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Chewing Khat Linked to Severe Liver Damage
Date:4/28/2010

Herb appears to lead to liver failure in some, British researchers say

WEDNESDAY, April 28 (HealthDay News) -- Chewing khat leaves for a mild high is popular in East Africa and the Arabian Peninsula, and the practice is also seen among certain immigrant groups in Great Britain and the United States.

But chewing khat can cause severe liver damage and even death, British researchers report.

Khat contains cathinone, an amphetamine-like stimulant that causes euphoria, excitement and loss of appetite. Although banned in the United States, it finds its way to North America from Britain, where it is readily available, the researchers reported in a letter to the editor in the April 29 issue of the New England Journal of Medicine.

Dr. Eugene Schiff, director of the Center for Liver Diseases at the University of Miami Miller School of Medicine in Florida, said the danger posed by khat "is well established in the literature."

"We see this in a variety of herbal substances," he added.

In their letter, Dr. Michael H. Chapman, of University College London Medical School, and his colleagues reported on six patients in Britain who had either died of liver failure or needed liver transplants. The common denominator and suspected cause was the chewing of khat leaves.

The patients were seen over five years and all had been cautioned about khat's risks. One of the patients died and five needed liver transplants, the researchers said.

Chapman's group found no other potential causes for liver damage. Five of the patients had a history of unexplained hepatitis.

Khat has also been linked to mental problems and heart disease, the researchers noted.

While it's not exactly known how khat damages the liver, Chapman's team speculates that it triggers low-level hepatitis, and repeated use leads to chronic liver disease.

Schiff said that when doctors see liver problems
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