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Childhood cancer survivors at increased risk of certain tumors in middle-age
Date:6/4/2011

In a study that included nearly 18,000 children who had cancer, with follow-up of about 25 years, the greatest excess risk associated with a subsequent primary neoplasm (a new tumor) at older than age 40 years was for digestive and genitourinary neoplasms (related to the genital or urinary tract organs), according to a study in the June 8 issue of JAMA, a theme issue on cancer. The study is being published early online to coincide with the American Society of Clinical Oncology 2011 Annual Meeting.

"Survivors of childhood cancer are at increased risk of developing subsequent primary neoplasms with the risk being estimated at 3- to 6-fold than expected. However, the magnitude of the long-term risks of developing a subsequent primary neoplasm, in particular beyond ages at which the background cancer incidence in the general population starts to increase substantially, are unknown," according to background information in the article. "It is essential to investigate the long-term risks of subsequent primary neoplasms since any increased relative risk (RR) sustained into old age would lead to a substantial number of survivors being diagnosed with a subsequent primary neoplasm. To reduce the number of subsequent primary neoplasms, prevention, screening, and other intervention strategies should focus on subsequent primary neoplasm types with the highest absolute excess risks (AERs); however, it is currently unclear which subsequent primary neoplasm types contribute most to the total AER, particularly at older than 40 years."

Raoul C. Reulen, Ph.D., of the University of Birmingham, Edgbaston, United Kingdom, and colleagues conducted a study to investigate the long-term risks of subsequent primary neoplasms in survivors of childhood cancer. The British Childhood Cancer Survivor Study included 17,981 5-year survivors of childhood cancer diagnosed with cancer at younger than 15 years between 1940 and 1991 in Great Britain, who were followed up thro
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Contact: Raoul C. Reulen, Ph.D.
r.c.reulen@bham.ac.uk
JAMA and Archives Journals
Source:Eurekalert

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