Navigation Links
Childhood Leukemia Subtype Resists Treatment
Date:1/9/2009

Those with rare gene have disease relapse often within 5 years of apparent remission

FRIDAY, Jan. 9 (HealthDay News) -- Researchers say they have identified a rare subtype of a childhood leukemia that does not respond well to treatment.

Those with the subtype of acute lymphoblastic leukemia (ALL) have a BCR-ABL1 fusion gene. In the Dutch and German genetic analysis of children recently diagnosed with ALL, those with this gene tended to have relapse of the disease, often within five years of initially appearing disease-free.

The findings were published online Jan. 9 and will appear in the February print issue of The Lancet Oncology.

Although success rates for treating and curing many childhood leukemias are high, some with certain subtypes of ALL tend to fair poorly. About a quarter have genetically unclassified strains of the disease in which relapse is frequent.

Being able to pinpoint this disease subtype could help guide treatment decisions and improve outcomes.

"These data suggest that the BCR-ABL1-like [subtype] constitutes a large subgroup with poor prognosis that is unrecognized with current diagnostic markers," study leader Monique Den Boer, of University Medical Centre in Rotterdam, said in a news release issued by the journal. "These patients should receive more intensive therapy with available drugs or with new, more targeted drugs for which the biology of the BCR-ABL1-like subtype needs further study. Improved treatment of this high-risk leukemia will have a great effect on the overall cure rate of childhood ALL."

More information

The Nemours Foundation has more about childhood leukemia.



-- Kevin McKeever



SOURCE: The Lancet, news release, Jan. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Nemours Center for Childhood Cancer Research Receives Over $1 Million in Grants for Cancer Research in 2008
2. Gene abnormality found to predict childhood leukemia relapse
3. Childhood Trauma Tied to Chronic Fatigue Syndrome
4. New insight into aggressive childhood cancer
5. Family rejection of LGB children linked to poor health in early childhood
6. Childhood anxiety disorders can and should be treated, according to UT Southwestern national expert
7. Yeast mimics severity of mutations leading to fatal childhood illness
8. UCSF receives $24.4 million to fight early childhood cavities
9. Childhood Obesity May Cause Thyroid Problems
10. Antacid Medication in Pregnancy May Increase Childhood Asthma
11. More Than $2.4 Million Raised by National Halloween Promotion Partners to Help St. Jude Fight Childhood Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Childhood Leukemia Subtype Resists Treatment
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
(Date:9/23/2017)... 2017 Janssen Biotech, Inc. (Janssen) announced today ... the U.S. Food and Drug Administration (FDA) for the ... the treatment of moderately to severely active rheumatoid arthritis ... are needed to further evaluate the safety of sirukumab ... "We are ...
Breaking Medicine Technology: