Navigation Links
Childhood viral infection may be a cause of obesity

The emerging idea that obesity may have an infectious origin gets new support in a cross-sectional study by University of California, San Diego School of Medicine researchers who found that children exposed to a particular strain of adenovirus were significantly more likely to be obese.

The study will be published in the September 20 online edition of the journal Pediatrics. September is National Childhood Obesity Awareness Month.

Jeffrey B. Schwimmer, MD, associate professor of clinical pediatrics at UC San Diego, and colleagues examined 124 children, ages 8 to 18, for the presence of antibodies specific to adenovirus 36 (AD36), one of more than 50 strains of adenovirus known to infect humans and cause a variety of respiratory, gastrointestinal and other infections. AD36 is the only human adenovirus currently linked to human obesity.

Slightly more than half of the children in the study (67) were considered obese, based on a Body Mass Index or BMI in the 95th percentile or greater. The researchers detected neutralizing antibodies specific to AD36 in 19 of the children (15 percent). The majority of these AD36-positive children (78 percent) were obese, with AD36 antibodies much more frequent in obese children (15 of 67) than in non-obese children (4 of 57).

Children who were AD36-positive weighed almost 50 pounds more, on average, than children who were AD36-negative. Within the group of obese children, those with evidence of AD36 infection weighed an average of 35 pounds more than obese children who were AD36-negative.

"This amount of extra weight is a major concern at any age, but is especially so for a child," said Schwimmer, who is also director of Weight and Wellness at Rady Children's Hospital in San Diego. "Obesity can be a marker for future health problems like heart disease, liver disease and diabetes. An extra 35 to 50 pounds is more than enough to greatly increase those risks."

Schwimmer said he hopes this research will help shift some of the burden that falls so heavily upon obese people, in particular children.

"Many people believe that obesity is one's own fault or the fault of one's parents or family. This work helps point out that body weight is more complicated than it's made out to be. And it is time that we move away from assigning blame in favor of developing a level of understanding that will better support efforts at both prevention and treatment. These data add credence to the concept that an infection can be a cause or contributor to obesity."

While an association between AD36 and obesity in both animals and human adults has been previously described, the particulars remain poorly understood. For example, it is not known how often or under what circumstances AD36 infects, why the virus affects people differently and whether weight gain is the result of an active infection or a lasting change in a person's metabolism.

In cell cultures, Schwimmer said, the virus infects pre-adipocytes or immature fat cells, prompting them to develop more quickly and proliferate in greater numbers than normal. "This might be the mechanism for obesity," Schwimmer said, "but more work needs to be done."


Contact: Scott LaFee
University of California -- San Diego

Related medicine news :

1. NASBE Supports First Lady Michelle Obama in Fight Against Childhood Obesity
2. Childhood obesity: Its not the amount of TV, its the number of junk food commercials
3. Planting Seeds to Fight Childhood Obesity
4. PolicyLink CEO Angela Glover Blackwell Released the Following Statement on First Lady Michelle Obamas Childhood Obesity Initiative
5. AMA Joins First Lady in Fight Against Childhood Obesity
6. Soothing infants with food focus of childhood obesity study
7. In Support of the Lets Move Campaign to Fight Childhood Obesity, Verizon Thinkfinity Providing Free Educational Resources on Nutrition and Exercise
8. The Alliance for a Healthier Generation Names Celtics Captain Paul Pierce National Athlete Spokesperson in the Fight Against Childhood Obesity
9. New therapeutic target for most common solid cancer in childhood?
10. High Rates of Childhood Leukemia Seen in Iraq Province
11. International study confirms doubling of childhood leukemia rates in southern Iraq
Post Your Comments:
Related Image:
Childhood viral infection may be a cause of obesity
(Date:11/25/2015)... ... November 25, 2015 , ... Brillianteen, ... friendships, and learning in its 65th Anniversary Brillianteen Revue, scheduled for March 4-6, ... , For 65 years, Brillianteen has been a treasured tradition for numerous families ...
(Date:11/25/2015)... ... November 25, 2015 , ... Castlewood Treatment Center for Eating ... disorders as a result of the $20,000 raised at the center’s recent ... Golf Club in Eureka, will help individuals who otherwise might not seek treatment ...
(Date:11/25/2015)... ... November 25, 2015 , ... An unlikely ... resulting in a way for homeless people to have a more dignified and ... new initiative whereby they are repurposing plastic bags into sleeping mats for the ...
(Date:11/25/2015)... ... November 25, 2015 , ... Students and parents have something to be thankful ... Create Real Impact awards. California Casualty is proud to support the contest ... distracted and reckless driving, the number one killer of young drivers. , Almost ...
(Date:11/24/2015)... , ... November 24, 2015 , ... Dr. Todd S. ... offer laser services to many of his patients. Dr. Afferica now uses the BIOLASE ... reduce the amount of time the doctor uses other traditional cutting tools, such as ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015  ARKRAY USA ... continues to provide evidence demonstrating the accuracy of its ... Congress on Insulin Resistance, Diabetes and Cardiovascular Disease in ... both the Company,s GLUCOCARD ® 01 meter and ... accuracy requirements. The ability to accurately measure glucose levels ...
(Date:11/25/2015)... 2015  Trovagene, Inc. (NASDAQ: TROV ), a ... Executive Officer Antonius Schuh, Ph.D., is scheduled to present ... Piper Jaffray Healthcare Conference. th Annual ... Hotel in New York on ... Schuh will be available for one-on-one meetings during the ...
(Date:11/25/2015)... , Nov. 25, 2015 USP ... hazardous drug preparations (e.g. pharmacists, pharmacy technicians, nurses, ... veterinary technicians). The chapter also covers all entities ... (e.g., pharmacies, hospitals, other healthcare institutions, patient treatment ... --> --> What ...
Breaking Medicine Technology: