Navigation Links
Childhood cancer survivors face long-term risk of GI complications, study finds
Date:10/22/2010

BOSTONPeople treated for cancer when they were children have a higher-than-average risk of gastrointestinal problems some mild, some quite severe in the years following treatment, according to a study to be presented at the 42nd Congress of the International Society of Paediatric Oncology (SIOP) in Boston on Sunday, Oct. 24. Investigators at Dana-Farber/Children's Hospital Cancer Center and their colleagues say their findings suggest that childhood cancer survivors and their physicians should be especially aware of the increased likelihood of gastrointestinal troubles and factor them into plans for monitoring survivors' health.

"Current treatments have dramatically increased survival rates for children with cancer, but we know that many cancer therapies including surgery, radiation, and chemotherapy can cause significant gastrointestinal [GI] complications for patients," says the study's senior author, Lisa Diller, MD, director of the Perini Family Survivors Center at Dana-Farber. "Little is known, however, about the long-term GI consequences for childhood cancer survivors."

To identify such delayed effects, researchers searched for instances of upper GI (esophageal, stomach) problems, liver disorders, and lower GI (intestinal) problems in 14,358 participants in the Childhood Cancer Survivor Study, which tracks the health of children diagnosed with cancer between 1970 and 1986 who survived at least five years after treatment. Rates of GI disorders in these survivors were compared to rates in a randomly selected group of their siblings.

Most of the survivors had received chemotherapy, and about a third had received radiation and/or chemotherapy. Researchers found that the survivors had an elevated risk for upper GI complications such as ulcers, indigestion, heartburn, esophagus problems, nausea, and vomiting; for liver conditions such as cirrhosis, gallstones, and jaundice (and were 24 percent more likely than siblings to have needed a liver biopsy); and for lower GI problems such as colitis, constipation, diarrhea, and intestinal polyps or blockage. In general, survivors who were diagnosed at an older age and had more intensive radiation and/or chemotherapy and more extensive surgery had higher rates of these complications.

These increased risks make it important for survivors to inform their physicians of their earlier cancer treatment, and for physicians to consider whether GI problems are symptoms of a more serious disease in these patients, Diller states. In recent years, pediatric oncologists have worked to develop lower-dose treatments and less invasive surgical procedures to reduce the long-term consequences of childhood cancer therapy, she adds.


'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Related medicine news :

1. Medicaid reimbursement and childhood flu vaccination rates linked
2. Brain imaging identifies differences in childhood bipolar disorder, ADHD
3. X-rays linked to increased childhood leukemia risk
4. A Dog May Help Guard Against Childhood Eczema
5. Women and Infants provides fertility preservation for childhood cancer survivors
6. Childhood Obesity Might Be Linked to Strain of Cold Virus
7. Childhood viral infection may be a cause of obesity
8. Childhood cancer survivors show sustained benefit from common ADHD medication
9. NYU Langone scientists find key pathway implicated in progression of childhood cancer
10. Some Minority Groups Hit Hard by Childhood Obesity
11. Adversity in childhood can increase risk of cardiovascular disease in adulthood, research shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... WACO, Texas (PRWEB) , ... May 02, 2016 , ... ... Corporation will offer an incentive to people who share their fitness journey on ... footwear and premium first aid products, will award a $100 product voucher each week ...
(Date:5/2/2016)... New York, NY (PRWEB) , ... May 02, 2016 , ... ... Highlighting the year’s best in pet gear and toys, leading product review site ... TTPM Pets Paw of Excellence Awards at their Spring Showcase at the Metropolitan ...
(Date:5/2/2016)... Netherlands (PRWEB) , ... May 02, 2016 , ... Further ... honored to announce that the new WHIMZEES Variety Value Boxes were selected from over ... New Product Showcase Award. , WHIMZEES natural dental chews for dogs are a ...
(Date:5/2/2016)... Rafael, CA (PRWEB) , ... May 02, 2016 , ... The 2016 World Ultimate & ... Nike Ultimate Camp at Manhattan College, made the cut. The WUGC is being held in ... National Teams won the gold in the men’s division, another gold in the women’s masters ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... (AAC) event, will be held at the Bellagio Hotel in Las Vegas, NV ... Social Work (NASW) will be co-hosting the event. , This year’s conference will ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... 2016  Celsion Corporation (NASDAQ: CLSN ), ... from the first cohort of patients in its ... Study) combining GEN-1, the Company,s DNA-based immunotherapy, with ... newly-diagnosed patients with advanced ovarian cancer who will ... In the first three patients dosed, GEN-1 plus ...
(Date:4/29/2016)... , April 29, 2016 /PRNewswire/ ... Contamine, Directeur Financier Sanofi, ... santé, publie ses résultats pour le ... du Groupe, Jérôme Contamine, commente les ... et les perspectives pour le reste ...
(Date:4/28/2016)... -- Research and Markets has announced the ... 2016-2020" report to their offering.      ... global plastic surgery products market is expected to grow ... , ,The growing adoption of laser in aesthetics is ... market. Lasers are used to treat a broad range ...
Breaking Medicine Technology: