Navigation Links
Chemotherapy's effect on overall survival seems to increase based on tumor size
Date:5/15/2012

DENVER The most recent research released in June's Journal of Thoracic Oncology indicates there might be a positive correlation between tumor size and adjuvant platinum based chemotherapy in surgically resected patients with node negative non-small cell lung cancer. The study, published in the June 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, analyzed the effect of tumor size and KRAS mutations on survival benefit from adjuvant platinum based chemotherapy in patients with node negative non-small cell lung cancer.

The purpose of the retrospective study was to apply the most current, 7th edition, TNM staging system, to a retrospective cohort of surgically resected, node negative, non-small cell lung cancer patients who were treated with adjuvant platinum based chemotherapy. Previous clinical trials confirmed a survival benefit for adjuvant platinum based chemotherapy for patients with stage II-IIIa non-small cell lung cancer. In addition, the authors explored the interaction between tumor size and KRAS mutations in predicting a benefit from the chemotherapy.

After analyzing data from 461 patients that were part of two previous adjuvant trials, JBR.10 and CALBG 9633, the authors found a positive correlation between the size of the tumor and efficacy of chemotherapy with respect to disease free survival. There was no clear demarcation of what T size threshold correlated with benefit of chemotherapy. KRAS mutation was detected in 27 percent of the specimens, correlated with a worse prognosis but not with the size of the tumor.

"Thus, our study reinforces the pressing need for improved understanding of the impact of the new T-size descriptors on adjuvant chemotherapy effect," the authors say. "This is particularly valid when we consider that up to 77 percent of surveyed lung cancer physicians would alter patient management in response to a change in stage designation."


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@IASLC.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
2. Researchers see BPA effects in monkey mammary glands
3. Aspirin as Effective as Warfarin for Heart Failure: Study
4. Lower-Dose Radioiodine Effective Against Thyroid Cancer
5. Moffitt researcher publishes book on nutritional management of cancer treatment effects
6. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
7. Pig stomach mucins are effective as anti-viral agents for consumer products
8. HIV Prevention Pill Cost-Effective for High-Risk Men: Study
9. Study examines adverse effects among different radiation therapies for prostate cancer
10. Baldness Drug May Cause Sexual Side Effects: FDA
11. Breast Cancer Treatment Side Effects May Last for Years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... (PRWEB) , ... February 21, 2017 , ... Support of ... To simplify the secure exchange of data across industry solutions, Fogo Data Centers announces ... power of community. A healthy community is one in which all systems work ...
(Date:2/21/2017)... ... February 21, 2017 , ... Each February the nation ... (officially African American History Month ). This month-long celebration encourages ... diverse race of people, but also the opportunity to examine the trends of ...
(Date:2/21/2017)... ... February 21, 2017 , ... One of the ... the medical, mental health, and financial consequences of inaction. On March 3, World ... if they have concerns about their hearing. , Effective treatment in the form ...
(Date:2/21/2017)... ... , ... Along with Valentine’s Day, February marks American Heart Month, a great ... to a lifetime of heart health. In addition, it is a time to ... Athletic Trainers’ Society of New Jersey (ATSNJ) is urging sports programs to prepare comprehensive ...
(Date:2/20/2017)... ... , ... Nancy Johnston Toll marks her debut in the publishing ... Bump in the Road ” (published by Xlibris). Inspired from her personal experiences, this ... ups and downs experienced by anyone going through cancer treatment and how one can ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Cognitive Computing for Cancer has revolutionized ... previously unattainable level of personalized treatment options with ... is anticipated that the Global Cancer Cognitive Computing ... The growth of the market is likely to ... installation of cognitive computing software in hospitals, increasing ...
(Date:2/21/2017)... -- /PR Newswire/ -- UBM Medica,s Eye Care Group ( ... Modern Retina ( www.modernretina.com ), a new ... Built upon the success of Ophthalmology Times , ... in the areas of retinal surgery, clinical information, research, ... informational needs and filling existing educational gaps, Modern ...
(Date:2/21/2017)... BANGALORE , February 21, 2017 ... Appropriate Technology for Adoption by Plastic Industry  ... STEER, ... and functionalise materials in the fields of plastics, pharmaceuticals, ... collaboration with Merck KGaA, Darmstadt, Germany ...
Breaking Medicine Technology: