Navigation Links
Children failing asthma therapy may have severe asthma with fungal sensitization
Date:5/22/2012

ATS 2012, SAN FRANCISCO New research presented at the ATS 2012 International Conference in San Francisco suggests that a significant proportion of children with asthma failing Step 4 or greater therapy may have severe asthma with fungal sensitization (SAFS).

"SAFS is a newly described sub-phenotype of asthma, and its prevalence and clinical characteristics in children are unknown," said Alfin Vicencio, MD, chief of pediatric pulmonology and cystic fibrosis at the Cohen Children's Medical Center in Great Neck, NY, and David Goldman, associate professor of pediatric infectious diseases at the Children's Hospital at Montefiore, Bronx, NY.

"Accordingly, we prospectively analyzed serum immunoglobulin E (IgE) levels and fungal sensitization patterns in 41 children failing combination asthma therapy. Of these 41 patients, 17 (41.5%) were diagnosed with SAFS."

Compared with those without SAFS, children with SAFS were older, had higher serum IgE levels, and performed worse on pulmonary function tests. These differences remained significant when children with SAFS were compared to a subset of children without SAFS who were sensitized to non-fungal environmental allergens.

The most commonly implicated organisms were Aspergillus spp (81.2%) and Alternaria spp (68.8%), but numerous other species were represented. More than 65% of children with SAFS exhibited sensitization to more than one fungal species. Airway remodeling and persistent eosinophilia may also be associated with SAFS, although the researchers note that additional studies are required to more clearly characterize these features of the disease.

"Our results suggest that SAFS may account for a significant proportion of severe asthma in our pediatric population," said Dr. Vicencio. "At this point, however, there are still many unanswered questions, including the role of anti-fungal therapy."

"We are actively pursuing new methods to identify fungal organisms
'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Baseline characteristics of children with mild persistent asthma predict response to ICS
2. Study evaluates use of inhaled saline for young children with cystic fibrosis
3. Study says children exposed to tobacco smoke face long-term respiratory problems
4. Prenatal exposure to pollution especially dangerous for children with asthma
5. Oxytocin improves brain function in children with autism
6. Introducing Screenplay: An interactive childrens waiting room experience
7. Developmental Woes Common in Siblings of Children With Autism
8. Ben-Gurion U. and Cincinnati Childrens Hospital to develop pediatric-specific medical technologies
9. Study finds number of battery-related emergency department visits by children more than doubles
10. Disparities in treatment of children in the emergency department based on their insurance status
11. A place to play: Researcher designs schoolyard for children with autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... (PRWEB) March 27, 2015 Airy Jeanine ... released the official music video for her debut song ... , Combining live-action and abstract styling effects, the thematic ... viewed on YouTube, Vimeo, and assorted outlets. It will ... development of an expanding full-scale marketing strategy. The video ...
(Date:3/27/2015)... Smile Brands Inc. ( http://www.smilebrands.com ), ... services to dental groups in the United States, is ... Dental office in Hendersonville, TN. , Located ... new Castle Dental office provides families with a convenient, ... comprehensive, quality dental care. Hendersonville marks the eleventh Castle ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 “ VXi ... of its monthly Tech Report, which features the latest ... a technology expert and special reporter for NewsWatch, conducted ... an advanced noise-cancelling headset, eliminating 90% of ambient noise. ... while texts and emails are important to any professional, ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 The Florida ... Accelerate Brain Cancer Cure (ABC2), awarded $350,000 to support ... of Florida, The Scripps Research Institute and H. Lee ... support studies with a clear development path and potential ... in the near future. , The awards fund ...
(Date:3/27/2015)... 27, 2015 The Thomas ... philanthropic, grant-making foundation committed to raising its voice ... is delivered. , The Scattergood Foundation and The ... Health Policy and Practice through the Annual Scattergood ... Program App is designed to guide the IBS ...
Breaking Medicine News(10 mins):Health News:Airy Jeanine Releases ‘’Mama’s Girl” Official Music Video 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 3Health News:A Device to Tune out Background Noise was Recently Featured on NewsWatch Television 2Health News:The Florida Center for Brain Tumor Research and Accelerate Brain Cancer Cure Award $350,000 to Florida-Based Researchers 2Health News:The Florida Center for Brain Tumor Research and Accelerate Brain Cancer Cure Award $350,000 to Florida-Based Researchers 3Health News:SoundsLikeIBS Nominated For 3rd Annual Scattergood Innovation Award 2
... Mozes HealthDay Reporter , MONDAY, Nov. 1 (HealthDay News) ... first time will have vaginal intercourse within six months, a new ... in ninth grade will have vaginal intercourse before the end of ... "Oral sex among adolescents happens," said study lead author Anna V. ...
... HealthDay Reporter , MONDAY, Nov. 1 (HealthDay News) -- Pain ... life, with reports of pain increasing during the final few months, ... people reported being "troubled" by moderate or severe pain two years ... that number had jumped to nearly half. "This study ...
... , MONDAY, Nov. 1 (HealthDay News) -- Military ... suicide, says a new study. The greatest risk ... substance abuse disorders, according to the researchers at the ... the University of Michigan. Overall, bipolar disorder ...
... , MONDAY, Nov. 1 (HealthDay News) -- The success ... fat (MUFA), which are commonly found in nuts, seeds, avocados, ... oil, new research suggests. In the study, researchers randomly ... moderate elevated cholesterol levels to either a high-MUFA diet or ...
... News) -- Women who eat peanuts during pregnancy may be ... new study suggests. U.S. researchers looked at 503 infants, ... milk allergies, or with the skin disorder eczema and positive ... with increased risk of peanut allergy, but none of the ...
... MONDAY, Nov. 1 (HealthDay News) -- Stroke patients are more ... the weekend instead of a weekday, regardless of the severity ... analyzed data from almost 21,000 stroke patients admitted to 11 ... their first stroke were included in the study. Seven ...
Cached Medicine News:Health News:For Many Teens, Oral Sex Leads to Riskier Activity 2Health News:For Many Teens, Oral Sex Leads to Riskier Activity 3Health News:Almost Half of Elderly Report Pain in Life's Final Months 2Health News:Almost Half of Elderly Report Pain in Life's Final Months 3Health News:Bipolar Disorder Tied to High Suicide Risk in Veterans 2Health News:Adding Monounsaturated Fats to Diet May Boost Heart Health 2Health News:Eating Peanuts While Pregnant May Raise Child's Allergy Risks 2Health News:Weekend Admissions Worse for Stroke Victims: Study 2
(Date:3/27/2015)... VICTORIA, Texas , March 27, 2015  Victoria Vein ... removal services with the Astanza Duality laser in ... of vein disease as well as advanced laser treatments for ... are entering the tattoo industry to provide more services for ... Surgery has helped many Victoria residents ...
(Date:3/27/2015)... VEGAS , March 27, 2015 Zimmer Holdings, ... efficient external fixation system for trauma patients. ... XtraFix ® External Fixation System from Zimmer ... technology and materials.   The XtraFix System ... clamps from the external fixation process, resulting in saved time, ...
(Date:3/27/2015)... DALLAS , March 27, 2015 ... Market by Product (Diagnostic Catheter (Conventional, Advanced, Ultrasound), Ablation ... ICE, X-ray)) & Indication (AF, VT, WPW) - Global ... Market is expected to reach around ~$4.73 Billion by ... forecast period 2014 to 2019. Browse ...
Breaking Medicine Technology:Victoria Vein And Surgery Clinic Uses Advanced Astanza Duality Tattoo Removal Technology 2Zimmer Debuts New Modular External Fixation System 2Zimmer Debuts New Modular External Fixation System 3Electrophysiology (EP) Market Worth $4.73 Billion by 2019 2Electrophysiology (EP) Market Worth $4.73 Billion by 2019 3Electrophysiology (EP) Market Worth $4.73 Billion by 2019 4
... Perceptive Informatics, the industry,s leading eClinical solutions ... (Nasdaq: PRXL ), today announced the ... webinar entitled "Optimizing Adaptive Trial Designs: Using ... conducted by Perceptive Informatics with partner Cytel Inc., ...
... C. Larry Pope, President and Chief Executive Officer of ... the following update to all employees on the progress ... operation in Veracruz:To Our Employees:The media continues to cover ... and while we would like to accommodate them and ...
Cached Medicine Technology:Perceptive Informatics Survey Results Reveal Top Barriers to Implementing Adaptive Trial Designs 2Perceptive Informatics Survey Results Reveal Top Barriers to Implementing Adaptive Trial Designs 3Perceptive Informatics Survey Results Reveal Top Barriers to Implementing Adaptive Trial Designs 4Perceptive Informatics Survey Results Reveal Top Barriers to Implementing Adaptive Trial Designs 5Smithfield Sends Update to Employees on Testing Process at Veracruz Joint Venture 2
... were developed in surgeon's desire to have ... an instrument with the strength to maneuver ... the bending or breaking. Arthrotek Hand Instruments ... to the surgeon's hand. This new generation ...
... developed in surgeon's desire to have the ... instrument with the strength to maneuver into ... bending or breaking. Arthrotek Hand Instruments are ... the surgeon's hand. This new generation of ...
... were developed in surgeon's desire to have ... an instrument with the strength to maneuver ... the bending or breaking. Arthrotek Hand Instruments ... to the surgeon's hand. This new generation ...
... Hand Instruments were developed in surgeon's desire ... still having an instrument with the strength ... fear of the bending or breaking. Arthrotek ... to conform to the surgeon's hand. This ...
Medicine Products: