Navigation Links
Children failing asthma therapy may have severe asthma with fungal sensitization
Date:5/22/2012

ATS 2012, SAN FRANCISCO New research presented at the ATS 2012 International Conference in San Francisco suggests that a significant proportion of children with asthma failing Step 4 or greater therapy may have severe asthma with fungal sensitization (SAFS).

"SAFS is a newly described sub-phenotype of asthma, and its prevalence and clinical characteristics in children are unknown," said Alfin Vicencio, MD, chief of pediatric pulmonology and cystic fibrosis at the Cohen Children's Medical Center in Great Neck, NY, and David Goldman, associate professor of pediatric infectious diseases at the Children's Hospital at Montefiore, Bronx, NY.

"Accordingly, we prospectively analyzed serum immunoglobulin E (IgE) levels and fungal sensitization patterns in 41 children failing combination asthma therapy. Of these 41 patients, 17 (41.5%) were diagnosed with SAFS."

Compared with those without SAFS, children with SAFS were older, had higher serum IgE levels, and performed worse on pulmonary function tests. These differences remained significant when children with SAFS were compared to a subset of children without SAFS who were sensitized to non-fungal environmental allergens.

The most commonly implicated organisms were Aspergillus spp (81.2%) and Alternaria spp (68.8%), but numerous other species were represented. More than 65% of children with SAFS exhibited sensitization to more than one fungal species. Airway remodeling and persistent eosinophilia may also be associated with SAFS, although the researchers note that additional studies are required to more clearly characterize these features of the disease.

"Our results suggest that SAFS may account for a significant proportion of severe asthma in our pediatric population," said Dr. Vicencio. "At this point, however, there are still many unanswered questions, including the role of anti-fungal therapy."

"We are actively pursuing new methods to identify fungal organisms in the lower airway, which would enable us to better define treatment protocols," Dr. Vicencio concluded. "In addition, we are hoping to identify genetic risk factors for disease, which could potentially lead to targeted preventive strategies early in life."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Baseline characteristics of children with mild persistent asthma predict response to ICS
2. Study evaluates use of inhaled saline for young children with cystic fibrosis
3. Study says children exposed to tobacco smoke face long-term respiratory problems
4. Prenatal exposure to pollution especially dangerous for children with asthma
5. Oxytocin improves brain function in children with autism
6. Introducing Screenplay: An interactive childrens waiting room experience
7. Developmental Woes Common in Siblings of Children With Autism
8. Ben-Gurion U. and Cincinnati Childrens Hospital to develop pediatric-specific medical technologies
9. Study finds number of battery-related emergency department visits by children more than doubles
10. Disparities in treatment of children in the emergency department based on their insurance status
11. A place to play: Researcher designs schoolyard for children with autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... Today, FloSports , a ... announced a new agreement as part of a long-term extension of their media partnership. ... the airing of some of the sport’s premier events exclusively on FloWrestling.com as well ...
(Date:1/16/2017)... ... January 16, 2017 , ... California Southern University has named Dr. ... CalSouthern’s Board of Trustees and as a core faculty member, teaching master’s and doctoral ... professor of psychology at Pepperdine University, where he earned his Doctor of Psychology degree ...
(Date:1/16/2017)... ... January 16, 2017 , ... Anybody who may be looking ... a new video released by Serenity Recovery, a holistic treatment center for addiction located ... channel, features footage and testimonials from patients and staff that visited the 2016 Recovery ...
(Date:1/16/2017)... ... 2017 , ... Specialty Technical Publishers (STP) and Specialty Technical ... (IAPC) EHS audit protocol for Singapore . Leading companies around the world ... obligations and rapidly collect, share, archive, and export audit findings in a cost ...
(Date:1/16/2017)... Hills, CA (PRWEB) , ... January 16, 2017 ... ... a manuscript in the Aesthetic Surgery Journal , the official journal of ... he conducted on lower eyelid retraction surgery. The procedure is designed to correct ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... OilPrice.com Market Commentary:  A little-known biotech company ... the planned upcoming release of a breakthrough technology that ... test that is affordable and accessible to the average ... today include:  Amgen Inc. (NASDAQ: AMGN ), ... Inc. (NASDAQ: CGIX ), Abbott Laboratories (NYSE: ...
(Date:1/17/2017)... Pa. , Jan. 17, 2017  Maureen ... Inc.(AMI) announces the addition of 6 senior sales ... the TubeClear® System.  These sales leaders were formerly ... acquired medical device company. Repeatedly recognized for their ... exceeding customer expectations and establishing relationships with key ...
(Date:1/17/2017)... Jan. 17, 2017  Tetra Discovery Partners today ... as Vice President, Clinical Operations. He joins ... Executive Director, Clinical Project Management. "Richard joins ... experience in global clinical research planning and execution, ... clinical operation build-outs and development partnerships," said ...
Breaking Medicine Technology: