Navigation Links
Chewing Khat Raises Heart Disease, Death Risk: Study
Date:12/13/2011

By Alan Mozes
HealthDay Reporter

TUESDAY, Dec. 13 (HealthDay News) -- Chewing the green leaves of the khat plant for its amphetamine-like effect appears to raise the risk for both stroke and death among heart patients, according to a large new study from the Middle East.

The finding, however, could have relevance far beyond that region, as emigration has increasingly brought khat-chewing to the shores of both Europe and North America.

Consumed by an estimated 10 to 20 million people worldwide, for centuries the naturally grown Catha edulis shrub has been widely available (and most popular) across East Africa and the southern Arabian Peninsula, where some people munch on khat in pursuit of a euphoric or aroused state of mind.

"We need to be careful about the risk of using 'herbs' and 'natural substances,' and khat is an example, although it is leaves, which appear 'harmless'," said study co-author Dr. Jassim Al Suwaidi, senior consultant cardiologist at Hamad General Hospital in Doha, Qatar.

"It has chemical constituents that are similar to harmful drugs," Suwaidi noted, "such as cocaine and amphetamine, and may cause heart attack as well as increase the risk of death and stroke from heart attack."

Suwaidi and his colleagues report their findings in the Dec. 12 issue of Circulation.

The principal active ingredients in khat are cathine and cathinone. According to the U.S. National Institute on Drug Abuse (NIDA), these chemicals are similar in structure to amphetamine and have similar (although weaker) stimulant effects.

The NIDA notes that the euphoria, elation, alertness and arousal from chewing khat typically last anywhere from 1.5 to three hours, but can endure for a full day. Blood pressure and heart rates may rise during that time, followed by the short-term onset of depression, irritability and sleep problems.

Long-term chewing of khat can lead to tooth decay and gastrointestinal problems, in addition to cardiovascular issues such as coronary artery spasm.

Because cathinone is a Schedule I narcotic under U.S. federal law, khat is illegal and as with drugs such as heroin or mescaline, cannot be used for medical or other purposes.

Although banned in Germany, France and the Netherlands, khat is currently legal in the United Kingdom.

Khat is legal and in widespread use throughout Yemen and Ethiopia, and is currently permitted for sale in Israel.

To explore how khat might boost health risks among individuals with a history of heart disease, between 2008 and 2009 the authors focused on roughly 7,400 men and women who were part of the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2) Study.

All were being treated for acute coronary syndrome in one of 65 hospitals across Saudi Arabia, Bahrain, Yemen, Qatar, United Arab Emirates and Oman.

Of these participants, about 20 percent were deemed to be regular khat chewers, almost all (96 percent) from Yemen. They more likely to be older and male (14 percent were women), but less likely to have heart health risk factors than non-Khat chewers.

While still being treated in hospital, khat heart patients had about double the death rate due to cardiovascular illness compared to non-khat heart patients (7.5 percent death rate vs. 3.8 percent).

One month out, the risk spread was even greater: a 15.5 percent death rate among khat users vs. 6.4 percent among non-users. And at one year, the death rate was nearly 19 percent among khat users, compared with just under 11 percent among non-users.

Overall, Suwaidi and associates determined that independent of other contributing factors, khat-using heart patients were more likely to experience arrhythmia, heart failure, heart attack or a stroke than non-khat-using heart patients, in addition to facing a higher risk for death, regardless of gender.

"The ease and rapidity of travel [make khat] available in distant places," Suwaidi said. "And hence it is important to be aware of these practices," he noted, adding that prior research suggests that the elevated risk attributed to khat use among heart patients is very likely to also apply to otherwise healthy patients.

Dr. Kirk Garratt, clinical director of interventional cardiovascular research at Lenox Hill Hospital in New York City, commented on the study.

"We know very well that when you have cardiovascular disease any exposure to any meaningful stimulant would be expected to increase heart risk, by changing the vascular dynamic of the blood vessels that control the blood flow through the brain and heart," he said. "We also know that these drugs can facilitate or trigger irregular heart rhythms, which can be very problematic.

"Cocaine, for example, can have a negative impact on people both with and without heart disease," Garratt added. "And those with heart disease face an especially elevated risk. So these findings are not really surprising."

More information

Visit the U.S. National Institute of Drug abuse for more on khat.

SOURCES: Jassim Al Suwaidi, M.D., consultant cardiologist and director, cardiovascular research, department of cardiology and cardiovascular surgery, Hamad General Hospital, Doha, Qatar; Kirk Garratt, M.D., clinical director, interventional cardiovascular research, Lenox Hill Hospital, New York City; Dec. 12, 2011, Circulation


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Chewing Khat Linked to Severe Liver Damage
2. Strict policy raises hospitals worker flu vaccination rate
3. Physically Demanding Work Raises Heart Risk in Unfit Men: Study
4. Experimental Drug for Irregular Heart Rhythm Raises Death Risk: Study
5. Too Much Sitting Raises Odds for Cancer: Study
6. Aging, Not Menopause, Raises Womens Heart Risks, Study Finds
7. Smoking soon after waking raises risk of lung and head and neck cancers
8. Breast Cancer Drug Raises Risk of Heart Problems in Older Women: Study
9. Trastuzumab raises risk of heart problems in the elderly with history of heart disease or diabetes
10. Smoking After Heart Attack Raises Risk of Dying
11. Localized reactive badger culling raises bovine tuberculosis risk, new analysis confirms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chewing Khat Raises Heart Disease, Death Risk: Study
(Date:1/21/2017)... ... January 21, 2017 , ... ... Family Dermatology has recently joined their multi-specialty medical group. The dermatology practice ... cosmetic services. , “We’re excited to add this excellent dermatology practice to our ...
(Date:1/20/2017)... ... ... A new partnership between Goodwill® and Roadie, Inc. aims to make it easier ... couches to dressers and bicycles. Roadie — the national on-the-way delivery network — will ... through February 28th. , “January is an exciting time when resolutions are made ...
(Date:1/20/2017)... ... January 20, 2017 , ... Lice Troopers, the lice removal company based ... school-aged children since the holiday season. , “It happens every year around this ... hugs and taking photos, which is the head-to-head gateway that lice need to spread.” ...
(Date:1/20/2017)... ... 20, 2017 , ... Vitamin Well has launched two new ... have been produced in collaboration with Zlatan Ibrahimovic and have been developed to ... a successful launch in Sweden last year, the next generation sports drinks VW+001 ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... ... vPEP ® Oscillating Positive Expiratory Pressure (OPEP) device, was featured in a study ... Doug Pursley, MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive Expiratory Pressure ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Report Details What can be expected ... to grow at the fastest rates? This visiongain report ... opportunities and prospects. Our 190-page report provides 124 ... in the industry and the future market prospects. Our ... all the major categories of the ophthalmic devices market. ...
(Date:1/19/2017)... 19, 2017 This report on the opioid ... scenario of the global market. Large number of chronic ... chronic constipation is a major side effect of consumption ... novel targeted therapy has been prescribed to treat opioid ... targeted medicines, and growing awareness about the therapy are ...
(Date:1/19/2017)... 2017 Accuray Incorporated (Nasdaq: ARAY ... continue to set the bar for excellence in customer ... user satisfaction rating among radiation treatment delivery systems in ... Market Intelligence Briefing™. The most recent ratings trend also ... industry peers for 11 of the past 12 quarters. ...
Breaking Medicine Technology: