Navigation Links
Childhood stress such as abuse or emotional neglect can result in structural brain changes

New research using magnetic resonance imaging (MRI) shows that childhood stress such as abuse or emotional neglect, in particular when combined with genetic factors, can result in structural brain changes, rendering these people more vulnerable to developing depression. The study led by scientists at Trinity College Dublin has just been published in the international scientific journal, Neuropsychopharmacology.

Commenting on the significance of the findings, Trinity's Professor Thomas Frodl at the School of Medicine and Trinity Institute for Neuroscience said: "This improved neurobiological understanding shows how stress and genetic variants interact and affect brain structure and function. In turn it demonstrates how it could affect a person's propensity for depression. These structural alterations of the brain are associated with a higher vulnerability to depression and a more chronic course of the depression might be associated with further structural changes".

"Therefore, early intervention in the case of major depression is necessary to increase the chance of a good disease outcome. Fortunately, depression can be treated very well by psychotherapy and antidepressant medication. Moreover, prevention strategies for childhood neglect and misuse are highly important to increase public health and to avoid in later life for these individuals, the burden of major depression."

The world health organisation (WHO) found that major depression is one of the most important human diseases with a prevalence of about 10% worldwide. Approximately 500,000 people in Ireland have or will develop major depression in their life. The WHO has forecast that major depression will be the second most common cause of disability by 2020. Advances in this area will have a high impact on overall disease costs.

The study was conduceted on a total of 24 patients (aged 18-65 years) being treated as inpatients for major depression. They were investigated with high-resolution structural MRI and childhood stress asessments. Special analysis programmes were used to measure brain regions. These patients were compared with 27 healthy control subjects from the local community who were matched for age and gender. Further research is needed in a larger number of patients and controls to identify the underlying causes of depression and stress-gene interaction on brains structure as well as function.


Contact: Caoimhe Ni Lochlainn
Trinity College Dublin

Related medicine news :

1. Genetic predisposition increases childhood asthma risk
2. Treating diabetes during pregnancy can break link to childhood obesity
3. Childhood asthma still inappropriately treated in the UK
4. Screening Proposed for Childhood Cholesterol Levels
5. Success of Shape-Up Somerville Childhood Obesity Intervention to be Presented at the Friedman School Symposium at Tufts, October 29-31, 2007 - Boston
6. Success of Shape Up Somerville childhood obesity intervention to be presented
7. Childhood vaccination may protect adult eyes
8. Childhood Obesity Epidemic a Long-Term Challenge
9. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
10. Antibiotics Not Always Best Bet for Battling Childhood Ear Infections
11. Childhood TV viewing a risk for behavior problems
Post Your Comments:
(Date:12/1/2015)... ... , ... Florida Hospital Tampa is the first health care provider in the region ... , vBloc® Therapy is a vagal blocking therapy, delivered via the Maestro® System, for the ... (BMI) of at least 40 to 45 kg, or a BMI of at least 35 ...
(Date:12/1/2015)... ... , ... Dr. Paul Vitenas, one of the top cosmetic surgeons in ... as the Best Single Physician Practice in the nation. Dr. Vitenas and his practice ... by the industry publication. , Dr. Vitenas said he was very honored to ...
(Date:12/1/2015)... ... 01, 2015 , ... CloudLIMS today announced that it is ... under the New Products and Services category for its innovative product offering, BioTracer. ... that helps labs organize data and track samples with storage inventories. BioTracer's ...
(Date:12/1/2015)... ... December 01, 2015 , ... For ... mark the film for accurate interpretation by the radiologist. The marking utensils are ... from Sacramento, Calif., has found a way to alleviate this problem. , He ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... announced it has been awarded a fixed price per sprint agile development contract ... valued at $34 million over five years, provides software engineering, infrastructure, as well ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 2015 Pharma Tech Outlook recently conducted a ... Data Management Solution Providers - 2015 .  After careful ... CEOs, CIOs, VCs, analysts, and the Pharma Tech Outlook ... top 10 clinical data management solution providers (check out ... and 36 respectively). --> ...
(Date:12/1/2015)... , 1 de diciembre de 2015 ... tecnología para cuchillas de precisión, develó hoy ... de identidad de marca. El nuevo logo ... diseño y la ingeniería de productos con ... diferencia". ...
(Date:12/1/2015)... -- Six months of adjunctive metformin therapy does not improve glycemic ... new research from T1D Exchange and funded by ... effect on measures of obesity, including weight and BMI. The ... of the American Medical Association , are from the largest ... overweight and obese adolescents with type 1 diabetes. ...
Breaking Medicine Technology: