Navigation Links
Children of women who smoked during pregnancy at increased risk of becoming smokers

New research has revealed that prenatal exposure to nicotine increases the vulnerability to nicotine self-administration in adolescent mice. The results support the hypothesis that adolescents with prenatal nicotine exposure are more likely to start smoking earlier than their peers and that they are also more susceptible to the addictive effects of nicotine, especially as a result of stress and peer pressure. The study performed with mice is part of a project researching the behavioural and molecular mechanisms of nicotine addiction. The research project was carried out under the Academy of Finland's Research Programme on Substance Abuse and Addictions.

The key observation made by the Finnish and Russian researchers in the project was that adding nicotine to the drinking water of pregnant mice led to differences between the control and nicotine-exposed offspring in terms of nicotine self-administration. Treating the dams with nicotine during the prenatal period increased the frequency of self-administration in the offspring compared to the control group, even at lower doses.

The study also examined the receptor-level combined effects of opioids (morphine and morphine-related compounds) and nicotine. A receptor is a human protein to which endogenous and exogenous compounds bind. Once the receptors are activated, they trigger a number of intracellular signals. The compounds that bind to a receptor may also alter or turn off the receptor signalling. The present study was conducted using cell lines that express different subtypes of nicotinic receptors. Nicotine attaches to these receptors and activates them.

The results of the research project show that morphine and its related compounds, which normally attach to their own receptors, also bind to nicotinic receptors, causing altered nicotine responses. This provides a possible explanation for the common concurrent use of nicotine and other substances. The results may also pave the way for the development of new medication used to treat both smoking and drug addiction.


Contact: Professor Raimo K. Tuominen
Academy of Finland

Related medicine news :

1. Terminolgy matters in parents willingness to enroll their children in research
2. Government of Canada announces results in fight to save women and children with malaria
3. In pilot study, screening detects potentially serious heart conditions in healthy children
4. University of Michigan awarded $4.9 million to help reduce obesity in preschool children
5. Hopkins Childrens study finds some patients with cerebral palsy have asymmetric pelvic bones
6. Study: Negative classroom environment adversely affects childrens mental health
7. The safety of daily magnesium oxide treatment for children with chronic constipation
8. Helicobacter pylori infection linked to decreased iron levels in otherwise healthy children, according to research at UTHealth
9. Older parents are happier with more children
10. Parents Tend to Focus on Joy, Not Costs, of Raising Children
11. Vital funding for childrens brain tumor research
Post Your Comments:
(Date:10/13/2015)... ... , ... Curly Hair Solutions® is thrilled to be a ... featuring the newest products and services to hit the market for women. With ... to unveil their recent partnership with Trade Secrets, a leading Canadian beauty retailer. ...
(Date:10/12/2015)... TN (PRWEB) , ... October 13, 2015 , ... ... recipients of its biannual Heroes in Recovery Awards at Foundations Recovery Network’s Moments ... Recovery Network presented the one-of-a-kind awards to Noah Levine and Dean Dauphinais who ...
(Date:10/12/2015)... ... 12, 2015 , ... According to an article from ... particularly in the area of track and field, are at a significantly higher ... peers in the same age group. Dr. Steven Meier of Meier Orthopedic Sports ...
(Date:10/12/2015)... ... October 12, 2015 , ... American Family Care (AFC), the nation’s ... by opening its 151st medical center. Located at 606A Boll Weevil Circle in Enterprise, ... continue fulfilling our mission of making quality health care accessible and economical with the ...
(Date:10/12/2015)... ROSA, CA (PRWEB) , ... October 12, 2015 , ... ... (DSM) at no charge to qualified Managed Care Organizations (MCOs) in order to ... insight and analysis into their decision making process. In addition, the DSM is also ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... COSTA MESA, Calif. , Oct. 12, 2015 ... reaffirmed the accreditation of Harbor Compounding Pharmacy in ... accreditation is awarded in recognition of the pharmacy,s ... --> ... --> ...
(Date:10/12/2015)... Calif. , Oct. 12, 2015 /PRNewswire/ ... and Chief Scientific Officer of Asterias Biotherapeutics, ... company in the emerging field of regenerative ... webcast, sponsored in part by Asterias Biotherapeutics, ... Lebkowski will discuss the progress to date ...
(Date:10/12/2015)... , Oct. 12, 2015  In a Sutter ... the Journal of Neurology, Neurosurgery, and Psychiatry, the blood ... brain atrophy and cognitive decline in patients in the ... --> --> IVIG, extracted from the ... to amyloid, an abnormal brain protein found in patients ...
Breaking Medicine Technology: