Navigation Links
Children exposed to 2 phthalates have elevated risk of asthma-related airway inflammation
Date:9/5/2012

Children exposed to diethyl phthalate (DEP) and butylbenzyl phthalate (BBzP)phthalate chemicals commonly found in personal care and plastic productshave elevated risk of asthma-related airway inflammation, according to researchers at Columbia Center for Children's Environmental Health (CCCEH) at the Mailman School of Public Health.

Of the 244 children aged 5 to 9 in the study, all had detectable levels of phthalates in their urine although these varied over a wide range. Higher levels of both phthalates were associated with higher levels of nitric oxide in exhaled breath, a biological marker of airway inflammation. The association between BBzP exposure and airway inflammation was especially strong among children who had recently reported wheeze, a common symptom of asthma. Results were recently published online in the American Journal of Respiratory and Critical Care Medicine.

"While many factors contribute to childhood asthma, our study shows that exposure to phthalates may play a significant role," says Allan Just, PhD, first author on the new CCCEH study and current postdoctoral researcher at the Harvard School of Public Health.

Dr. Just and co-investigators looked at children enrolled in the CCCEH Mothers and Newborns study. All live in Northern Manhattan and the South Bronx where asthma prevalence is high. Exposure to phthalates was measured through a urine test, and the level of nitric oxide in the child's exhaled breath was quantified as a marker of airway inflammation.

The study is the first to use exhaled nitric oxide in a study of phthalate exposure in children. By using the biomarker in exhaled breath, the researchers overcame a significant hurdle. "Many asthma patients only have asthma exacerbations a few times a year, making it difficult to discern short-term associations between environmental exposures and the disease," explains Matthew Perzanowski, PhD, senior author and Associate Professor of Environmental Health Sciences at the Mailman School. "To solve this problem, we used nitric oxide, which has been shown to be a reliable marker of airway inflammation in response to known asthma triggers like vehicle emissions."

Phthalates are used widely in consumer products, including plastics, vinyl flooring, and personal care products, making exposure ubiquitous in the United States and other developed nations. Phthalates enter the body through ingestion, inhalation, and absorption through the skin. However, past research has suggested inhalation to be a particularly important route of exposure to the two phthalates associated with airway inflammation in this study. Several phthalates are known to disrupt the endocrine system and early-life exposure has been linked not only to asthma but also to adverse neurobehavioral and reproductive effects. A recent study by Dr. Just and other CCCEH investigators found that prenatal exposure to BBzP was linked with increased risk of childhood eczema.


'/>"/>
Contact: Timothy S. Paul
tp2111@columbia.edu
212-305-2676
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related medicine news :

1. Can gene therapy cure fatal diseases in children?
2. Children taking steroids for asthma are slightly shorter than peers
3. Triple-threat approach reduces life-threatening central line infections in children with cancer
4. Study explores why children with asthma are more likely to be bullied
5. Intervention helps children with sickle cell disease complete MRI tests without sedation
6. Diagnosis often missed for Hispanic children with developmental delay, autism
7. Secondhand Smoke May Impair Childrens Cough Reflex
8. Smoking during pregnancy increases the risk of wheeze and asthma in preschool children
9. Non-invasive treatment for children with obstructive sleep apnea suggested by Ben-Gurion University study
10. New Brain Measurements Can Pinpoint Childrens Age
11. Childrens self-control is associated with their body mass index as adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... ... personal financial planning to families and business owners in North Central West Virginia, ... help provide services to differently abled residents in the region. , The Stepping ...
(Date:6/22/2017)... ... 2017 , ... Plastic Surgery Associates is proud to report that founding surgeon, ... research and information firm, Castle Connolly, releases their list of the most notable and ... 3rd time that Dr. Canales has been recognized by Castle Connolly. , ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... grant from the American Heart Association (AHA) to launch a Rheumatic Heart Disease ... the prevention and diagnosis of rheumatic heart disease (RHD) in high-risk, financially disadvantaged ...
(Date:6/22/2017)... ... June 22, 2017 , ... Vighter, a premier provider ... certification for ANSI/ASIS PSC.1-2012. The company’s work in countries throughout Southwest Asia, South ... law has been degraded. The PSC.1 standard was created to protect fundamental freedoms ...
(Date:6/20/2017)... ... June 20, 2017 , ... TwelveStone Health Partners, a premier ... private equity firm, has invested $3.35 million in the company. , “We ... Capital offers the smart money, speed to market and accountability we had been ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... 2017   Responding to Heath Ledger,s father,s ... of singer Chris Cornell in May, the mental ... a free online psychiatric drug side effects ... about psychotropic drug risks. The father of ... an accidental overdose, has called for tighter rules on prescription ...
(Date:6/7/2017)... June 7, 2017  Novavax, Inc., (Nasdaq: NVAX ... Phase 2 trials of its RSV F protein recombinant nanoparticle ... age have been published in the journal Vaccine ... shared in prior scientific conferences). The Company previously announced ... Novavax is developing the RSV F Vaccine with the goal ...
(Date:6/5/2017)... June 5, 2017 Kohll,s Pharmacy & Homecare is the ... the United States . The Raizer is a simple ... person up to an almost-standing position within a ... by one assistant and does not require any ... that a child can operate it, and lightweight ...
Breaking Medicine Technology: