Navigation Links
Childhood adversity increases risk for depression and chronic inflammation
Date:7/3/2012

Philadelphia, PA, July 3, 2012 When a person injures their knee, it becomes inflamed. When a person has a cold, their throat becomes inflamed. This type of inflammation is the body's natural and protective response to injury.

Interestingly, there is growing evidence that a similar process happens when a person experiences psychological trauma. Unfortunately, this type of inflammation can be destructive.

Previous studies have linked depression and inflammation, particularly in individuals who have experienced early childhood adversity, but overall, findings have been inconsistent. Researchers Gregory Miller and Steve Cole designed a longitudinal study in an effort to resolve these discrepancies, and their findings are now published in a study in Biological Psychiatry.

They recruited a large group of female adolescents who were healthy, but at high risk for experiencing depression. The volunteers were then followed for 2 years, undergoing interviews and giving blood samples to measure their levels of C-reactive protein and interleukin-6, two types of inflammatory markers. Their exposure to childhood adversity was also assessed.

The researchers found that when individuals who suffered from early childhood adversity became depressed, their depression was accompanied by an inflammatory response. In addition, among subjects with previous adversity, high levels of interleukin-6 forecasted risk of depression six months later. In subjects without childhood adversity, there was no such coupling of depression and inflammation.

Dr. Miller commented on their findings: "What's important about this study is that it identifies a group of people who are prone to have depression and inflammation at the same time. That group of people experienced major stress in childhood, often related to poverty, having a parent with a severe illness, or lasting separation from family. As a result, these individuals may experience depressions that are especially difficult to treat."

Another important aspect to their findings is that the inflammatory response among the high-adversity individuals was still detectable six months later, even if their depression had abated, meaning that the inflammation is chronic rather than acute. "Because chronic inflammation is involved in other health problems, like diabetes and heart disease, it also means they have greater-than-average risk for these problems. They, along with their doctors, should keep an eye out for those problems," added Dr. Miller.

"This study provides important additional support for the notion that inflammation is an important and often under-appreciated factor that compromises resilience after major life stresses. It provides evidence that these inflammatory states persist for long periods of time and have important functional correlates," said Dr. John Krystal, Editor of Biological Psychiatry.

Further research is necessary, to extend the findings beyond female adolescents and particularly in individuals with more severe, long-term depression. However, findings such as these may eventually help doctors and clinicians better manage depression and medical illness for particularly vulnerable patients.


'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Related medicine news :

1. Researchers find abuse during childhood may contribute to obesity in adulthood
2. Prenatal exposure to common household chemical increases risk for childhood eczema, study says
3. Celebrex-derived drug targets common childhood bone tumor
4. Gene sequencing project identifies potential drug targets in common childhood brain tumor
5. Presidential candidates should address childhood obesity and bullying, poll says
6. Childhood obesity linked to math performance, MU researcher says
7. Holy glycosylation! New bat signal flags distressed cells in childhood genetic diseases
8. Mayo Clinic, youth mental health experts, publish new guidelines to treat childhood aggression
9. Emotional Woes May Last for Childhood Cancer Survivors
10. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
11. Viral infections in infancy are not associated with wheezing symptoms in later childhood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... According to the Webster’s dictionary, a hippie ... chemical-laden beauty products, one company is going against the norm with a line of ... rising star in the green space is proud to announce its latest retail partnership ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... HealthPostures, ergonomics ... Angle chair , furniture that may support women during pregnancy. Potential benefits of using ... feet, improved rest and comfort and healthier levels of sitting and standing. , Need ...
(Date:5/25/2016)... ... ... The United States Food and Drug Administration (FDA) has now cleared Capillus® ... date, the company is the first and only manufacturer of low level laser therapy ... alopecia. , “This new level of clearance substantiates what many physicians have experienced ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... a Managing Partner at HealthScape Advisors. “Brad brings significant experience advising healthcare provider ... delivery system accelerates with the implementation of MACRA, we believe that continuing to ...
(Date:5/25/2016)... , ... May 25, 2016 , ... Furthering its position ... athletics, The National Center for Drug Free Sport (Drug Free Sport®) is excited to ... conference, to be held July 12 – 13 in Kansas City, MO, will gather ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... -- According to a new market research ... by Therapeutic Area (Oncology, Cosmeceutical/Plastic Surgery), by Application (Drug ... Hospitals/ Clinics) - Forecast to 2021", published by MarketsandMarkets, ... the forecast period of 2016 to 2021. This market ... from USD 117.3 Million in 2016, at a CAGR ...
(Date:5/25/2016)... 25, 2016  Zymo Research Corp. announced today ... reference materials that help researchers obtain the most ... analyses. The rapid growth of the study of ... have standard methods to improve the reproducibility and ... exist at every step of the measurement process ...
(Date:5/25/2016)... As illustrated by the Spring ... the numbers and momentum of cannabis in the US ... billions, more research and development push the sector forward. ... Legal Marijuana Markets Report  from from ArcView Market Research ... the increase in sector is attributed to adult use ...
Breaking Medicine Technology: