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Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications
Date:5/4/2011

ific combinations of chemotherapy, radiation and surgery have dramatically improved survival, these treatment modalities have the potential to cause significant GI complications. For example, abdominal radiation often results in several acute toxicities, including intestinal inflammation and abnormal movement of the intestinal tract. Chemotherapy is associated with many acute GI toxicities, including nausea, vomiting, diarrhea, constipation and increased susceptibility to GI infections. Intra-abdominal surgery and subsequent GI complications are also contributors to GI toxicity of cancer therapy. Long-term GI consequences, however, have not been extensively studied.

In this study, doctors evaluated the incidence of long-term GI outcomes and identified treatment-related risk factors. The goals of this analysis were to describe the incidence of self-reported adverse GI conditions occurring at least five years after diagnosis and to evaluate the effect of different treatment-associated factors on the risk of developing these GI events.

Upper GI, lower GI and liver adverse outcomes were assessed in cases from participants in the Childhood Cancer Survivor Study, a study of 14,358 survivors of childhood cancer (i.e., leukemias, brain tumors, lymphomas, Wilms tumor, neuroblastoma, sarcomas and bone tumors) who were diagnosed between 1970 and 1986 at one of 26 collaborating institutions in the U.S. and Canada; data were compared with those from randomly selected siblings. The median age at cancer diagnosis was 6.8 years, and the median age at outcome assessment was 23.2 years for survivors and 26.6 years for siblings.


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Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

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