Navigation Links
Children failing asthma therapy may have severe asthma with fungal sensitization
Date:5/22/2012

ATS 2012, SAN FRANCISCO New research presented at the ATS 2012 International Conference in San Francisco suggests that a significant proportion of children with asthma failing Step 4 or greater therapy may have severe asthma with fungal sensitization (SAFS).

"SAFS is a newly described sub-phenotype of asthma, and its prevalence and clinical characteristics in children are unknown," said Alfin Vicencio, MD, chief of pediatric pulmonology and cystic fibrosis at the Cohen Children's Medical Center in Great Neck, NY, and David Goldman, associate professor of pediatric infectious diseases at the Children's Hospital at Montefiore, Bronx, NY.

"Accordingly, we prospectively analyzed serum immunoglobulin E (IgE) levels and fungal sensitization patterns in 41 children failing combination asthma therapy. Of these 41 patients, 17 (41.5%) were diagnosed with SAFS."

Compared with those without SAFS, children with SAFS were older, had higher serum IgE levels, and performed worse on pulmonary function tests. These differences remained significant when children with SAFS were compared to a subset of children without SAFS who were sensitized to non-fungal environmental allergens.

The most commonly implicated organisms were Aspergillus spp (81.2%) and Alternaria spp (68.8%), but numerous other species were represented. More than 65% of children with SAFS exhibited sensitization to more than one fungal species. Airway remodeling and persistent eosinophilia may also be associated with SAFS, although the researchers note that additional studies are required to more clearly characterize these features of the disease.

"Our results suggest that SAFS may account for a significant proportion of severe asthma in our pediatric population," said Dr. Vicencio. "At this point, however, there are still many unanswered questions, including the role of anti-fungal therapy."

"We are actively pursuing new methods to identify fungal organisms in the lower airway, which would enable us to better define treatment protocols," Dr. Vicencio concluded. "In addition, we are hoping to identify genetic risk factors for disease, which could potentially lead to targeted preventive strategies early in life."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Baseline characteristics of children with mild persistent asthma predict response to ICS
2. Study evaluates use of inhaled saline for young children with cystic fibrosis
3. Study says children exposed to tobacco smoke face long-term respiratory problems
4. Prenatal exposure to pollution especially dangerous for children with asthma
5. Oxytocin improves brain function in children with autism
6. Introducing Screenplay: An interactive childrens waiting room experience
7. Developmental Woes Common in Siblings of Children With Autism
8. Ben-Gurion U. and Cincinnati Childrens Hospital to develop pediatric-specific medical technologies
9. Study finds number of battery-related emergency department visits by children more than doubles
10. Disparities in treatment of children in the emergency department based on their insurance status
11. A place to play: Researcher designs schoolyard for children with autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... ... from offices headquartered in Jefferson County, is announcing the launch of a charity ... , The number of homeless women and children in Birmingham has grown steadily ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a ... clients in and around the Hancock County area, is announcing the launch of a ... Pantry. , The Hancock County Food Pantry has worked for more than 30 years ...
(Date:12/7/2016)... ... 2016 , ... DrugDev again demonstrated its dedication to reducing the ... early adopters completing EU-U.S. Privacy Shield Certification from the U.S. Department of Commerce. ... of the Atlantic with a mechanism to comply with EU data protection requirements when ...
(Date:12/7/2016)... ... 07, 2016 , ... Kenall Manufacturing, a leader in sealed healthcare lighting for ... is a multi-function, sealed, LED luminaire that meets the needs of everyone in the ... needed. , A 2’ x 4’ model features four modes: reading, ambient, ...
(Date:12/7/2016)... ... December 07, 2016 , ... Wavelink, an industry ... Control through a new partnership with Splashtop Inc. This remote control for Android ... to help businesses maximize their uptime and productivity. , Wavelink offers powerful enterprise ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016  Hanson Research, an innovative leader in ... diffusion testing instruments for the pharmaceutical industry, announced ... Inc. ("Teledyne"). The move is designed to deepen ... instruments, as well as expand resources for further ... and services. Logo - http://photos.prnewswire.com/prnh/20161208/446988LOGO ...
(Date:12/8/2016)... , Dec. 8, 2016  Haemonetics Corporation (NYSE: ... (Donor Management System), an innovative software suite designed to help ... The launch of NextGen DMS 4 improves core features ... the cost per liter of plasma collected, enhancing quality and ... center operations. ...
(Date:12/8/2016)...   Mederi Therapeutics Inc . has announced regulatory approval by CFDA and product ... chronic gastroesophageal reflux disease (GERD). Continue Reading ... ... Congress of Digestive Endoscopy, by Professor Jun Liu, Director of Endoscopy at Wuhan Union ... "We are very pleased that Mederi products are ...
Breaking Medicine Technology: