to these receptors and activates them.

The results of the research project show that morphine and its related compounds, which normally attach to their own receptors, also bind to nicotinic receptors, causing altered nicotine responses. This provides a possible explanation for the common concurrent use of nicotine and other substances. The results may also pave the way for the development of new medication used to treat both smoking and drug addiction.


'/>"/>

Contact: Professor Raimo K. Tuominen
raimo.tuominen@helsinki.fi
358-919-159-640
Academy of Finland
Source:Eurekalert

Related medicine news :

1. Terminolgy matters in parents willingness to enroll their children in research
2. Government of Canada announces results in fight to save women and children with malaria
3. In pilot study, screening detects potentially serious heart conditions in healthy children
4. University of Michigan awarded $4.9 million to help reduce obesity in preschool children
5. Hopkins Childrens study finds some patients with cerebral palsy have asymmetric pelvic bones
6. Study: Negative classroom environment adversely affects childrens mental health
7. The safety of daily magnesium oxide treatment for children with chronic constipation
8. Helicobacter pylori infection linked to decreased iron levels in otherwise healthy children, according to research at UTHealth
9. Older parents are happier with more children
10. Parents Tend to Focus on Joy, Not Costs, of Raising Children
11. Vital funding for childrens brain tumor research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... Pivot ... addition of Zack Tisch as the firm’s new Consulting Services Executive. Mr. Tisch ... firm’s national accounts, from assisting clients with initial vendor selection and pre-implementation planning ...
(Date:8/22/2017)... ... August 22, 2017 , ... ... announced recently the availability of a new professional fee E/M leveling calculator tool. ... service to the healthcare industry. E/M coding is complex which supports the need ...
(Date:8/22/2017)... ... ... is new to the Texas market, but is proudly managed by widely recognized All Star ... in Grand Prairie, TX, located in the center of the DFW Metroplex, the fourth largest ... the past 40 years with 32 convenient locations in Texas, Nevada and California resulting in ...
(Date:8/22/2017)... ... , ... “Wilderness Voices”: a collection of poetry inspired by life on a ... of published author, Martha McKown, an ordained United Methodist minister with graduate degrees in ... when her older sisters studied High School literature. She loved the early English ...
(Date:8/22/2017)... ... August 22, 2017 , ... ... Awakening” is the creation of published author, Julianne Hale, a consultant for the ... policy and counter-terrorism expert focusing on the Near East region. Julianne has ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... Tenn. and BENTON, Ky. , Aug. 2, 2017   ... member to its environmental services (ES) team to proactively reduce the risk of hospital-acquired infections ... a UV disinfection robot that uses UVC light energy to kill deadly pathogens such as ... ... Tru-D in ...
(Date:7/31/2017)... July 31, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), has ... Michigan by Crain,s Detroit Business . ... public companies by three-year revenue growth. This year,s edition measures ... To view the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... an incredible triumph," said Phil Hagerman , CEO and ...
(Date:7/28/2017)... , July 28, 2017 EnvoyHealth, a Diplomat ... pilot a program for CleverCap LITE, a technology designed ... strives to deliver innovative health technology solutions and services ... CleverCap LITE offers medication ... high-tech bottle cover: ...
Breaking Medicine Technology: