Navigation Links
Chemotherapy might help cancer vaccines work
Date:5/15/2008

DURHAM, N.C. Chemotherapy given in conjunction with cancer vaccines may boost the immune systems response, potentially improving the effectiveness of this promising type of cancer therapy, according to a study by researchers in the Duke Comprehensive Cancer Center.

Chemotherapy first knocks out T regulatory cells that suppress immune function and we speculated that this might have a complementary effect when used in conjunction with vaccines, which work by boosting immune function, said Timothy Clay, Ph.D., a researcher at Duke and a lead investigator on this study. We tested this theory both pre-clinically and in patients who were part of a vaccine trial at Duke for gastrointestinal cancers, and found that our hypothesis seemed to be true.

The researchers will present their findings at the annual American Society of Clinical Oncology meeting in Chicago, on May 31. The study was funded by the National Cancer Institute.

Researchers used a drug called denileukin diftitox (ONTAK) for this study; the drug is routinely used to treat a type of lymphoma and is known to deplete certain types of immune cells including the T regulatory cells that put the brakes on immune function. They speculated it might facilitate better immune responses to a cancer vaccine.

In the lab work, we definitely saw a heightened immune response when we used the denileukin diftitox in conjunction with the vaccine. The vaccine we used targets a protein found in gastrointestinal tumors and works by boosting immune response to the cells carrying that protein, Clay said. From there, we gave the drug to 15 patients in a phase I study using the vaccine.

The researchers found that when multiple doses of the denileukin diftitox were given, immune response to the vaccine was enhanced in these patients.

This is encouraging. The next step will be to develop better drugs that support vaccines by enhancing the immune response they depend on to work,
'/>"/>

Contact: Lauren Shaftel Williams
lauren.shaftel@duke.edu
919-684-4966
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chemotherapy may be culprit for fatigue in breast cancer survivors
2. Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
3. To evade chemotherapy, some cancer cells mimic stem cells
4. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
5. PET scans can accurately detect a breast tumors response to chemotherapy
6. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
7. Medicare modernization act did not change chemotherapy as feared
8. HER-2 status predicts success of chemotherapy in breast cancer treatment, study finds
9. Cancer conflict with chemotherapy treatment
10. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
11. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... An inventor from Buffalo, N.Y., knows ... life, and she wants to lessen its impact. "After ... decided that there needed to be a way to ... to use and producible in design variations, the End ... areas throughout the day. It avoids bad odors, as ...
(Date:11/27/2014)... New York (PRWEB) November 27, 2014 ... ) have been filed in a consolidated litigation ... LLP reports. , Documents recently updated in ... records included in the state proceeding, all of ... bipolar disorder and other psychiatric conditions. Many of ...
(Date:11/27/2014)... WEDNESDAY, Nov. 26, 2014 (HealthDay News) -- Most babies ... a cold, the U.S. Food and Drug Administration says. ... be given to children younger than 2 because they ... agency warned. American adults average about three colds ... children get a cold, parents might want to give ...
(Date:11/27/2014)... (HealthDay News) -- Thanksgiving meals can pose a challenge ... an expert says. Many traditional Thanksgiving dishes -- ... -- are gluten-free, but "when it comes to pies, ... considered," Dr. Anca Safta, director of the Gluten and ... Center in North Carolina, said in a center news ...
(Date:11/27/2014)... The founders of VIM & VIGR, a company ... compression socks, are proud to announce the debut of their ... Pressure (TM) knitting technology that is designed to increase the ... to adding flair and style to a product that has ... eye of a writer at The New York Times ...
Breaking Medicine News(10 mins):Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 2Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 3Health News:New Risperdal Lawsuits Added to Philadelphia Litigation, Bernstein Liebhard LLP Reports 4Health News:Steer Clear of Cold Meds for Babies, FDA Advises 2Health News:Expert Shares Gluten-Free Thanksgiving Tips 2Health News:VIM & VIGR Announces Launch of Men’s Line of Compression Socks 2
... Satisfaction Can Lead to Relationship, Quality-of-Life ... ... Leading sexual wellness experts,who attended a satellite symposium of the American ... agreed that,better intimacy can lead to better relationships and ultimately, better,overall ...
... threat, study finds, , , WEDNESDAY, Nov. 12 (HealthDay News) -- Whether ... you have a higher risk of dying than someone of normal ... to collect their weight around the middle -- apple-shaped -- face ... tends to settle in their hips and thighs -- pear-shaped. ...
... Medical Simulation Corporation (MSC),announces a new partnership with the ... and education services for USF Health hospital partners and ... education. The MSC SimSuite Education Center is located at ... , "MSC is excited to partner with USF Health ...
... cost-containment. , ... Alexandria, VA (Vocus) November 12, 2008 ... Chain Drug Stores (NACDS) Steven C. Anderson, IOM, CAE issued a ... Finance Committee Chairman Max Baucus (D-MT) today:, , , , ,“It ...
... that Hydrates and Soothes Young Throats Now Available,Across ... As cough and cold season,rapidly approaches, Integrated ... and nutrition products has launched its newest product,in ... product is a perfect choice for parents who ...
... industry award for 2008, WASHINGTON, Nov. ... of furniture for healthcare environments, today announced ... Nightingale Award at the,annual Healthcare Design 08 ... workspace solution, SYNC(TM)., (Photo: http://www.newscom.com/cgi-bin/prnh/20081112/AQW138 ...
Cached Medicine News:Health News:Experts at American Society for Reproductive Medicine (ASRM) Satellite Symposium Reach Consensus: Better Intimacy = Better Overall Well-Being 2Health News:Experts at American Society for Reproductive Medicine (ASRM) Satellite Symposium Reach Consensus: Better Intimacy = Better Overall Well-Being 3Health News:Excess Weight Ups Risk of Death, No Matter Where It Collects 2Health News:Medical Simulation Corp. announces partnership with University of South Florida 2Health News:As Chairman Baucus Outlines Vision for Healthcare Reform, NACDS Emphasizes Pharmacy's Essential Role in Any Successful Overhaul 2Health News:Integrated Beverage Group Launches Children's Throat Cooler(R) in Canada 2Health News:Integrated Beverage Group Launches Children's Throat Cooler(R) in Canada 3Health News:Nurture(R) by Steelcase Wins Second Consecutive Nightingale Award for SYNC(TM) Caregiver Workspace Solution 2Health News:Nurture(R) by Steelcase Wins Second Consecutive Nightingale Award for SYNC(TM) Caregiver Workspace Solution 3
(Date:11/26/2014)... A hernia is condition in which a tissue, ... of a weak muscle area. Obesity, poor nutrition, smoking, and ... causes of hernias. There are several types of hernia such ... is when part of the abdominal tissue/organ protrudes into the ... of the umbilicus. A hiatal hernia is when a portion ...
(Date:11/26/2014)... NEW YORK and LONDON ... distributor of market intelligence, MarketResearch.com is pleased to announce ... Research and Consultancy focusing on the active pharmaceutical ingredient ... Research visit: http://www.marketresearch.com/land/publisher.asp?vendorid=4023&progid=86891 . In ... Market – Forecast to 2020 , ...
(Date:11/26/2014)... YORK , Nov. 25, 2014  Medtronic,s ... Covidien has been widely discussed in the ... it,s also creating a stronger leading player in ... to Kalorama Information.  The healthcare market research firm ... systems will feature a diverse set of solutions ...
Breaking Medicine Technology:Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 3Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 4MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
... from a 52-week phase 3,study (LEADTM 3) of ... once-daily,human GLP-1 analog, were published online today in ... alone, produces statistically,significant and sustained improvements in blood ... as compared with glimepiride, a widely used,oral anti-diabetic ...
... Calif., Sept. 25 Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: ... symptomatic intracranial hemorrhage in an earlier European,trial of ... ischemic,stroke may be minimized with avoidance of prolonged ... pressure entry criteria., The data, presented today ...
Cached Medicine Technology:Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet 2Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet 3Analysis of Earlier European Stroke Trial Supports Treatment Regimen for Viprinex(TM) in Current International Phase 3 Clinical Trials 2Analysis of Earlier European Stroke Trial Supports Treatment Regimen for Viprinex(TM) in Current International Phase 3 Clinical Trials 3Analysis of Earlier European Stroke Trial Supports Treatment Regimen for Viprinex(TM) in Current International Phase 3 Clinical Trials 4
Shoulder rasp...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
85 left angled suture passer....
45 right angled suture passer....
Medicine Products: