Navigation Links
Chew gum, lose weight
Date:11/21/2011

Most people understand that serious weight loss requires changing attitudes toward what they eat and how often they exercise. But, what if the process could be aided by simply chewing a stick of gum after meals? That's the question a team of scientists, led by Syracuse University chemist Robert Doyle, is trying to answer. In a groundbreaking new study, Doyle's team demonstrated, for the first time, that a critical hormone that helps people feel "full" after eating can be delivered into the bloodstream orally.

Doyle's study was published online Nov. 4, 2011 in the American Chemical Society's Journal of Medicinal Chemistry and is forthcoming in print. The journal is the most cited in the field and one of the leading primary research journals internationally. Doyle is an associate professor in the Department of Chemistry in SU's College of Arts and Sciences. He collaborated on the study with researchers from Murdoch University in Australia.

The hormone, called human PYY, is part of a chemical system that regulates appetite and energy. When people eat or exercise, PYY is released into the bloodstream. The amount of PYY that is released increases with the number of calories that are consumed. Past studies have shown that people who are obese have lower concentrations of PYY in their bloodstream both when fasting and after eating than their non-obese counterparts. Additionally, intravenous infusion of PYY into a volunteer group of obese and non-obese individuals increased the serum levels of the hormone and lowered the number of calories both groups consumed.

"PYY is an appetite-suppressing hormone," Doyle says. "But, when taken orally, the hormone is destroyed in the stomach and that which isn't destroyed has difficulty crossing into the bloodstream through the intestines."

What's needed is a way to disguise the PYY so that it can travel through the digestive system relatively unharmed. Several years ago, Doyle developed a way to use vitamin B12 as a vehicle for the oral delivery of the hormone insulin. B12 is able to pass through the digestive system with relative ease and carry with it insulin, or other substances, into the bloodstream. Similarly, his research team attached the PYY hormone to his patent-pending vitamin B12 system. "Phase one of this study was to show that we could deliver a clinically relevant amount of PYY into the bloodstream," Doyle says. "We did that, and we are very excited by the results."

The next step involves finding ways to insert the B12-PYY system into such things as chewing gum or an oral tablet to create a nutritional supplement to assist individuals in losing weight in much the same way as nicotine-laced gum is used to help people stop smoking. "If we are successful, PYY-laced gum would be a natural way to help people lose weight," he says. "They could eat a balanced meal, then chew a stick of gum. The PYY supplement would begin to kick in about three to four hours later, decreasing their appetite as they approach their next meal."


'/>"/>

Contact: Judy Holmes
jlholmes@syr.edu
315-443-8085
Syracuse University
Source:Eurekalert

Related medicine news :

1. Outlook Good for Obese Kids Who Lose Weight
2. Even Without Weight Loss, Mediterranean Diet Helps Heart: Study
3. Losing Weight May Help Fight Gum Disease
4. Looking to Lose Weight? Get a Coach
5. Loss of weight associated with chronic illness may soon have first treatment
6. Primary care-based weight intervention helps obese patients reduce weight
7. Prenatal exposure to environmental pollutants determines weight and size at birth
8. Obese monkeys lose weight on drug that attacks blood supply of fat cells
9. Dairy foods may improve bone health during diet and exercise in overweight premenopausal women
10. Knee Arthritis Striking at Younger Ages, But Weight Loss May Help
11. Fast-Food Outlets Nearby Might Not Cause Weight Gain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... , ... January 20, 2017 , ... A new partnership ... items they no longer use or need, from clothes to couches to dressers and ... items and take them to the nearest Goodwill donation center through February 28th. ...
(Date:1/20/2017)... ... 20, 2017 , ... Lice Troopers, the lice removal company based in South ... since the holiday season. , “It happens every year around this time,” says ... taking photos, which is the head-to-head gateway that lice need to spread.” , As ...
(Date:1/20/2017)... New York, NY (PRWEB) , ... January 20, ... ... drinks – VW+ 001 and its sugar-free alternative VW+ 002. The drinks have ... the body with optimal conditions to perform during your workout. , After a ...
(Date:1/20/2017)... Farmville, NC (PRWEB) , ... January 20, 2017 ... ... the vPEP ® Oscillating Positive Expiratory Pressure (OPEP) device, was featured in ... article by Doug Pursley, MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive ...
(Date:1/20/2017)... ... ... Miracle Man: Against All Odds”: an inspiring affirmation of God’s work. “God's Miracle ... son of Minister Delores Pinnock and a Jamaican native who lives in Kingston and ... up in bed, I felt a pounding headache. It was like a drum beating ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... -- Faruqi & Faruqi, LLP, a leading national securities law firm, ... KMPH ) of the federal securities class action ... and underwriters of the Company,s April 16, 2015 Initial Public ... The lawsuit has been filed in the ... County on behalf of all those who acquired ...
(Date:1/20/2017)... Jan. 20, 2017  Ethicon Endo-Surgery, Inc. ... Medical Products, Inc., a privately held medical ... electrosurgical tools used in operating rooms worldwide. ... Ethicon,s* advanced energy devices with Megadyne,s innovative ... step forward in Ethicon,s goal to deliver ...
(Date:1/20/2017)... BUFFALO, N.Y. , Jan. 20, 2017 /PRNewswire/ ... health programs, has announced the launch of an ... to new guidelines on opioids and helps stem ... Opioids are often prescribed to treat chronic non-cancer ... disease) despite serious risks and lack of evidence ...
Breaking Medicine Technology: