Navigation Links
Childhood fractures may indicate bone-density problems
Date:1/7/2014

ROCHESTER, Minn. Broken bones may seem like a normal part of an active childhood. About 1 in 3 otherwise healthy children suffers a bone fracture. Breakage of the bone running from the elbow to the thumb side of the wrist (distal forearm fracture) is the most common. It occurs most often during the growth spurt that children typically undergo in early adolescence.

But a recent study at Mayo Clinic, published in the Journal of Bone and Mineral Research, indicates that certain types of fractures may have implications for a child's long-term bone health. The study found evidence that children and adolescents whose forearm fractures occurred due to mild trauma had lower bone strength compared to other children. Lower bone strength may predispose children to factures resulting from weakened bone (osteoporotic fracture) later in life.

"Our study highlights the need for clinicians to consider the level of trauma preceding the injury, when treating children and adolescents who present with fracture," says Joshua Farr, Ph.D., a research fellow at Mayo Clinic in Rochester and lead author of the study. "Fractures from moderate trauma appear more likely to occur in the setting of normal bone strength. But fractures resulting from mild trauma suggest an underlying skeletal deficit."

"We can't say with certainty that these skeletal deficits will track into adulthood. They may be transient," Dr. Farr adds. "But we think that trauma classification is a clinical variable that could be used to more closely monitor kids who are suffering mild-trauma fractures. Intervention in terms of diet and physical activity might be used to optimize bone strength."

The Mayo study compared bone strength in children with recent distal forearm fractures due to mild trauma, children with such fractures due to moderate trauma, and children without fractures. Mild trauma was defined as a fall from a standing height, and moderate trauma was defined as a fall from a relatively low height, such as from a bicycle. The children were aged 8 to 15, and included 108 control participants and 115 boys and girls treated for distal forearm fracture at Mayo within the previous 12 months.

Study participants underwent a sophisticated version of CT known as high-resolution peripheral quantitative computed tomography (HRpQCT) to assess bone strength and quality. Trauma levels were assigned based on clinical notes, radiology reports and interviews with clinicians, parents and patients.

Compared with sex-matched controls, boys and girls with a mild-trauma distal forearm fracture had weaker bones. Their bones were able to tolerate less stress before fracturing, and they had thinner cortical bone the outer layer of bone tissue that carries out most of the functions of bone. The Mayo researchers' methodology differed from that used in previous research that found no difference in bone density in children with mild- and moderate-trauma fractures. That previous work relied on dual energy X-ray absorptiometry (DXA), a 2-dimensional technique that measures bone mass but not bone-tissue density.

"DXA can't measure the structural components of the bone, which are very important contributors to the overall strength of bone," Dr. Farr says.

The previous research also used mailed questionnaires to assess trauma level. "We had very detailed information from the data sources that Mayo allows us to have, so we are confident of our ability to classify the traumas," Dr. Farr says.

The study highlights Mayo's increased emphasis on pediatric research, which led to the recent establishment of the Children's Research Center at Mayo in Minnesota. Funding for the pediatric bone-density study was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and by Mayo's Clinical and Translational Science Award.

The patient studies, which involved fasting blood tests and biochemical assays as well as bone imaging and interviews, were conducted at the outpatient Clinical Research Unit (CRU) at Mayo in Minnesota. "It wouldn't be possible to do this type of clinically intensive study without the infrastructure that's available at the CRU," Dr. Farr says.


'/>"/>

Contact: Colette Gallagher
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Study shows symptoms linked to poor quality of life in long-term childhood
2. Gene Sequencing Project Finds Family of Drugs With Promise for Treating Childhood Tumor
3. Gene sequencing project finds family of drugs with promise for treating childhood tumor
4. Penicillin equally effective as big gun antibiotics for treating less severe childhood pneumonia
5. Former First Lady Laura Bush Speaks at Educational First Steps Inaugural “One Childhood, One Chance” Luncheon
6. Adult Survivors of Childhood Cancer at Risk of Becoming Frail at an Early Age
7. Adult survivors of childhood cancer at risk of becoming frail at an early age
8. SmartPractice Working with Phoenix Children's Hospital Art Project to Fund Childhood Cancer Research
9. Childhood cancer treatment takes toll on hearts of survivors
10. Grandma’s Tips for Child Safety Revealed in New Book "Great Grandma’s Guidelines to Prevent Childhood Accidents"
11. New research on innovative ways to prevent, treat childhood obesity presented at AAP conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses ... human interest stories, courtesy of leaders in the nursing and health care industry. ... from leading advocates and associations—namely Jones & Bartlett Learning. , Jones & Bartlett ...
(Date:5/27/2016)... ... ... With a team of certified experts, Validation Center is ... GMP accreditation, Validation Center is also a registered authority of the international system ... Validation Center is ISO17025 accredited and only offers its clients the latest technology, ...
(Date:5/26/2016)... ... May 26, 2016 , ... W.S. Badger Co. Inc ., the maker ... 2016 When Work Works Award for its use of effective workplace strategies to increase ... Works project administered by the Families and Work Institute (FWI) and the Society for ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... property (IP) to its specialty academic programs. , Answering to the increasing demand ... certificate programs in health law, and environmental and land use law. ,  , ...
(Date:5/26/2016)... ... , ... The Woodlands at John Knox Village , Florida’s first Life ... living and healing, celebrated its grand opening, today. The Woodlands at John Knox Village ... Empowered Staff. , “This is an incredibly fulfilling time for John Knox Village as ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... Market by Type (3D, 2D, 4D), by Therapeutic Area ... by End User (Medical Device Manufacturers, Hospitals/ Clinics) - ... the global Medical Animation Market for the forecast period ... reach USD 301.3 Million by 2021 from USD 117.3 ...
(Date:5/25/2016)...  Zymo Research Corp. announced today the final ... that help researchers obtain the most accurate and ... rapid growth of the study of microbiomes has ... methods to improve the reproducibility and quality of ... every step of the measurement process including collection ...
(Date:5/25/2016)... 2016 As illustrated by the ... month, the numbers and momentum of cannabis in the ... the billions, more research and development push the sector ... of Legal Marijuana Markets Report  from from ArcView Market ... of the increase in sector is attributed to adult ...
Breaking Medicine Technology: