Navigation Links
Childhood Cancer Survivors Prone to Early Heart Trouble
Date:5/16/2008

Problems surface at younger age than in people who didn't have cancer as children, study finds

FRIDAY, May 16 (HealthDay News) -- Adults who had cancer as children or teens are more likely to experience cardiovascular disease, a new study found.

And the heart problems surface at a much earlier age than in people who did not suffer cancer as children.

Childhood cancer survivors "have approximately a five to 10 times increased risk of having heart disease compared to their healthy siblings," said study lead author Dr. Daniel A. Mulrooney, assistant professor of pediatrics at the Masonic Cancer Center of the University of Minnesota, Minneapolis.

Mulrooney was expected to present his findings Thursday night at the American Society of Clinical Oncology annual meeting, in Chicago.

There are an estimated 270,000 survivors of childhood cancer in the United States, and 11 million cancer survivors total.

While the cancer survivors in the new study ranged in age from 8 to 51, the average age of those with heart problems was only 27.5 years.

"We're talking about a very young population that's having very significant cardiac disease and is likely not being monitored appropriately," Mulrooney added. "It is very important that they be followed and that risk factors and cardiovascular monitoring that we would think of in an older population be implemented in a younger population."

The findings aren't entirely surprising. Previous research, much of it with the same group of survivors, has shown an increased risk of cardiovascular disease in survivors of childhood and adolescent cancer.

The new analysis, the longest follow-up to date, provides updated information on 14,358 five-year survivors of childhood cancer. All the participants were diagnosed with one of eight cancers (including leukemia, lymphoma and brain malignancies) at 21 years of age or younger, between 1970 and 1986.

The study participants provided information on their own heart health, which was then compared to a control group of 3,899 healthy siblings.

Compared to the healthy brothers and sisters, the survivors of childhood cancer were almost six times more likely to report congestive heart failure; about five times more likely to report having had a heart attack or valvular heart disease; more than six times likelier to have pericardial disease (the pericardium is the sac that surrounds the heart); more than eight times as likely to have had an angiography; and 10 times more likely to have atherosclerosis, or hardening of the arteries.

Exposure to the chemotherapy drug anthracycline increased the risk of congestive heart failure about fourfold, roughly doubled the risk of pericardial and valvular disease, and almost tripled the odds of having had an angiography, the study found.

Radiation treatment to the heart doubled the risk of congestive heart failure, heart attack and pericardial disease, almost tripled the risk of valvular disease, and increased the risk of atherosclerosis by a factor of more than five, according to the study.

Dr. Karen Burns is clinical director of the ATP5+ Clinic for Childhood Cancer Survivors at Cincinnati Children's Hospital. She said most of the heart problems seen in survivors of childhood cancer come from the class of chemotherapy drugs called anthrocyclines, which cause problems with cardiac muscle, and from radiation, if the radiation field included the heart.

Although monitoring for heart disease in childhood cancer survivors is already in place in many specialized facilities, Burns said she hoped that, "if this study is available to the general public, it will encourage people who are survivors to get closer follow-up."

Mulrooney added: "We see this in our long-term follow-up clinic. We identify patients who are at risk based on this analysis and may do an echocardiogram or a lipid panel, things we might not typically do in a 20-year-old. There are tools out there, and getting this knowledge out there as well would be helpful so primary-care physicians will be more aware, oncologists and cardiologists will be aware, and patients as well."

More information

To learn more, visit the National Childhood Cancer Foundation.



SOURCES: Daniel A. Mulrooney, M.D., assistant professor of pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis; Karen Burns, M.D., clinical director of the ATP5+ Clinic for Childhood Cancer Survivors, Cincinnati Children's Hospital; May 15, 2008, presentation, American Society of Clinical Oncology annual meeting, Chicago


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genetic predisposition increases childhood asthma risk
2. Treating diabetes during pregnancy can break link to childhood obesity
3. Childhood asthma still inappropriately treated in the UK
4. Screening Proposed for Childhood Cholesterol Levels
5. Success of Shape-Up Somerville Childhood Obesity Intervention to be Presented at the Friedman School Symposium at Tufts, October 29-31, 2007 - Boston
6. Success of Shape Up Somerville childhood obesity intervention to be presented
7. Childhood vaccination may protect adult eyes
8. Childhood Obesity Epidemic a Long-Term Challenge
9. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
10. Antibiotics Not Always Best Bet for Battling Childhood Ear Infections
11. Childhood TV viewing a risk for behavior problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... Waltham, MA (PRWEB) , ... April 29, 2016 ... ... 1st, the Two Ten Footwear Foundation, the national charitable foundation serving the footwear ... activities. With 8,000 volunteers representing more than 130 companies across 23 states during ...
(Date:4/29/2016)... Fl (PRWEB) , ... April 29, 2016 , ... ... recently notified by the Accreditation Council for Graduate Medical Education (ACGME) that it ... , This is the first accreditation of three residency programs that Memorial is ...
(Date:4/29/2016)... Sedona, Arizona (PRWEB) , ... April 29, 2016 ... ... Shamanic Healing and Spiritual Awakening , announces the addition Onnit brand Alpha BRAIN ... , The addition of Onnit brain and mood optimization products to the store ...
(Date:4/29/2016)... ... April 29, 2016 , ... Our bodies are bombarded ... to confront and deal with these stressors is to adopt a more healthful diet, ... for you. Risa Groux, a certified Holistic Nutritionist and the creator of the Newport ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... On Tuesday, ... hospitals across the Southeast, celebrated the signature of Gov. Nathan Deal on SB 258, ... Geoff Duncan (R - Cumming), offers a 70% tax credit to individuals and corporations ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016 Global  urinalysis ... billion by 2022, according to a new report ... (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... efficiency and accuracy delivered by the new generation ... novel urinalysis instruments and consumables. For instance, the ...
(Date:4/27/2016)... , April 27, 2016 ... announced the launch of a Phase 2 clinical study ... hearing in patients undergoing cochlear implantation (CI) surgery. This ... patients in Germany and ... the middle ear at the time of surgery. "Despite ...
(Date:4/26/2016)... 2016 Hill-Rom Holdings, Inc. (NYSE: HRC ... the Deutsche Bank 41 st Annual Health Care Conference ... You are invited to listen to the live discussion ... it directly at http://edge.media-server.com/m/p/mr4uxgas . A recorded replay of ... the live event and accessible at the links above until ...
Breaking Medicine Technology: