Navigation Links
Childhood Leukemia Subtype Resists Treatment
Date:1/9/2009

Those with rare gene have disease relapse often within 5 years of apparent remission

FRIDAY, Jan. 9 (HealthDay News) -- Researchers say they have identified a rare subtype of a childhood leukemia that does not respond well to treatment.

Those with the subtype of acute lymphoblastic leukemia (ALL) have a BCR-ABL1 fusion gene. In the Dutch and German genetic analysis of children recently diagnosed with ALL, those with this gene tended to have relapse of the disease, often within five years of initially appearing disease-free.

The findings were published online Jan. 9 and will appear in the February print issue of The Lancet Oncology.

Although success rates for treating and curing many childhood leukemias are high, some with certain subtypes of ALL tend to fair poorly. About a quarter have genetically unclassified strains of the disease in which relapse is frequent.

Being able to pinpoint this disease subtype could help guide treatment decisions and improve outcomes.

"These data suggest that the BCR-ABL1-like [subtype] constitutes a large subgroup with poor prognosis that is unrecognized with current diagnostic markers," study leader Monique Den Boer, of University Medical Centre in Rotterdam, said in a news release issued by the journal. "These patients should receive more intensive therapy with available drugs or with new, more targeted drugs for which the biology of the BCR-ABL1-like subtype needs further study. Improved treatment of this high-risk leukemia will have a great effect on the overall cure rate of childhood ALL."

More information

The Nemours Foundation has more about childhood leukemia.



-- Kevin McKeever



SOURCE: The Lancet, news release, Jan. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Nemours Center for Childhood Cancer Research Receives Over $1 Million in Grants for Cancer Research in 2008
2. Gene abnormality found to predict childhood leukemia relapse
3. Childhood Trauma Tied to Chronic Fatigue Syndrome
4. New insight into aggressive childhood cancer
5. Family rejection of LGB children linked to poor health in early childhood
6. Childhood anxiety disorders can and should be treated, according to UT Southwestern national expert
7. Yeast mimics severity of mutations leading to fatal childhood illness
8. UCSF receives $24.4 million to fight early childhood cavities
9. Childhood Obesity May Cause Thyroid Problems
10. Antacid Medication in Pregnancy May Increase Childhood Asthma
11. More Than $2.4 Million Raised by National Halloween Promotion Partners to Help St. Jude Fight Childhood Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Childhood Leukemia Subtype Resists Treatment
(Date:5/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... as the Medical Director of its new DeSoto facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:5/25/2016)... ... May 25, 2016 , ... American Spine ... minimally invasive, endoscopic spine surgeries in the Montgomery County, Howard County and Washington, ... the Germantown office of American Spine every Monday. He will also perform surgeries ...
(Date:5/24/2016)... ... May 24, 2016 , ... BTC Media, ... blockchain event, Distributed: Health, to be held in Nashville, Tennessee on September 7, ... A 24-hour Hackathon preceding the event will host teams from around the world, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Fire Door Solutions, ... one resource, from start to finish, for Life Safety compliance. These expanded ... surveys requested by the Joint Commission, and fire stopping reviews, inspections, and repairs. ...
(Date:5/24/2016)... , ... May 24, 2016 , ... Jericho Project has ... this role she will be responsible for fundraising and communications for the nationally-acclaimed nonprofit, ... impact of Jericho Project working to end homelessness at its roots. , “LaToya ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Niederländische Chirurgen haben eine ... Ärzten erlaubt, ihre Expertise weltweit zu teilen und ... Streaming mit einer Instant-Messaging-Funktion und der Möglichkeit, in ... Europa, Afrika, Asien und den USA ... registriert. Information und Weiterbildung   ...
(Date:5/24/2016)... ARANZ Medical  Ltd a specialist ... has been named the Coretex Hi-Tech Emerging Company of the ... Dr Bruce Davey , CEO of ARANZ Medical says, ... good to be recognised for the work we are doing ... in 35 countries around the world from Sub-Saharan Africa through ...
(Date:5/24/2016)... 2016 Los innovadores de ... mundo, introduce catéteres para la intervención de extremidades ... compañía global especializada en el suministro de soluciones ... cartera incluyendo productos para tratar la enfermedad arterial ... son los dispositivos de primera entrada de la ...
Breaking Medicine Technology: