Navigation Links
Childhood brain tumor traced to normal stem cells gone bad
Date:8/11/2008

BOSTON--An aggressive childhood brain tumor known as medulloblastoma originates in normal brain "stem" cells that turn malignant when acted on by a known mutant, cancer-causing oncogene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF).

Reporting in the Aug. 12 issue of Cancer Cell, the scientists say they have uncovered new origins for these tumors from early stem cells as well as more mature cells. Previously, scientists had assumed the tumors might only come from a single source: more mature cells which become neurons and do not have "stem" cell properties. The findings hint at potential new treatment approaches for medulloblastoma by targeting the origins of the tumors, and further suggest that not all patients' tumors may be born from the same cells.

"We now have a better idea of where these brain tumors come from and their relationship to normal stem cells in the brain," said Keith Ligon, MD, PhD, co-senior author of the report and an investigator at the Center for Molecular Oncologic Pathology at Dana-Farber and the Brigham and Women's Hospital in Boston.

Co-senior author, David Rowitch, MD, PhD, currently a professor of pediatrics and neurosurgery at UCSF and a Howard Hughes Medical Institute investigator, commented that mouse experiments shed light on how normal stem cells -- cells with the power to create all types of cells in the brain -- can be transformed into tumors. The transformation occurs when a cell-signaling pathway known as Sonic hedgehog (named for a cartoon character) is reactivated by a chance mutation.

Sonic hedgehog plays an important role during the embryonic development of the brain, but normally shuts down when it's no longer needed. When turned on again by a mutation, the signals can trigger cell processes leading to tumors -- not just in the brain, but in other organs as well.

Medulloblastomas, usually diagnosed in child
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. One-Fifth of British Childhood Cancer Survivors Smoke
2. String probes for devastating childhood digestive disease
3. 1/5 of British adult survivors of childhood cancer smoke despite hazards
4. YMCA Calls on Senate to Fund Community-Based Solutions to Address Childhood Obesity Crisis
5. St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease
6. From Jet Engines to Search Engines, ORBIS-FedEx-Indiana University Join Forces to Fight Unnecessary Childhood Blindness
7. Aggressive treatment of childhood eczema could help prevent asthma, says new study
8. Topical oral syrup prevents early childhood caries
9. Stress during childhood increases the risk of allergies
10. U of M sets course for cure of fatal childhood skin disease
11. New Program/Website Targets Jewish Children, Teens, and Adults Suffering from the Impact of Childhood Maltreatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... In the United States alone, an ... treatment for an illicit drug or alcohol ... Mental Health Services Administration’s Survey on Drug Use and ... are harrowing stories of men and women whose lives ... David H. Kerr , founder and retired president of ...
(Date:4/25/2015)... New York, NY (PRWEB) April 25, 2015 ... systems, technology and data for the enterprise relying on their ... and running smoothly. But according to an article ... CIOs can many times actually be doing a disservice to ... the i’s are dotted and t’s are crossed when it ...
(Date:4/25/2015)... Gardant Management Solutions will lead ... operations, and sales and marketing at the LeadingAge ... be held from April 29 through May 1 ... largest eldercare association in Illinois. The statewide association ... adults, including senior housing, assisted living and supportive ...
(Date:4/25/2015)... Sports controversies continue to revolve around issues of abuse and violence. ... the Miami Dolphins and Richie Incognito, or off the field and ... abuse case. In a recent episode of SCI TV , ... locker room culture on teams. He examines what worked for the ... improve the locker room as a work place. , Steele ...
(Date:4/24/2015)... 24, 2015 Bird B Gone, the leader ... now offers a complete line of bird control solutions to ... , New Flu Strains Threaten Pacific, Central and Mississippi Farms ... , a number of highly pathogenic avian flus in ... is often spread when wild birds enter poultry farms. The ...
Breaking Medicine News(10 mins):Health News:New Book Features Powerful Stories of People Who Overcame Addiction 2Health News:New Book Features Powerful Stories of People Who Overcame Addiction 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 2Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 3Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 4Health News:An Outsider’s Perspective on Cyber Security Can Only Benefit CIOs 5Health News:Gardant Management Solutions Staff Shares Operational Expertise 2Health News:David Steele Discusses Locker Room Culture on SCI TV 2Health News:David Steele Discusses Locker Room Culture on SCI TV 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 4
... back, the 2008 Compensation Data results show benefits have seen little change ... ... October 29, 2008 -- General Motors has made headlines with plans to ... Retirees are also slated to loose health insurance coverage when they reach ...
... commercial with Jenny,Craig celebrity client, Valerie Bertinelli, ... pleased to,announce the three grand finalists of their ... Elaina Faustino and,Sara Hennessy are the three women ... TV commercial with Jenny Craig star client, Valerie ...
... (Nasdaq: WHRTD ) --,World Heart Corporation (WorldHeart or ... filing of articles of amendment with Industry,Canada under the ... Capital Market on a post-consolidation basis on October 28,2008. ... split at a Special Meeting of Shareholders held on ...
... Quarter Net Sales of $3.9 Million; 29% Increase ... - Second Fiscal Quarter U.S. Sales of $2.2 Million; 83% Increase ... Year-Over-Year -, - Multicenter Clinical Study Launched to Expand Reimbursement, Support ... Marketing - - Conference Call to be Held ...
... Oct. 29 Heralding the newest innovation,in home skin ... of light therapy, has announced the retail launch of ... Quasars are widely,acclaimed as the first professional devices made ... the Baby Quasar delivers exceptional,skin care results and can ...
... cloud symptoms, study says , , WEDNESDAY, Oct. 29 (HealthDay News) ... in people if they have other medical conditions, a new ... high cholesterol appeared to mask early MS symptoms and lead ... in the Oct. 29 online issue of Neurology . ...
Cached Medicine News:Health News:Cuts at General Motors Bring Benefit Trends to the Forefront 2Health News:Cuts at General Motors Bring Benefit Trends to the Forefront 3Health News:Jenny Craig Announces Finalists for the 2008 Ideal Size Contest 2Health News:WorldHeart Announces Effectiveness of Reverse Stock Split 2Health News:WorldHeart Announces Effectiveness of Reverse Stock Split 3Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 2Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 3Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 4Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 5Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 6Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 7Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 8Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 9Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 10Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 11Health News:Uroplasty Reports Continued Progress During Second Quarter of Fiscal 2009 12Health News:Baby Quasar Lights Up Dillard's for the Retail Holiday Season 2Health News:Other Health Problems Can Delay MS Diagnosis 2
(Date:4/24/2015)... , April 24, 2015 /CNW/ - T-Bird Pharma ... focused on developing premium quality medical marijuana products and ... Marihuana for Medical Purposes Regulations ( Canada ... with certain of its shareholders, has closed the transaction ... ("Medna").  Medna has acquired (the "Escrow Transfer") a total ...
(Date:4/24/2015)... -- Elekta has CE marked the latest version (v5.10) of ... European clinics to deliver a sophisticated radiation therapy planning ... planning, IMRT, VMAT and stereotactic planning – all in ... ® v5.10 provides significant planning and ... 3D planning as well as the addition of MRI ...
(Date:4/23/2015)... CHICAGO, Ill. , April 24, 2015  AbbVie ... Food and Drug Administration (FDA) has accepted its New ... company,s, all-oral, interferon-free, two direct-acting antiviral treatment of ombitasvir, ... for the treatment of adults with chronic genotype 4 ... regimen is the first all-oral, interferon-free therapy being evaluated ...
Breaking Medicine Technology:T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 3Elekta CE marks for Monaco v5.10 treatment planning system 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 3U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 4U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 5U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 6U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 7
... Knopp Neurosciences Inc. ("Knopp"),announced that the U.S. ... Development has granted orphan drug designation to ... (ALS). (Logo: http://www.newscom.com/cgi-bin/prnh/20070924/KNOPPLOGO ) ... studies to evaluate the safety,tolerability and pharmacokinetics ...
... on stringent endpoint of clinical ... PHILADELPHIA, Oct. 15 An analysis of data to,be ... Scientific Meeting found that Asacol, dosed at 2.4 g/day, ... active,ulcerative colitis (UC). The analysis was based on data ...
Cached Medicine Technology:Knopp Neurosciences Receives Orphan Designation for KNS-760704 for Treatment of ALS 2New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients 2New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients 3New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients 4
... Caliper provide an automated alternative to Kuderna-Danish, Rotary, Vacuum-Style and Nitrogen Blow-Down Evaporators. For over ten years ... ... ... ...
... The UltraVac manifold is designed ... The manifold holds one deep ... Samples and buffers are drawn through ... collection plates or microplates. The ...
QIAvac 6S provides all manifold components for processing QIAGEN 8-well strips....
Holder for QIAGEN 96-well plates, for use with QIAvac 96;...
Medicine Products: