Research by board-certified reproductive endocrinologist Richard Sherbahn, MD, at the Advanced Fertility Center of Chicago reveals that the age of a woman receiving donated eggs significantly affects her chances of implantation and successful pregnancy.
Gurnee, Ill. (PRWEB) June 4, 2009 -- Infertility specialist Richard Sherbahn, MD, recently presented research to the American Society for Reproductive Medicine regarding the effect of a woman recipient's age on the outcome of egg donation.
Dr. Sherbahn studied 452 egg donation cycles using donors under age 31 between 1998 and 2007. He separated the recipients into two groups according to age, with women under 45 in one group and women ages 45-50 in the other group.
The study compared the two groups' recipient and donor ages, as well as the number of embryos transferred and the rates of implantation, clinical pregnancy, miscarriage and live birth.
Dr. Sherbahn found no differences between the two groups' average donor ages or the average number of embryos transferred. However, the study showed that recipients ages 45-50 had lower rates of implantation, clinical pregnancy and live birth, and a higher rate of miscarriage than women under age 45.
"The differences between the recipient age groups' rates of implantation and miscarriage were statistically significant, although the differences in their rates of clinical pregnancy and live birth were not," says Dr. Sherbahn.
"There is a significant reduction in implantation rates -- and a notable increase in miscarriage rates -- in egg donation recipients ages 45-50," Dr. Sherbahn concludes.
"A woman's uterine receptivity might decline with advancing age due to unknown biochemical and/or molecular changes in the uterine lining," he says. "This decline could also be the result of a higher incidence of other pathological conditions in the uterus, such as fibroid tumors, polyps, or scarring and adhesions known as Asherman's syndrome."
"High blood pressure and other systemic disorders are more common in older women; these could also contribute to the reduced potential for implantation and a successful pregnancy," Dr. Sherbahn explains.
For some women, in-vitro fertilization (IVF) with donated eggs has succeeded after multiple IVF cycles using their own eggs have failed. Forty-year-old Gail and her husband are now expecting twins, thanks to IVF with donor eggs.
"This has been a seven-year journey for me and my husband," Gail explains. "I got married at 33, so we attempted to start a family right away. Within a year, I got pregnant naturally and miscarried. Then I got pregnant immediately again and miscarried a second time."
Gail and her husband sought fertility treatment at another clinic, undergoing six intra-uterine inseminations, also called artificial insemination, before trying IVF. "The first IVF we did worked -- I got pregnant again -- and miscarried," Gail recalls. "It was devastating." Three more IVF attempts at that clinic were unsuccessful, including one with donor eggs.
Then Gail and her husband came to the Advanced Fertility Center of Chicago. "We chose egg donation because that was going to give us the best chance of success," she explains. "We went through one IVF cycle. They implanted two embryos -- and I'm 11 weeks pregnant! I've never made it this far before. We're thrilled! And the best news is that I'm pregnant with twins. It's the biggest blessing that we could ever have imagined."
"Because we have high success rates, flexible pricing options (including money-back guarantees) and immediate availability of numerous egg donors, we see a lot of interest in our donor program from local couples -- as well as from people in other states and countries," says Dr. Sherbahn.
The Advanced Fertility Center of Chicago, with offices in Gurnee and Crystal Lake, Ill., offers advanced reproductive technology services such as in-vitro fertilization (IVF), intracytoplasmic sperm injection and egg donation.
The Center specializes in individualized care, and has IVF success rates and egg donation success rates above the national averages. Advanced Fertility has egg donors available immediately, with no third-party egg donor agency needed.
The Center's web site, www.advancedfertility.com, offers more than 200 articles on fertility issues and IVF. To schedule an appointment at the Gurnee office, call 847.662.1818. For an appointment at the Crystal Lake office, call 815.356.1818.
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