Navigation Links
Childhood epilepsy research offers new hope for seizure control
Date:10/22/2007

Scientists still do not know what causes epileptic seizures, but researchers from Melbournes Howard Florey Institute are one step closer to solving this puzzle with the help of their newly developed genetically modified epileptic mouse.

This is the first human genetic mutation based mouse model in the world that mimics childhood absence epilepsy (CAE). The mouse is now helping Dr Steven Petrou and his team to understand the genesis of epilepsy, which will aid in the development of better anti-seizure drugs.

CAE involves brief staring spells, during which the child is not aware or responsive. These episodes can occur one to 50 times per day and the age of onset is usually three to 10 years.

In about 30% of people, anti-epileptic drugs do not adequately control their seizures and many drugs have side-effects such as rashes, lethargy and memory problems.

Dr Petrou said new treatment strategies were urgently needed to create beneficial drugs without side-effects.

The problem with current drugs is that they treat the symptoms, not the root cause, Dr Petrou said.

To develop new treatment strategies we need to understand the genesis of epilepsy, and this mouse model should provide a window into that fundamental process.

We all know seizures occur if the brains cortex goes haywire, but something is happening prior to that event to cause neurons to misfire, and we want to understand that initial event.

Because mice grow so quickly, changes in the brain can be readily seen and measured.

In a week the mouse can go from no seizures to seizures, so we can investigate what changes are occurring in that period and what is happening in the critical time window that leads to seizures.

Initial findings suggest there is a defect in the brains cortex which may be related to the beginning of seizures in CAE but we are delving into deeper brain structures as well, Dr Petrou said.

The inherited human gene mutation that causes CAE was first detected by Dr Petrous collaborator, Prof Samuel Berkovic from Austin Health. Through genetic manipulation, Dr Petrou has introduced this human mutation into the mouse DNA, allowing the researchers to study a mouse version of the human condition.

The mutation itself is rare in humans but it causes CAE, which is one of the more common forms of epilepsy.

Dr Petrou said that modelling genetic epilepsies in mice will allow researchers to understand epilepsy from the molecular level all the way through to physical behaviour.

Creating this link in the human brain is impossible due to the highly invasive methodology required, so mouse models provide us with a unique opportunity to discover mechanisms of seizure genesis, Dr Petrou added.


'/>"/>

Contact: Merrin Rafferty
merrin.rafferty@florey.edu.au
61-383-441-658
Research Australia
Source:Eurekalert

Related medicine news :

1. Focused Treatment For Childhood Cancer
2. Osteoporosis associated with Childhood Cancer
3. Stroke also in list of common childhood ailments
4. Asthma is not just a childhood condition
5. Asthma not just a childhood condition
6. Childhood Sunburn Can Lead to Skin Cancer Later
7. Preventing Childhood Deaths
8. Radiation Not Needed for Childhood Cancers
9. Troubled Childhood found to affect your Liver
10. Elevated LDL levels in Childhood could be Predictors of Heart Disease
11. Persistent Childhood Wheeze Probably Inherited
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... AccentCare, a leader in post-acute health care, have expanded their existing home health ... Home Health. , AccentCare has been operating a joint venture home health company ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
(Date:10/12/2017)... ... 2017 , ... Leading pediatric oncology experts at Children’s National Health System ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
(Date:10/12/2017)... ... 12, 2017 , ... In the United States, single-family home ... states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is ... low property-tax rates, which contributes to the relatively lower cost of living in ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... SEOUL, South Korea , Oct. 4, 2017 /PRNewswire/ ... launched its next-generation CPR training aide "cprCUBE" on Kickstarter. ... of chest compression during cardiac arrests with better efficiency ... patient-mannequins. It also offers real-time feedback on efficacy of ... The crowdfunding campaign has a goal to raise ...
(Date:10/2/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... , and named its founder as Diplomat,s chief information ... Tennessee , will operate under Diplomat subsidiary Envoy ... for health care partners to include IT outsourcing, consulting, ... "In an interoperable world, technology delivers comprehensive insight and ...
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
Breaking Medicine Technology: