Navigation Links
Childhood Urinary Tract Infection May Bring Lasting Harm to Kidneys
Date:8/5/2014

By
HealthDay Reporter

TUESDAY, Aug. 5, 2014 (HealthDay News) -- Urinary tract infections are the most common serious bacterial infections in young children, and almost one of every eight kids who gets one will end up with scarring on the kidneys and an increased risk of kidney failure later in life.

Identifying those kids early is critical, and researchers now report that a combination of three factors -- high fever, detection of kidney abnormalities via ultrasound and identification of the type of bacteria involved -- spots such patients as accurately as a very unpleasant catheter-based test does.

"We found that you more or less can predict the children who are at higher risk by looking at three different things when they come in," said study author Dr. Nader Shaikh, an assistant professor at the University of Pittsburgh and a pediatrician at the Children's Hospital of Pittsburgh.

In the past, doctors used a combination catheter/X-ray to detect children at greater risk for kidney scarring.

The test required using a catheter to fill a child's bladder with a special dye. Doctors then asked the child to urinate while being X-rayed, so they could see whether urine flow indicated a kidney problem.

Doctors used the X-ray test often in the 1960s and 1970s, but in recent years they have been moving away from it, said Dr. Kenneth Roberts, a pediatrician in Greensboro, N.C., who wrote an editorial accompanying the new study.

"It's very uncomfortable, very distressing and entails a good amount of radiation," Roberts said. "It is not only not worth putting all children through that procedure, but with this study we now have information that shows it's simply not justified."

To see whether there is a better option for finding kids at greater risk of kidney scarring, Shaikh and his colleagues reviewed existing data from previous studies involving 1,280 children aged 18 and younger.

About 15 percent of these children suffered kidney scarring from a urinary tract infection. The researchers found that three factors were strongly associated with scarring:

  • Fever of at least 102 degrees.
  • Infection with a bacteria other than E. coli.
  • Ultrasound readings that detected an abnormality in the kidney.

A model based on these factors predicted nearly 45 percent of children who ended up developing kidney scars, a rate only 3 percent to 5 percent less effective than models involving blood tests or the catheter/X-ray examination, the researchers reported.

The findings were published online Aug. 4 in the journal JAMA Pediatrics.

The test's real power comes in its ability to rule out children at risk, Shaikh noted.

"The prediction is not perfect," he said. "For more or less, we can say these 80 percent of kids aren't going to scar, we don't have to worry about them."

Doctors can step up observation of kids at greater risk for kidney scarring. "The main focus should be to prevent subsequent infections for those children," Shaikh said. "Every time you get a [urinary tract infection], you get a chance of scarring again."

Roberts agreed.

"Now that we know the groups at greatest risk, maybe we can come up with methods for decreasing inflammation during this infection and possibly preventing scars," he said. "We can back off the things we're doing that are distressing to children, and think about novel ways to preserve the kidneys of these children."

More information

Visit the U.S. National Institute of Diabetes and Digestive and Kidney Diseases for more on urinary tract infections in children.

SOURCES: Nader Shaikh, M.D., M.P.H., assistant professor, University of Pittsburgh, and pediatrician, Children's Hospital of Pittsburgh; Kenneth Roberts, M.D., pediatrician, Greensboro, N.C.; Aug. 4, 2014, JAMA Pediatrics, online


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New study identifies promising, achievable solutions to Nigerias childhood mortality crisis
2. Symptomatic behaviour in childhood strongly predicts psychiatric treatment as a young adult
3. Study identifies potential treatment for lethal childhood leukemia
4. Childhood Obesity May Raise Odds of Adult Liver Cancer
5. IADR/AADR publish studies on severe early childhood caries - proposes new classification
6. Could the Childhood Obesity Epidemic Be Ebbing?
7. Better health in adulthood starts with early prevention in childhood
8. Environment key to preventing childhood disabilities
9. Treating childhood obesity: A family affair
10. Pneumonia and preterm birth complications are the leading causes of childhood death
11. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Childhood Urinary Tract Infection May Bring Lasting Harm to Kidneys 
(Date:2/9/2016)... FL (PRWEB) , ... February 09, 2016 , ... ... innovative specialty pharmacies, announces today the continuation of the ‘Pay It Forward’ program ... each prescription referral received at our specialty pharmacy. , “Since our Pay ...
(Date:2/9/2016)... ... 2016 , ... On January 12, 2016 Paul McElwee, a CroppMetcalfe HVAC technician, ... furnace not producing any heat. Shortly after entering the home, Paul was able to ... dangerous levels of carbon monoxide into the home, at 2,000 parts per million in ...
(Date:2/9/2016)... ... February 09, 2016 , ... The Bon-Ton ... and Younkers department stores, announced it has raised $176,000 to benefit the Breast ... Comprehensive Cancer Center at the University of Iowa, The Lynn Sage Cancer Research ...
(Date:2/9/2016)... ... February 09, 2016 , ... ZipHearing.com ... access to affordable hearing aids , increase industry transparency, and promote awareness ... United States. , “For the average consumer, the hearing aid industry is esoteric ...
(Date:2/9/2016)... , ... February 09, 2016 , ... ... products, announced today the introduction of the newly designed, innovative shoulder wrap. ... better cold therapy coverage for the injured arm and shoulder to promote faster ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016   HighPoint Solutions today ... (NRG),s pharmacovigilance technology services division.  NRG is a ... an Oracle Argus Specialized partner, providing drug safety ... companies. --> --> ... sciences capabilities and provides a global scale and ...
(Date:2/8/2016)... BOSTON , Feb. 8, 2016   Intarcia ... John Yee , MD, MPH, into the newly created ... Safety and Operations. Dr. Yee has two decades of ... companies, and at a major academic medical center. Most ... Affairs, US Diabetes, and VP, US Head Medical Officer ...
(Date:2/8/2016)... Calif. , Feb. 8, 2016 Lonza, a ... Sciences Inc., a biopharmaceutical company designing and developing novel ... agreements for the clinical supply of Kodiak,s therapeutic candidates. ... sites, including Slough (UK), Visp (CH) and Nansha (CN). ... Retinal diseases, such as age-related macular degeneration (AMD), cause ...
Breaking Medicine Technology: