Navigation Links
Childhood Leukemia Subtype Resists Treatment

Those with rare gene have disease relapse often within 5 years of apparent remission

FRIDAY, Jan. 9 (HealthDay News) -- Researchers say they have identified a rare subtype of a childhood leukemia that does not respond well to treatment.

Those with the subtype of acute lymphoblastic leukemia (ALL) have a BCR-ABL1 fusion gene. In the Dutch and German genetic analysis of children recently diagnosed with ALL, those with this gene tended to have relapse of the disease, often within five years of initially appearing disease-free.

The findings were published online Jan. 9 and will appear in the February print issue of The Lancet Oncology.

Although success rates for treating and curing many childhood leukemias are high, some with certain subtypes of ALL tend to fair poorly. About a quarter have genetically unclassified strains of the disease in which relapse is frequent.

Being able to pinpoint this disease subtype could help guide treatment decisions and improve outcomes.

"These data suggest that the BCR-ABL1-like [subtype] constitutes a large subgroup with poor prognosis that is unrecognized with current diagnostic markers," study leader Monique Den Boer, of University Medical Centre in Rotterdam, said in a news release issued by the journal. "These patients should receive more intensive therapy with available drugs or with new, more targeted drugs for which the biology of the BCR-ABL1-like subtype needs further study. Improved treatment of this high-risk leukemia will have a great effect on the overall cure rate of childhood ALL."

More information

The Nemours Foundation has more about childhood leukemia.

-- Kevin McKeever

SOURCE: The Lancet, news release, Jan. 8, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Nemours Center for Childhood Cancer Research Receives Over $1 Million in Grants for Cancer Research in 2008
2. Gene abnormality found to predict childhood leukemia relapse
3. Childhood Trauma Tied to Chronic Fatigue Syndrome
4. New insight into aggressive childhood cancer
5. Family rejection of LGB children linked to poor health in early childhood
6. Childhood anxiety disorders can and should be treated, according to UT Southwestern national expert
7. Yeast mimics severity of mutations leading to fatal childhood illness
8. UCSF receives $24.4 million to fight early childhood cavities
9. Childhood Obesity May Cause Thyroid Problems
10. Antacid Medication in Pregnancy May Increase Childhood Asthma
11. More Than $2.4 Million Raised by National Halloween Promotion Partners to Help St. Jude Fight Childhood Cancer
Post Your Comments:
Related Image:
Childhood Leukemia Subtype Resists Treatment
(Date:11/24/2015)... ... ... Young patients with a wide variety of dental needs can now receive ... who are pediatric dentists in Tucson, AZ . Unlike traditional treatment options that ... minimal discomfort and bleeding to the patient during treatment and the following recovery period. ...
(Date:11/24/2015)... ... ... DMG Productions announced that they will feature Aphria, Inc., in an upcoming episode ... and show times TBA. , Aphria, Inc., is a publicly traded company incorporated under ... medical marijuana pursuant to the Marijuana for Medical Purposes Regulations (the “MMPR”). , Aphria ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... Bolier Reactor System. Brillouin is the developer of renewable energy technologies capable of ... nuclear reactions (“LENR”), announced today that its WET™ and HHT™ Boiler System reactor ...
(Date:11/24/2015)... ... November 24, 2015 , ... American Family Care (AFC), the nation’s ... a holiday pop-up clinic located in Metro Atlanta’s North Point Mall. The clinic is ... different way. The location is scheduled to operate through Dec. 24. , Holiday Pop-Up ...
(Date:11/24/2015)... ... November 24, 2015 , ... Abington Hospital – Jefferson Health ... Quality® Bariatric Surgery Facility for treating individuals living with morbid or extreme obesity. ... available to its members to help them make informed decisions about their healthcare ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... WuXi PharmaTech (Cayman) Inc. ("WuXi" or the ... capability and technology platform company serving the pharmaceutical, biotechnology, ... China and the United States ... meeting of shareholders held today, the Company,s shareholders voted ... the previously announced agreement and plan of merger (the ...
(Date:11/24/2015)... , Nov. 24, 2015  In the pharmaceutical ... in an effort to quickly uncover new insights, tactics ... --> --> However, organizations ... market research project and ensure that all rules and ... industry standards. Another major barrier to efficiently launching market ...
(Date:11/24/2015)... Nov. 24, 2015  DILON Diagnostics and GE Healthcare ... agreement for DILON to distribute GE,s Discovery NM750b Molecular ... signing of this distribution agreement will provide Dilon,s experienced ... Imaging system and is considered an initial step in ... solutions for clinicians and their patients. ...
Breaking Medicine Technology: