Navigation Links
Children With HIV at Higher Risk of Drug Resistance
Date:4/19/2011

TUESDAY, April 19 (HealthDay News) -- About 1 in 8 children infected with HIV experiences triple-class virological failure -- meaning the virus becomes resistant to multiple drugs -- within five years of starting antiretroviral treatment, a European study shows.

That drug failure rate is higher than in adults and highlights the challenge of maintaining viral load suppression in young patients who begin antiretroviral therapy so early in life, the researchers said.

Virological failure occurs when drugs can no longer reduce the amount of HIV in a patient's blood, according to the U.S. National Institutes of Health.

The study included more than 1,000 HIV-positive children in several European countries. The children, who were infected with HIV via their mother before or at birth, were under 16 years of age and began treatment with three or more drugs between 1998 and 2008.

Along with an overall 12 percent rate of triple-class virological failure, the researchers also found that children who began antiretroviral treatment at an older age were more likely to experience failure.

One expert said that the higher rate of virological failure may be tied to lower rates of drug adherence by kids.

"HIV is a dynamic infection in which billions of virus particles are produced each day in the bodies of HIV infected persons," explained Dr. Bruce Hirsch, attending physician in Infectious Disease at North Shore University Hospital in Manhasset, N.Y. "Though each particular virus dies off in less than a day, the high rate of production and the high mutation rate requires that three active anti-viral medicines be present in the blood stream continuously for years."

"Growing up is hard to do," Hirsch added, and "taking unpalatable medications every day is hard on young kids."

But there are potential solutions.

"Easier to take combinations, better tasting syrup versions would help children cope with this infection," Hirsch said.

The study's authors agreed. "There is continued need for strategies to promote optimum drug adherence in children, caregivers and young people to minimize the likelihood of triple-class virological failure, and for development of suitable new drugs and formulations to optimize the treatment of children with treatment failure," wrote Ali Judd and colleagues at the Medical Research Council Clinical Trials Unit in London.

The study appears online April 19 in The Lancet.

More information

The New Mexico AIDS Education and Training Center has more about HIV and children.

-- Robert Preidt

SOURCES: Bruce Hirsch, M.D., attending physician, infectious disease, North Shore University Hospital, Manhasset, N.Y.; The Lancet, news release, April 19, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hope for children with rare genetic defect
2. Childrens doctors team up across state lines to fight disease
3. Study: Parents likely to embrace predictive genetic testing for their children if offered
4. Teachers-based intervention provides stress resistance in war-exposed children
5. Nationwide Childrens Hospital accepted to Neonatal Research Network
6. Minimally invasive thyroid surgery effective in children
7. Children victims of most eye injuries from aerosols
8. NCI awards $1.7 million to cancer specialist at Childrens Hospital Los Angeles
9. UT Southwestern pediatricians launch landmark childrens health study
10. How do life-threatening medical conditions in children impact quality of life?
11. Prenatal exposure to certain pollutants linked to behavioral problems in young children
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Children With HIV at Higher Risk of Drug Resistance
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family ... next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. ... 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the ...
(Date:10/13/2017)... ... , ... Lori R. Somekh, founder of the Law Office of Somekh ... law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up ... network with elder law attorneys nationwide,” said Somekh. , ElderCounsel was ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are ... cessation in breathing. Oral appliances can offer significant relief to about 75 percent ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)...  Commended for their devotion to personalized service, SMP Pharmacy ... one in the South Florida Business Journal,s 50 Fastest-Growing Companies, ... list, the national specialty pharmacy has found its niche.  To ... soon be honored by SFBJ as the 2017 Power Leader ... to receive his award in October, Bardisa said of the ...
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
Breaking Medicine Technology: