Navigation Links
Children in affluent countries more likely to develop allergy-related asthma
Date:9/14/2007

Children with allergic sensitizations in economically developed countries are much more likely to develop asthma than similarly sensitized children in poorer countries, according to a team of international researchers.

The global research study is the first to link economic development to differences in rates of asthma symptoms and allergic sensitization, based on examination of a large, multi-center cross-sectional study of 8- to 12-year-old children who participated in Phase Two of the International Study of Asthma and Allergy in Childhood (ISAAC).

The findings were published in the second issue for September of the American Thoracic Societys American Journal of Respiratory and Critical Care Medicine.

Atopic sensitization has long been known to be related to childhood asthma, wrote Gudrun Weinmayr, M.D., M.P.H., of the Institute of Epidemiology of Ulm University in Germany, and lead investigator of the study. Dr. Weinmayr noted that the strongest relationships have been found in studies in affluent western countries. Thus, it may be that the link between asthma and atopic sensitization differs between countries.

Dr. Weinmayr and colleagues evaluated parents answers about their childrens respiratory symptoms from over 54,000 standardized questionnaires; assessed the results of more than 31,000 skin-prick tests; and analyzed the serum levels of allergen-specific IgE in nearly 9,000 children from 22 countries, from rural African to urban Europe.

They then determined the degree to which allergic sensitizations and asthma symptoms varied with the gross national income per capita (GNI) of the country from which they were collected.

We observed large variations in the prevalence of asthma symptoms and of atopic sensitization among populations, wrote Dr. Gundmayr. The association between current wheeze, an indicator of asthma, and skin prick sensitivity, an indicator of allergic reaction, was strong in virtually all affluent countries, but much weaker in less affluent settings.

Altogether, children living in affluent countries with allergic sensitizations were 4 times as likely to have asthma than their non-sensitized counterparts; in non-affluent countries, children with allergic responses were only 2.2 times as likely to have asthma.

This means that local environmental factors may affect asthma and allergy in different ways, said Renato T. Stein, M.D., Ph.D., of the Pontificia Universidade Catolica do Rio Grande do Sul, in Brazil, another researcher involved in the study.

Another way to interpret these findings is that asthma in [more affluent] cities is predominantly atopic asthma, while in socially less developed areas asthma may be more of the non-atopic phenotype, said Dr. Stein.

The researchers speculated that a possible explanation could be that some factors that protect children with allergic sensitization from developing asthma are less present in affluent settings, or that acquired commensal bacteria (gut flora), which may also differ with GNI, play a role in development of tolerance and immune function.

A wide range of different factors, including nutrition, microbial and allergen exposure, housing conditions, and exposure to pollutants, and so forth may have played a role, they wrote, remarking that a center level correlation with GNI does not imply a similar relation at the individual level with personal wealth.

The research will continue with further investigations in other risk factors in asthma development, including diet, the presence of rhinitis, and eczema. Data to study the impact of genetics in asthma and allergies has been collected and is a central part in the next steps of this study, said Dr. Stein.


'/>"/>

Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
2. Inhaled Steroids Safe & Effective for Children with Asthma
3. General Anesthesia Safe For Children On Ketogenic Diet Suffering From Epilepsy
4. Starvation in pregnant women can cause heart disease to their children
5. Fireworks can spell death for asthmatic children
6. Cut down TV and video games and you have less aggressive children.
7. Children suffer the most when parents divorce
8. Half of worlds children are passive smokers - damning disclosure from WHO
9. Antibiotic induces liver damage in children with E.COLI infections.
10. Analgesic abuse - cause for chronic headache in children
11. Cats to protect children from asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... New studies ... of injured workers across 15 states. The outcomes examined in these studies include ... medical care, and satisfaction with medical care. , “The goal of the studies ...
(Date:5/25/2016)... ... 25, 2016 , ... Today Omega Institute, a leading destination for yoga education ... training opportunities in the growing field of yoga therapy . Yoga therapy ... with specific health issues—including injuries, illnesses, and temporary or chronic health conditions. , “Yoga ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... planning services and products in the developing world, is pleased to release their ... prevent over 5 million unwanted pregnancies, almost 14,000 maternal deaths and 3.8 million ...
(Date:5/25/2016)... Coral Gables, FL (PRWEB) , ... May 25, ... ... in its Cross Benefit Clearinghouse supporting the real time adjudication of medical service ... Urgent Care providers using their current medical claims management software. The TransactRx Cross ...
(Date:5/25/2016)... ... May 25, 2016 , ... The University of San Francisco ... Professions. She will lead a team of more than 100 full-time faculty and staff, ... role as dean in late August. , Baker comes to USF from the University ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 Inivata, a global ... circulating tumour DNA (ctDNA) analysis to improve personalised ... Professor Clive Morris as Chief Medical ... clinical development programme, scientific collaborations, and through to ... improvements in clinical outcomes for patients. ...
(Date:5/24/2016)... , May 24, 2016 ... médica para ayudar a los médicos a compartir sus ... pacientes a escala mundial. Profesionales médicos de Europa, África, ... se han apuntado a la aplicación, que combina la ... un entorno totalmente seguro. Educación   ...
(Date:5/24/2016)... 24, 2016  Diana Russell suffers from a form ... the inside out.  This disease has put her in ... children and grandchildren to leave her home.  Because of ... cannot haul the wheelchair.  So if there is a ... Diana is left to wait for the bus. ...
Breaking Medicine Technology: