Navigation Links
Children of women who smoked during pregnancy at increased risk of becoming smokers
Date:3/21/2011

New research has revealed that prenatal exposure to nicotine increases the vulnerability to nicotine self-administration in adolescent mice. The results support the hypothesis that adolescents with prenatal nicotine exposure are more likely to start smoking earlier than their peers and that they are also more susceptible to the addictive effects of nicotine, especially as a result of stress and peer pressure. The study performed with mice is part of a project researching the behavioural and molecular mechanisms of nicotine addiction. The research project was carried out under the Academy of Finland's Research Programme on Substance Abuse and Addictions.

The key observation made by the Finnish and Russian researchers in the project was that adding nicotine to the drinking water of pregnant mice led to differences between the control and nicotine-exposed offspring in terms of nicotine self-administration. Treating the dams with nicotine during the prenatal period increased the frequency of self-administration in the offspring compared to the control group, even at lower doses.

The study also examined the receptor-level combined effects of opioids (morphine and morphine-related compounds) and nicotine. A receptor is a human protein to which endogenous and exogenous compounds bind. Once the receptors are activated, they trigger a number of intracellular signals. The compounds that bind to a receptor may also alter or turn off the receptor signalling. The present study was conducted using cell lines that express different subtypes of nicotinic receptors. Nicotine attaches to these receptors and activates them.

The results of the research project show that morphine and its related compounds, which normally attach to their own receptors, also bind to nicotinic receptors, causing altered nicotine responses. This provides a possible explanation for the common concurrent use of nicotine and other substances. The results may also pave the way for the development of new medication used to treat both smoking and drug addiction.


'/>"/>

Contact: Professor Raimo K. Tuominen
raimo.tuominen@helsinki.fi
358-919-159-640
Academy of Finland
Source:Eurekalert

Related medicine news :

1. Terminolgy matters in parents willingness to enroll their children in research
2. Government of Canada announces results in fight to save women and children with malaria
3. In pilot study, screening detects potentially serious heart conditions in healthy children
4. University of Michigan awarded $4.9 million to help reduce obesity in preschool children
5. Hopkins Childrens study finds some patients with cerebral palsy have asymmetric pelvic bones
6. Study: Negative classroom environment adversely affects childrens mental health
7. The safety of daily magnesium oxide treatment for children with chronic constipation
8. Helicobacter pylori infection linked to decreased iron levels in otherwise healthy children, according to research at UTHealth
9. Older parents are happier with more children
10. Parents Tend to Focus on Joy, Not Costs, of Raising Children
11. Vital funding for childrens brain tumor research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... June 23, 2016 , , ... July 7, 2016 , , , , LOCATION: , , ... , , , EXPERT PANELISTS:  , , , Frost & ... Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, ... The global pharmaceutical industry is witnessing an exceptional era. Several new ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology: