Navigation Links
Childhood maltreatment linked to long-term depression risk and poor response to treatment
Date:8/13/2011

People who have experienced maltreatment as children are twice as likely to develop both multiple and long-lasting depressive episodes as those without a history of childhood maltreatment, according to a new study. The research, led by a team at King's College London Institute of Psychiatry also found that maltreated individuals are more likely to respond poorly to pharmacological and psychological treatment for depression.

The results, to be published in the American Journal of Psychiatry, have emerged from a combined analysis of 16 epidemiological studies involving more than 20,000 participants and of 10 clinical trials involving more than 3,000 participants.

Depression ranks among the most common psychiatric disorders worldwide, with one in ten children exposed to maltreatment including psychological, physical or sexual abuse or neglect. By 2020, depression is predicted to be the second leading contributor to the global burden of disease across all ages, according to the World Health Organisation. The societal impact of depression is largely accounted for by individuals who develop multiple and long-lasting depressive episodes.

Previous research has shown that maltreated individuals are more likely to show abnormalities in biological systems sensitive to psychological stress such as the brain, the endocrine, and the immune system both in childhood and in adult life, which could have important clinical implications.

Dr Andrea Danese, senior investigator of the study at King's says: 'Identifying those at risk of multiple and long-lasting depressive episodes is crucial from a public health perspective. The results indicate that childhood maltreatment is associated both with an increased risk of developing recurrent and persistent episodes of depression, and with an increased risk of responding poorly to treatment.

'Therefore prevention and early therapeutic interventions targeting childhood maltreatment could prove vital in helping prevent the major health burden owing to depression. Knowing that individuals with a history of maltreatment won't respond as well to treatment may also be valuable for clinicians in determining patients' prognosis.'

Dr Danese continues: 'The biological abnormalities associated with childhood maltreatment could potentially explain why individuals with a history of maltreatment respond poorly to treatment for depression.'

Individuals with a history of maltreatment are at elevated risk of mental illness throughout their lives. However, in order to understand how early experiences bring about mental illness, future research should explore biological changes associated with maltreatment before accumulation of multiple depressive episodes.

Dr Rudolf Uher, co-author of the paper, says: 'Our study has shown that antidepressant medication, psychological treatment and the combination of the two are less effective in those who have a history of childhood maltreatment. Whilst we still do not know exactly what type of treatment may improve their care, it may be that new treatments based on the biological vulnerabilities associated with childhood maltreatment could prove an exciting avenue for research.'


'/>"/>

Contact: Katherine Barnes
katherine.barnes@kcl.ac.uk
44-785-091-9019
King's College London
Source:Eurekalert

Related medicine news :

1. Childhood Depression, Anxiety Tied to Pain in Adulthood
2. New Dog Gene May Shed Light on Childhood Epilepsy
3. Stronger social safety net leads to decrease in stress, childhood obesity
4. Epigenetic pathway and new drug show promise in reversing a hard-to-treat childhood cancer
5. Healthy habits linked to childhood obesity in China
6. Ching-Hon Pui, M.D., honored by the American Society of Hematology for work in childhood cancer
7. MU study identifies protective factors that help women recover from childhood violence
8. New therapy for childhood neuroblastoma proves feasible and safe
9. Childhood cancer survivors are at high risk for multiple tumors as they age
10. Slow growth of childhood brain tumors linked to genetic process seen in skin moles
11. Ways to Curb Childhood Obesity Outlined in U.S. Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... April 21, 2017 , ... The Patient Advocacy Community of The Beryl ... 2017 Ruth Ravich Patient Advocacy Award in recognition of her extraordinary contributions ... with the award at The Beryl Institute’s annual Patient Experience Conference on ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Alive ... people who wish to overcome their mental health struggles. The Alive team uses ... LeBouthillier says: “Our approach in dealing with a mental health struggle is based on ...
(Date:4/21/2017)... Ramon, CA (PRWEB) , ... April 21, 2017 , ... ... might not understand the estate planning process, or where to even begin. “Now more ... unresolved if you are to properly protect yourself and your family,” said attorney Lisa ...
(Date:4/21/2017)... ... April 21, 2017 , ... During April 21-23, Super-Sod will join the ... festival offers entertainment for everyone — from the avid gardener to the landscape admirer ... high quality event held in a grand venue, and we are certainly looking forward ...
(Date:4/21/2017)... ... April 21, 2017 , ... MiracleFeet announced today ... years to help end the disability caused by untreated clubfoot in low-income countries. ... Global Clubfoot Initiative to end disability caused by clubfoot worldwide. , ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 Research ... Pharmacogenomics Market Size, Market Share, Application Analysis, Regional Outlook, Growth ... report to their offering. ... The global pharmacogenomics market was valued at US$ 7,167.6 ... Mn by 2024, expanding at a CAGR of 5.6% from ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 Cardiology ... during the projected period The Cardiology Devices segment ... more than US$ 15 Mn in 2018 over 2017. By ... reach a market valuation close to US$ 700 Mn, expanding ... Cardiology Devices segment dominated the Asia Pacific ...
(Date:4/19/2017)... , April 19, 2017  Vanderbilt University Medical Center ... in Nashville , Tennesse have been ... Sphincter Stimulation for GERD (LESS GERD) trial. The EndoStim ... long-term reflux control by restoring normal function to the ... million people in the United States ...
Breaking Medicine Technology: