Navigation Links
Childhood epilepsy research offers new hope for seizure control
Date:10/22/2007

Scientists still do not know what causes epileptic seizures, but researchers from Melbournes Howard Florey Institute are one step closer to solving this puzzle with the help of their newly developed genetically modified epileptic mouse.

This is the first human genetic mutation based mouse model in the world that mimics childhood absence epilepsy (CAE). The mouse is now helping Dr Steven Petrou and his team to understand the genesis of epilepsy, which will aid in the development of better anti-seizure drugs.

CAE involves brief staring spells, during which the child is not aware or responsive. These episodes can occur one to 50 times per day and the age of onset is usually three to 10 years.

In about 30% of people, anti-epileptic drugs do not adequately control their seizures and many drugs have side-effects such as rashes, lethargy and memory problems.

Dr Petrou said new treatment strategies were urgently needed to create beneficial drugs without side-effects.

The problem with current drugs is that they treat the symptoms, not the root cause, Dr Petrou said.

To develop new treatment strategies we need to understand the genesis of epilepsy, and this mouse model should provide a window into that fundamental process.

We all know seizures occur if the brains cortex goes haywire, but something is happening prior to that event to cause neurons to misfire, and we want to understand that initial event.

Because mice grow so quickly, changes in the brain can be readily seen and measured.

In a week the mouse can go from no seizures to seizures, so we can investigate what changes are occurring in that period and what is happening in the critical time window that leads to seizures.

Initial findings suggest there is a defect in the brains cortex which may be related to the beginning of seizures in CAE but we are delving into deeper brain structures as well, Dr Petrou said.

The inherited human gene mutation that causes CAE was first detected by Dr Petrous collaborator, Prof Samuel Berkovic from Austin Health. Through genetic manipulation, Dr Petrou has introduced this human mutation into the mouse DNA, allowing the researchers to study a mouse version of the human condition.

The mutation itself is rare in humans but it causes CAE, which is one of the more common forms of epilepsy.

Dr Petrou said that modelling genetic epilepsies in mice will allow researchers to understand epilepsy from the molecular level all the way through to physical behaviour.

Creating this link in the human brain is impossible due to the highly invasive methodology required, so mouse models provide us with a unique opportunity to discover mechanisms of seizure genesis, Dr Petrou added.


'/>"/>

Contact: Merrin Rafferty
merrin.rafferty@florey.edu.au
61-383-441-658
Research Australia
Source:Eurekalert

Related medicine news :

1. Focused Treatment For Childhood Cancer
2. Osteoporosis associated with Childhood Cancer
3. Stroke also in list of common childhood ailments
4. Asthma is not just a childhood condition
5. Asthma not just a childhood condition
6. Childhood Sunburn Can Lead to Skin Cancer Later
7. Preventing Childhood Deaths
8. Radiation Not Needed for Childhood Cancers
9. Troubled Childhood found to affect your Liver
10. Elevated LDL levels in Childhood could be Predictors of Heart Disease
11. Persistent Childhood Wheeze Probably Inherited
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: