Navigation Links
Children's National Research Links Platelets to Sepsis-Related Organ Failure
Date:3/11/2009

ted States. More than 40 percent of sepsis cases are fatal, and in most, the resulting organ failure, not the underlying infection, is the primary cause of death. Through gene and protein analyses in both septic mice and humans, scientists found that cases of severe sepsis featured a unique attribute: the genes within platelets were triggered to produce a protein known as granzyme B, which has been shown in previous studies to contribute to cell death as part of the body's immune response to cancer and viruses. During sepsis, platelets collect within major organs including the spleen, an important infection-fighting organ. As they collect and come into contact with the organ's cells, the granzyme B, if present, will cause the organ's cells to die. Previous research has shown that that this factor may be a major contributor to organ failure. Granzyme B was only detected in humans and mice with the most severe sepsis.
   
"Detection of granzyme B in platelets could be a huge step forward in battling sepsis," said Dr. Freishtat. "First, as a prognostic indicator, the protein's presence could show more aggressive treatments are needed right off the bat. Eventually, perhaps this knowledge will help us find a way to prevent organ failure by targeting interventions directly at the platelets and granzyme B production."

The study was funded by the National Institutes of Health and Children's National Medical Center. The full manuscript, "Sepsis Alters the Megakaryocyte-Platelet Transcriptional Axis Resulting in Granzyme B-mediated Lymphotoxicity," is at: http://ajrccm.atsjournals.org/cgi/content/abstract/200807-1085OCv1.

Contact: Jennifer Leischer/Emily Dammeyer, 202-476-4500

About Children's National Medical Center
Children's National Medical Center, located i
'/>"/>

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Children's Hospital Central California and CVS/Pharmacy Wheelchair Fund Featured in "Extreme Makeover: Home Edition"
2. Children's Wish, Canada's National Wish Granting Foundation Celebrates 25 Years
3. Ugandan Children Receive Life-Saving Treatment For Heart Defects At Children's National Medical Center
4. Children's National Medical Center Trauma Center Receives Highest Verification from American College of Surgeons
5. Ross University School of Medicine Expands Clinical Rotations at Miami Children's Hospital
6. Children's Museum of Phoenix & Delta Dental of Arizona Foundation Celebrate National Children's Dental Health Month
7. Free Dental Screenings Every Tuesday in February To Celebrate Children's Dental Health Month
8. Pocket Reference Journals Releases Latest Edition of "All About Me" Leading Children's Immunization Journal for New Moms
9. La Rabida Children's Hospital's 13th Annual Symposium to Discuss Outcomes of Premature Birth
10. National Children's Study Begins Recruiting Volunteers
11. Telebriefing: National Children's Study Recruitment Begins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Children's National Research Links Platelets to Sepsis-Related Organ Failure 
(Date:5/27/2015)... The new http://www.carsonenergy.com includes extensive ... consider oil and gas investing, the substantial tax benefits ... industry news, IRA investing, definitions and acronyms, info-graphics and ... and experience is now in one central location, for ... to access 24 hours a day, 7 days a ...
(Date:5/27/2015)... 2015 In support of a ... of the Journal of American Geriatrics Society about the ... Bedford Commons OB-GYN P.A . is reiterating the ... beverages. , To examine the relationship between diet ... Antonio Longitudinal Study of Aging (SALSA) tracked the soda ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 The MedSpa ... three FDA-approved dermal filler treatments in Abilene, Texas: Xeomin®, ... reduce the appearance of glabellar lines, better known as ... Belotero Balance® is designed to treat smoker’s lines around ... the chin, while Radiesse® improves the appearance of smile ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 CompanionDx ... pharmacogenomic and somatic genomic analysis in personalized cancer therapy: ... by the American Society of Clinical Oncology (ASCO) as ... 2 in Chicago. , The molecular and clinical data ... Genome Atlas (TCGA) database. The study reports improved patient ...
(Date:5/27/2015)... Cincinnati Veterans Affairs Women’s Health Clinic in ... Foundation is proud to host the first annual Women Veterans ... 11 at the Freedom Center from 6 p.m. to 10 ... emcee. , This event honors and celebrates women tri-state ... The banquet is free to the first 150 women Veterans ...
Breaking Medicine News(10 mins):Health News:Carson Energy Launches Next Generation Investor Website 2Health News:Recent Study About the Link Between Diet Sodas and Abdominal Fat Reinforces Bedford Commons OB-GYN's Recommendation to Drink Plenty of Water 2Health News:The MedSpa at Hendrick Introduces Xeomin®, Belotero Balance® and Radiesse® Injectables 2Health News:CompanionDx® Analyzes Non-small Cell Lung Cancer Data for Personalized Cancer Therapy 2Health News:CompanionDx® Analyzes Non-small Cell Lung Cancer Data for Personalized Cancer Therapy 3Health News:Cincinnati VA Women’s Health Clinic Celebrates Women Veterans at Awards Banquet 2
... Online Game, Desktop Downloadables and New Videos, Highlight 2008 Additions to Co-Branded ... ... Kids, ATLANTA, April 3, 2008 Building upon its 2007 inaugural,public ... Administration (FDA) today announced an all-new 2008 expanded,edition of the online and ...
... to develop first implantable and external ... pediatric heart pumps, ... -- a national leader in the use of lifesaving,ventricular assist devices ... that recently has been awarded a $2.3 million grant from,the National ...
... for Payers, Providers, and Patients, WASHINGTON, ... Preferred Provider Organizations (AAPPO), in collaboration,with DMAA: ... a diabetes,toolkit for PPO executives to help ... identify effective strategies for improving diabetes,prevention, identification ...
... essential nutrient found in foods such as eggs, is associated ... to a study supported by a grant from the U.S. ... FASEB Journals print issue in June.(1) This study adds to ... a decreased risk of breast cancer. , In this ...
... The American Heart Associations Los Angeles Division today will ... paramedic model in use around the country and one ... Institute at Harbor-UCLA Medical Center (LA BioMed). , The ... to Dr. Criley and William Koenig, Los Angeles County ...
... National Committee on,Quality Assurance (NCQA) has awarded Blue ... Plus Distinction for Physician and Hospital,Quality. The program ... the quality and cost of care provided to ... nonprofit organization dedicated to,measuring the quality of America,s ...
Cached Medicine News:Health News:Cartoon Network and the FDA to Launch Year II Expansion of SPOT THE BLOCK Nutrition Awareness Campaign on Monday, April 7 2Health News:Cartoon Network and the FDA to Launch Year II Expansion of SPOT THE BLOCK Nutrition Awareness Campaign on Monday, April 7 3Health News:Cartoon Network and the FDA to Launch Year II Expansion of SPOT THE BLOCK Nutrition Awareness Campaign on Monday, April 7 4Health News:Children's Hospital of Pittsburgh of UPMC Involved in Projects To Develop Nation's First Heart Assist Devices for Young Children 2Health News:Children's Hospital of Pittsburgh of UPMC Involved in Projects To Develop Nation's First Heart Assist Devices for Young Children 3Health News:AAPPO Releases Diabetes Toolkit to Spur Action on Better Diabetes Care 2Health News:AAPPO Releases Diabetes Toolkit to Spur Action on Better Diabetes Care 3Health News:Essential nutrient found in eggs reduces risk of breast cancer by 24 percent 2Health News:Essential nutrient found in eggs reduces risk of breast cancer by 24 percent 3Health News:Pioneer of paramedic model to be honored 2Health News:Pioneer of paramedic model to be honored 3Health News:NCQA Awards Quality Plus Distinction to Blue Cross and Blue Shield of Minnesota for Physician and Hospital Quality Measures 2
(Date:5/27/2015)... 25, 2015 Research and Markets( http://www.researchandmarkets.com/research/55zkmp/2015_strategies ... "2015 Strategies in the US Flow Cytometry Market" ... report presents a comprehensive analysis of the US ... pertaining to the French flow cytometry practice, as ... technological trends with significant market impact during the ...
(Date:5/27/2015)... DOVER, Delaware , May 27, 2015 ... Delaware corporation engaged in the development and ... a new and novel electrotherapy for the noninvasive treatment ... on May 19, 2015, Zacks Small Cap Research ... found here . According to Zacks, research update, ...
(Date:5/27/2015)... 27, 2015 The Bio-Process Systems Alliance ... Annual International Single-Use Summit (ISUS 2015) will be ... , with a primary focus on the promises ... From technical topics to business and regulatory presentations, ... the emergence of the single-use industry as the "go-to" ...
Breaking Medicine Technology:2015 Strategies in the US Flow Cytometry Market 2Zacks Investment Small Cap Research Issues Quarterly Update on E-QURE 2Zacks Investment Small Cap Research Issues Quarterly Update on E-QURE 3BPSA's 5th Annual Summit to Provide '2020 Vision' for Single-Use Technologies 2BPSA's 5th Annual Summit to Provide '2020 Vision' for Single-Use Technologies 3
... the "Company) (OTCBB: BIAD) today announces settlement of a claim ... pleased to have satisfactorily settled its claim prior to a ... in further cost, distraction and risk to its business. The ... diagnostic device operations. About Bio-AMD, Inc. ...
... Reportlinker.com announces that a new market research ... Global Magnetic Resonance Imaging (MRI) ... This report analyzes the worldwide ... in Units and US$ Million by the ...
Cached Medicine Technology:Bio-AMD, Inc.; Legal Action Settled 2Global Magnetic Resonance Imaging (MRI) Equipment Industry 2Global Magnetic Resonance Imaging (MRI) Equipment Industry 3Global Magnetic Resonance Imaging (MRI) Equipment Industry 4Global Magnetic Resonance Imaging (MRI) Equipment Industry 5Global Magnetic Resonance Imaging (MRI) Equipment Industry 6Global Magnetic Resonance Imaging (MRI) Equipment Industry 7Global Magnetic Resonance Imaging (MRI) Equipment Industry 8Global Magnetic Resonance Imaging (MRI) Equipment Industry 9Global Magnetic Resonance Imaging (MRI) Equipment Industry 10Global Magnetic Resonance Imaging (MRI) Equipment Industry 11Global Magnetic Resonance Imaging (MRI) Equipment Industry 12Global Magnetic Resonance Imaging (MRI) Equipment Industry 13Global Magnetic Resonance Imaging (MRI) Equipment Industry 14Global Magnetic Resonance Imaging (MRI) Equipment Industry 15Global Magnetic Resonance Imaging (MRI) Equipment Industry 16Global Magnetic Resonance Imaging (MRI) Equipment Industry 17Global Magnetic Resonance Imaging (MRI) Equipment Industry 18Global Magnetic Resonance Imaging (MRI) Equipment Industry 19Global Magnetic Resonance Imaging (MRI) Equipment Industry 20Global Magnetic Resonance Imaging (MRI) Equipment Industry 21Global Magnetic Resonance Imaging (MRI) Equipment Industry 22Global Magnetic Resonance Imaging (MRI) Equipment Industry 23Global Magnetic Resonance Imaging (MRI) Equipment Industry 24Global Magnetic Resonance Imaging (MRI) Equipment Industry 25Global Magnetic Resonance Imaging (MRI) Equipment Industry 26Global Magnetic Resonance Imaging (MRI) Equipment Industry 27Global Magnetic Resonance Imaging (MRI) Equipment Industry 28
Inquire...
Inquire...
Flextend is a hydrocolloid skin barrier that is designed to be the most resistant to discharge and is the barrier of choice for urostomies and high output ileosotomies....
Premier pouches provide the ultimate in skin protection with our long wearing Flextend skin barriers and superior comfort with our soft and silky ComfortWear panels....
Medicine Products: