Navigation Links
Childhood cancer survivors face long-term risk of GI complications, study finds
Date:10/22/2010

BOSTONPeople treated for cancer when they were children have a higher-than-average risk of gastrointestinal problems some mild, some quite severe in the years following treatment, according to a study to be presented at the 42nd Congress of the International Society of Paediatric Oncology (SIOP) in Boston on Sunday, Oct. 24. Investigators at Dana-Farber/Children's Hospital Cancer Center and their colleagues say their findings suggest that childhood cancer survivors and their physicians should be especially aware of the increased likelihood of gastrointestinal troubles and factor them into plans for monitoring survivors' health.

"Current treatments have dramatically increased survival rates for children with cancer, but we know that many cancer therapies including surgery, radiation, and chemotherapy can cause significant gastrointestinal [GI] complications for patients," says the study's senior author, Lisa Diller, MD, director of the Perini Family Survivors Center at Dana-Farber. "Little is known, however, about the long-term GI consequences for childhood cancer survivors."

To identify such delayed effects, researchers searched for instances of upper GI (esophageal, stomach) problems, liver disorders, and lower GI (intestinal) problems in 14,358 participants in the Childhood Cancer Survivor Study, which tracks the health of children diagnosed with cancer between 1970 and 1986 who survived at least five years after treatment. Rates of GI disorders in these survivors were compared to rates in a randomly selected group of their siblings.

Most of the survivors had received chemotherapy, and about a third had received radiation and/or chemotherapy. Researchers found that the survivors had an elevated risk for upper GI complications such as ulcers, indigestion, heartburn, esophagus problems, nausea, and vomiting; for liver conditions such as cirrhosis, gallstones, and jaundice (and were 24 percent more likely than siblings to have needed a liver biopsy); and for lower GI problems such as colitis, constipation, diarrhea, and intestinal polyps or blockage. In general, survivors who were diagnosed at an older age and had more intensive radiation and/or chemotherapy and more extensive surgery had higher rates of these complications.

These increased risks make it important for survivors to inform their physicians of their earlier cancer treatment, and for physicians to consider whether GI problems are symptoms of a more serious disease in these patients, Diller states. In recent years, pediatric oncologists have worked to develop lower-dose treatments and less invasive surgical procedures to reduce the long-term consequences of childhood cancer therapy, she adds.


'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Related medicine news :

1. Medicaid reimbursement and childhood flu vaccination rates linked
2. Brain imaging identifies differences in childhood bipolar disorder, ADHD
3. X-rays linked to increased childhood leukemia risk
4. A Dog May Help Guard Against Childhood Eczema
5. Women and Infants provides fertility preservation for childhood cancer survivors
6. Childhood Obesity Might Be Linked to Strain of Cold Virus
7. Childhood viral infection may be a cause of obesity
8. Childhood cancer survivors show sustained benefit from common ADHD medication
9. NYU Langone scientists find key pathway implicated in progression of childhood cancer
10. Some Minority Groups Hit Hard by Childhood Obesity
11. Adversity in childhood can increase risk of cardiovascular disease in adulthood, research shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... July 20, 2017 , ... ... headquartered in Houston, is pleased to announce their expansion to the Midwest with ... experience, directors Alysse Hollis and Ronald Bell, and of counsels, John Peck and ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... Team Type ... access to medicine for everyone affected by diabetes, is teaming up with a Microsoft ... global event kicks off on July 24th. , “Team Type 1’s mission overlaps ...
(Date:7/20/2017)... ... ... Girl Up Campaign Director, Melissa Kilby, released the statement ... providing girls access to education in refugee settings. In May, Congressman Steve Chabot (R-OH) ... Education in Vulnerable Settings Act.” Yesterday, companion legislation was introduced in the Senate ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... two products that further expand its existing adherence automation lines. The ATP® Mini ... mirror the advanced technology of TCG’s standard products, but at a size and ...
(Date:7/20/2017)... ... July 20, 2017 , ... With nearly ... top travel insurance solution company VisitorsCoverage Inc. has launched TMQuotes, a new cloud-based ... travel insurance products online, under their own brand. The online marketplace bridges the ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... -- US medical equipment and supply demand is forecast to ... Medical Equipment & Supplies: United States , a ... in demand for medical services – driven in large ... by gains in disposable personal income – will boost ... will also drive sales as providers and patients seek ...
(Date:7/10/2017)... N.C. , July 10, 2017 Locus ... Convertible Note to support the development of CRISPR-Cas3 antimicrobial ... Holdings Limited, a leading Chinese Internet services provider, and ... will advance multiple infectious disease product programs targeting antibiotic ... Founded by Dr. Rodolphe Barrangou ...
(Date:7/5/2017)... , July 5, 2017 Pace Analytical, a company of over ... today that they have acquired ESC Lab Sciences, further solidifying their position as ... United States . ... Steve Vanderboom- President and CEO of Pace Analytical ... ESC Lab Sciences out of Mt Juliet, TN , enhances ...
Breaking Medicine Technology: