Navigation Links
Children of older fathers more likely to have bipolar disorder
Date:9/1/2008

Older age among fathers may be associated with an increased risk for bipolar disorder in their offspring, according to a report in the September issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Bipolar disorder is a common, severe mood disorder involving episodes of mania and depression, according to background information in the article. Other than a family history of psychotic disorders, few risk factors for the condition have been identified. Older paternal age has previously been associated with a higher risk of complex neurodevelopmental disorders, including schizophrenia and autism.

Emma M. Frans, M.Med.Sc., of the Karolinska Institutet, Stockholm, Sweden, and colleagues identified 13,428 patients in Swedish registers with a diagnosis of bipolar disorder. For each one, they randomly selected from the registers five controls who were the same sex and born the same year but did not have bipolar disorder.

When comparing the two groups, the older an individual's father, the more likely he or she was to have bipolar disorder. After adjusting for the age of the mother, participants with fathers older than 29 years had an increased risk. "After controlling for parity [number of children], maternal age, socioeconomic status and family history of psychotic disorders, the offspring of men 55 years and older were 1.37 times more likely to be diagnosed as having bipolar disorder than the offspring of men aged 20 to 24 years," the authors write.

The offspring of older mothers also had an increased risk, but it was less pronounced than the paternal effect, the authors note. For early-onset bipolar disorder (diagnosed before age 20), the effect of the father's age was much stronger and there was no association with the mother's age.

"Personality of older fathers has been suggested to explain the association between mental disorders and advancing paternal age," the authors write. "However, the mental disorders associated with increasing paternal age are under considerable genetic influence." Therefore, there may be a genetic link between advancing age of the father and bipolar and other disorders in offspring.

"As men age, successive germ cell replications occur, and de novo [new, not passed from parent to offspring] mutations accumulate monotonously as a result of DNA copy errors," the authors continue. "Women are born with their full supply of eggs that have gone through only 23 replications, a number that does not change as they age. Therefore, DNA copy errors should not increase in number with maternal age. Consistent with this notion, we found smaller effects of increased maternal age on the risk of bipolar disorder in the offspring."


'/>"/>

Contact: Emma M. Frans, M.Med.Sc.
Emma.Frans@ki.se
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Study examines relationship between low birth weight and psychiatric problems in children
2. Childrens calorie expenditure, heart rate increase during active video games
3. Stater Bros. Charities Kola Cares for Kids Radiothon Raises $161,300 for Loma Linda University Childrens Hospital
4. Florida Hospital Unveils New Details, Name for Childrens Hospital of the Future
5. Troubled children hurt peers test scores, behavior
6. Texas State Rep. Sylvester Turner Honored as Champion for Children by The AMERIGROUP Foundation
7. Davis Vision, United Way 2-1-1 and the United Auto Workers Team Up to Provide Free Vision Screenings August 25 for Detroit Children
8. WXYZ-TV/Channel 7 is On Your Side With Healthy Living For Kids; Free Immunizations for Children on Sunday, August 24 at Charles H. Wright Museum of African American History
9. Preparing To Send Your Children Off To School? Healthy Breakfast, Lunch and Snack Ideas From Cabot(R) Can Contribute to a Better, More Productive School Year
10. UNC study: chilling hardship rates among families raising disabled children
11. West Coast Bank Sponsors LifeWorks Northwest Programs for Children in Low-Income Housing Communities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... 2017 , ... Quorum Health announced that Robert A. Vento has been appointed ... Maher was promoted to COO of QHR. , A national search was ... and CEO in December 2016. , “I’m pleased to announce these ...
(Date:6/28/2017)... ... June 28, 2017 , ... Drs. Steven Crandall, Karen Johnson ... in Pittsburgh, PA, and Upper St. Clair, PA, without a referral. The doctors address ... the health of the temporomandibular joint and facial muscles that support it. , ...
(Date:6/28/2017)... ... 28, 2017 , ... Anyone with a remote control has seen the never-ending twists on the ... flipper will get rich in no time. But what about the buyers of the ... the buyer of a flipped house. An email recently sent to Gary Case said, ...
(Date:6/28/2017)... PA (PRWEB) , ... June 28, 2017 , ... ... host a one-day corporate governance program for mid-market executives as a kick-off to ... be held Sunday, Sept. 24, 2017 on the University of Pennsylvania campus, followed ...
(Date:6/28/2017)... ... June 28, 2017 , ... Canadian ... announce that a two year study conducted by the University of Saskatchewan in ... successful in remediating potash brine-impacted groundwater. As a part of the study, batch ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... , June 9, 2017 More than ... further effort to help spread lessons learned from clinical ... International Diabetes Federation (IDF) and Eli Lilly and Company ... the second phase of the Bringing Research in Diabetes ... their commitment to helping people with diabetes effectively manage ...
(Date:6/7/2017)... 2017 Endo International plc (NASDAQ: ... Hon. Joseph R. Goodwin , U.S. District Court ... Virginia , entered a case management order in ... Products Liability Litigation (the "MDL") that includes a provision ... expert disclosures on specific causation within one hundred twenty ...
(Date:6/5/2017)... Neb. , June 5, 2017 ... in the United States . ... helps a fallen person up to an almost-standing ... easily assembled and operated by one assistant and does ... It is simple enough that a child can operate ...
Breaking Medicine Technology: