Navigation Links
Childhood cancer survivors face long-term risk of GI complications, study finds
Date:10/22/2010

BOSTONPeople treated for cancer when they were children have a higher-than-average risk of gastrointestinal problems some mild, some quite severe in the years following treatment, according to a study to be presented at the 42nd Congress of the International Society of Paediatric Oncology (SIOP) in Boston on Sunday, Oct. 24. Investigators at Dana-Farber/Children's Hospital Cancer Center and their colleagues say their findings suggest that childhood cancer survivors and their physicians should be especially aware of the increased likelihood of gastrointestinal troubles and factor them into plans for monitoring survivors' health.

"Current treatments have dramatically increased survival rates for children with cancer, but we know that many cancer therapies including surgery, radiation, and chemotherapy can cause significant gastrointestinal [GI] complications for patients," says the study's senior author, Lisa Diller, MD, director of the Perini Family Survivors Center at Dana-Farber. "Little is known, however, about the long-term GI consequences for childhood cancer survivors."

To identify such delayed effects, researchers searched for instances of upper GI (esophageal, stomach) problems, liver disorders, and lower GI (intestinal) problems in 14,358 participants in the Childhood Cancer Survivor Study, which tracks the health of children diagnosed with cancer between 1970 and 1986 who survived at least five years after treatment. Rates of GI disorders in these survivors were compared to rates in a randomly selected group of their siblings.

Most of the survivors had received chemotherapy, and about a third had received radiation and/or chemotherapy. Researchers found that the survivors had an elevated risk for upper GI complications such as ulcers, indigestion, heartburn, esophagus problems, nausea, and vomiting; for liver conditions such as cirrhosis, gallstones, and jaundice (and were 24 percent more likely than siblings to have needed a liver biopsy); and for lower GI problems such as colitis, constipation, diarrhea, and intestinal polyps or blockage. In general, survivors who were diagnosed at an older age and had more intensive radiation and/or chemotherapy and more extensive surgery had higher rates of these complications.

These increased risks make it important for survivors to inform their physicians of their earlier cancer treatment, and for physicians to consider whether GI problems are symptoms of a more serious disease in these patients, Diller states. In recent years, pediatric oncologists have worked to develop lower-dose treatments and less invasive surgical procedures to reduce the long-term consequences of childhood cancer therapy, she adds.


'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Related medicine news :

1. Medicaid reimbursement and childhood flu vaccination rates linked
2. Brain imaging identifies differences in childhood bipolar disorder, ADHD
3. X-rays linked to increased childhood leukemia risk
4. A Dog May Help Guard Against Childhood Eczema
5. Women and Infants provides fertility preservation for childhood cancer survivors
6. Childhood Obesity Might Be Linked to Strain of Cold Virus
7. Childhood viral infection may be a cause of obesity
8. Childhood cancer survivors show sustained benefit from common ADHD medication
9. NYU Langone scientists find key pathway implicated in progression of childhood cancer
10. Some Minority Groups Hit Hard by Childhood Obesity
11. Adversity in childhood can increase risk of cardiovascular disease in adulthood, research shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... ... of corrosive ions found in power plant water and steam. , Chlorides and ... turbines and boilers, leading to extensive maintenance and unplanned shutdowns. Monitoring these ions ...
(Date:3/28/2017)... ... March 28, 2017 , ... The Executives, Staff & Clients of ... for the Toys for Tots Literacy Campaign at their Semi-Annual Graduation and Fundraiser Event ... billion, the U.S. ranks at number 14 internationally in literacy. Statistically, a direct relation ...
(Date:3/28/2017)... ... 2017 , ... A minimally invasive porcelain veneer is increasing ... Association of Dental Laboratories (NADL) is informing dentists about the benefits of minimally ... dental laboratories and technicians that create these veneers. , According to National ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... Liu of SkyLex Advanced Surgical, Inc. is thrilled to offer the recently FDA-approved ... procedure, and this procedure adds to SkyLex Advanced Surgical’s already comprehensive list ...
(Date:3/28/2017)... Atlantic City, NJ (PRWEB) , ... March 28, ... ... annual American Camp Association’s Tri-State Camp Conference in Atlantic City March 13-16, was ... partners, and their team of professional staff discussed strategies for preventing outbreaks among ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... TEL AVIV, Israel , March 28, 2017 ... Israel . This new business entity, Emosis Ltd, headquartered in ... research and development of novel assays complementing the mother company existing ... locally support commercialization and sales development of Emosis kits. ... This strategic move starts building ...
(Date:3/28/2017)... 2017 The global surgical ... value of USD 4.5 billion by 2025, according to ... closure of injured tissues post operation is a major ... occur in 3% to 15% of cases and are ... one third of postoperative deaths in patients. Surgical sealants ...
(Date:3/27/2017)... , March 27, 2017 ... better understand Bayer and its partnering interests and activities since ... report provides an in-depth insight into the partnering activity of ... On demand company reports are prepared upon purchase to ensure ... data. The report will be delivered in PDF ...
Breaking Medicine Technology: