Navigation Links
Childhood brain tumor traced to normal stem cells gone bad
Date:8/11/2008

ren between 2 and 5 years of age, affect the brain's cerebellum region, which is involved in controlling body movements. They make up about 30 percent of childhood brain tumors, and account for 250 to 300 new cases per year.

With current treatments, approximately 60 to 70 percent of patients live at least five years, but often they are left with cognitive disabilities from surgery, chemotherapy and radiation, urgently suggesting a need for new, more-selective therapies.

"Medulloblastoma was one of the first tumors that was believed to fit the hypothesis that tumors are caused by 'cancer stem cells' that initiate malignancies and sustain them," said Ligon, who is also on faculty and an assistant professor at Harvard Medical School. "But the prevailing hypothesis -- that medulloblastomas originate from non-stem cells just did not make perfect sense with this."

The discoveries emerged from a series of experiments begun in the Rowitch Laboratory at Dana-Farber. The initial goal was to determine whether activating the Sonic hedgehog cancer pathway in multiple types of brain cells, including neural stem cells, could help pinpoint which cells brain cancers might come from. Surprisingly, the scientists generated just one tumor type, medulloblastoma, regardless of whether they activated the pathway in stem cells for other cell types called neurons and glia. This was a surprise: it had been thought that medulloblastoma arose purely from neuronal ("thinking") cells and not "glial" or supporting cells.

An intriguing question for the investigators is why these cells, known as granule neuron precursors, seem to be uniquely vulnerable to the tumor-triggering effects of the Sonic hedgehog pathway, while other brain stem and progenitor cells are not.

Explained Rowitch: "There must be susceptibility factors in the granule neuron precursor cell that predispose it to forming cancer, so we now must try to understand what it is about this c
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. One-Fifth of British Childhood Cancer Survivors Smoke
2. String probes for devastating childhood digestive disease
3. 1/5 of British adult survivors of childhood cancer smoke despite hazards
4. YMCA Calls on Senate to Fund Community-Based Solutions to Address Childhood Obesity Crisis
5. St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease
6. From Jet Engines to Search Engines, ORBIS-FedEx-Indiana University Join Forces to Fight Unnecessary Childhood Blindness
7. Aggressive treatment of childhood eczema could help prevent asthma, says new study
8. Topical oral syrup prevents early childhood caries
9. Stress during childhood increases the risk of allergies
10. U of M sets course for cure of fatal childhood skin disease
11. New Program/Website Targets Jewish Children, Teens, and Adults Suffering from the Impact of Childhood Maltreatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... (PRWEB) September 30, 2014 For most ... the apple orchard, pumpkin patch or annual festival. For ... fast-spreading viruses – like the respiratory infection Enterovirus D68. ... most children, a small percentage – especially children with ... Increased concern about the Enterovirus is prompting hospitals across ...
(Date:9/30/2014)... Columbus, Ohio (PRWEB) September 30, 2014 ... and new viral strains emerging every day, it’s ... disinfecting system. The EnviroShield system is an ... and allows applications to surface normally missed with ... a spray nozzle that adds an electrostatic negative ...
(Date:9/30/2014)... A group of Americans is headed to ... that, left unchecked, could create a catastrophic, global pandemic. No, ... Africa. John Rogers, the Executive Director the Eugene Bell Foundation ... a disease most think mankind conquered long ago: tuberculosis. , ... is on the comeback in several countries - what’s especially ...
(Date:9/30/2014)... Two revolutionary procedures now being utilized by ... disease a far less painful and far more effective ... ever felt electric shock waves surge through your teeth as ... it’s possible you already know the impact of receding gums,” ... dentist in West Palm Beach, and a Fellow in the ...
(Date:9/30/2014)... TUESDAY, Sept. 30, 2014 (HealthDay News) -- Medicare should ... at high risk for the disease, a coalition of ... The coalition, which includes the Lung Cancer Alliance, the ... the American Cancer Society and the American Society of ... Monday to the U.S. Centers for Medicare & Medicaid ...
Breaking Medicine News(10 mins):Health News:As Hospitals Combat Enterovirus Outbreaks, Patients and Families Turn to “Virtual Visits” with CaringBridge 2Health News:Columbus Janitorial Company Announces New Disinfecting System for your workplace 2Health News:US Delegation Heads to North Korea to Combat Tuberculosis Epidemic 2Health News:Florida Dentist Battles Gum Disease With Latest Techniques 2Health News:Florida Dentist Battles Gum Disease With Latest Techniques 3Health News:Groups Call for Medicare Coverage of Lung Cancer Screening 2
... By Alan Mozes HealthDay Reporter , THURSDAY, March ... a common facet of dating for America,s adolescents, a new ... graders found that more than 37 percent of 11- to ... psychological violence, and almost one in six said they had ...
... (HealthDay News) -- Although eight states boosted their sales taxes ... in the number of such increases by states compared to ... Control and Prevention shows. One thing that smoking prevention ... as cigarette prices go up, the CDC said. ...
... common kidney cancer subtype, face a low risk of tumour ... findings of a multi-centre study of nearly 600 patients published ... . "Because papillary renal cell carcinoma ... the small number of patients enrolled in individual studies makes ...
... , WEDNESDAY, March 28 (HealthDay News) -- Tourists over age 65 ... die from the disease than those ages 18 to 35, a ... from more than 25,000 U.K. patients also found that the malaria ... West Africa. The risk of dying from malaria, an infection ...
... As part of an isolated indigenous group in central ... fishing, and clearing land by hand to grow crops. Their ... day might imply they have higher than average male testosterone ... of Washington have found, however, that the baseline testosterone level ...
... the World Health Organization (WHO) estimates that 20.1 million ... 1 and 2 across 9 world regions in 2005. ... Hepatology , a journal published by Wiley-Blackwell on ... Liver Diseases, there were 3.4 million symptomatic cases, 70,000 ...
Cached Medicine News:Health News:Dating Violence Common by 7th Grade: Survey 2Health News:Dating Violence Common by 7th Grade: Survey 3Health News:States' Efforts to Boost Cigarette Taxes Slows: CDC 2Health News:Kidney cancer subtype study finds low recurrence and cancer death rates 2Health News:Older Travelers at Much Higher Risk of Dying From Malaria 2Health News:Low testosterone level in Amazonian tribe responds to competition 2Health News:Over 20 million individuals infected with hepatitis E in Asia and Africa 2
(Date:9/30/2014)... 2014  Tasly Pharmaceuticals, Inc., the world,s leader ... today the launch of Deepure. Deepure ... men and women concerned with supporting their overall ... age while helping keep their health care cost ... herb-based formulas, namely, ProHeart PLUS, ImmunoPower PLUS, and ...
(Date:9/30/2014)... Arbor Pharmaceuticals, LLC. - Product Pipeline ... Direct,s, ,Arbor Pharmaceuticals, LLC. - Product Pipeline Review ... Pharmaceuticals, LLC.,s pharmaceutical research and development focus. ... therapeutic developmental pipeline of Arbor Pharmaceuticals, LLC.,s, complete ... by drug target, mechanism of action (MoA), route ...
(Date:9/30/2014)... Mass. , Sept. 30, 2014  Decision Resources Group finds ... Australia , China , ... Korea—will expand at a strong rate through 2023. Dental implant procedure ... and as patient awareness rises. Other key findings from ... dental implant market: , Dental implant penetration: ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3
... Comfort Pick one of our pipettors up ... trigger and ejector positionsright where they should beeven ... ergonomically designed to help avoid repetitive stress injuries ... In The Palm Of Your Hand Start ...
... Pick one of our pipettors up and ... and ejector positionsright where they should beeven if ... designed to help avoid repetitive stress injuries caused ... The Palm Of Your Hand Start dispensing ...
... total ergonomic solution and best value in ... touch action and ultra lightweight design reduce ... ejection with long, lever tip ejector , ... Accepts universal tips or for greater performance ...
... The Finnpipette BioControl multichannel ... features as the single ... handle fits allseven multichannel ... tip cone modules. Both ...
Medicine Products: