Navigation Links
Chemotherapy combination outcomes differ for aged, younger colon cancer patients
Date:5/29/2009

ORLANDO, Fla.--The combination of chemotherapies 5FU and oxaliplatin compared to 5FU alone after surgery for colon cancer decreases colon cancer recurrence and promotes longer survival for patients under 70 -- but not for those who are older, according to Mayo Clinic and Dana-Farber Cancer Institute scientists who will present their findings at the American Society of Clinical Oncology's (ASCO) annual meeting in Orlando, Fla.

"By combining information about many patients from a collection of studies, our analysis determined that the more aggressive combination chemotherapy does not benefit older colon cancer patients as it does for those who are younger," said Nadine Jackson McCleary, MD, PhD, Dana-Farber gastrointestinal oncologist and the lead author on the study. Jackson-McCleary is the recipient of a 2008-2009 ASCO Young Investigator's Award.

The data (abstract 4010) will be presented on Saturday, May 30, 3 p.m. ET (Level 2, West Hall D2).

Adding oxaliplatin to chemotherapy treatment with 5FU reduces the risk of recurrence among patients less than 70 years of age who have had their primary cancer removed, the study determined, a finding that was expected based on the results of previous individual trials. Patients under 70 who were treated with 5FU and oxaliplatin had improved disease-free survival, with the addition of oxaliplatin relatively reducing the risk of recurrence or death by approximately 15 percent. Those patients aged 70 and older who were treated with the combined drug therapy, however, did not have improved outcomes compared to patients who received 5FU alone.

"We found that adding chemotherapy agents to the standard 5FU regimen in older patients after surgery did not provide the benefits that younger patients see," Dan Sargent, PhD, Mayo Clinic, a collaborator on the study, agreed. "For the older patient, this means that it is appropriate to choose the better tolerated treatment strategy of 5FU alone."'/>"/>

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
440-670-6563
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Compliance and cost: Bitter pills to swallow in the age of oral chemotherapy
2. Rexin-G Controls Tumor Growth and Improves Survival in Chemotherapy-Resistant Sarcoma and Osteosarcoma: Phase I/II and Phase II Studies, ASCO 2009
3. Study shows chemotherapy improves survival among older breast cancer patients
4. Chemotherapy Superior to New Drug for Early Breast Cancer
5. Retrospective Analysis Finds Treatment of Cancer Chemotherapy Patients With Epoetin Alfa Associated With Lower Drug Cost Than Darbepoetin Alfa
6. 3-drug chemotherapy combination increases organ preservation in patients with larynx cancer
7. Scientists trial device to treat chemotherapy-related nausea
8. Lung Cancer Microscopic Appearance Affects Response to Chemotherapy
9. Sequential and alternating chemotherapy and radiation equally effective in larynx cancer therapy
10. How chemotherapy drugs block blood vessel growth, slow cancer spread
11. UNC study supports role of circadian clock in response to chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 ... business sector recently launched a “Video” section located ... and general information on various cannabis companies in ... can find an assortment of news clips, interviews, ... and announcements. A portion of the videos can ...
(Date:8/28/2014)... The Foundation for Women’s Cancer will ... alerting women to the link between obesity and endometrial ... endometrial cancer. , Endometrial cancer is the most ... More than 52,600 will learn of a diagnosis this ... weight management challenges to know the early warning signs ...
(Date:8/28/2014)... veEDIS Clinical Systems, LLC has successfully ... in Lawrence Medical Center, located in Moulton, Alabama. ... patient care, veEDIS is a key ingredient in ... the authorized, confidential exchange of patient information at ... designed in accordance with clinical workflows and best ...
(Date:8/28/2014)... Baltimore, MD (PRWEB) August 28, 2014 ... has received Diamond level Allergan Privilege Program status ... widely used treatments as Botox, Juvederm, and Voluma. Maryland ... exemplary and prolific use of these treatments. The dermatologists ... in injectable treatments, and are one of the leading ...
(Date:8/28/2014)... It is not uncommon for people to sink into ... face ridicule and judgment and find it easier to just ... why they keep gaining weight and just cannot seem to ... eating more and gaining more, leaving them feeling distain toward ... helped thousands safely, successfully and rapidly improve their confidence ...
Breaking Medicine News(10 mins):Health News:Emerging Cannabis Industry Website GreenRushReview.com Adds a Featured Video Section to Cover Marijuana Business Sector News 2Health News:Emerging Cannabis Industry Website GreenRushReview.com Adds a Featured Video Section to Cover Marijuana Business Sector News 3Health News:Foundation for Women's Cancer Alerts Women to Link Between Obesity and Endometrial Cancer 2Health News:veEDIS Clinical Systems “Delivers,” as the 2014 Edition CEHRT Emergency Department EHR System is Implemented at Lawrence Medical Center 2Health News:veEDIS Clinical Systems “Delivers,” as the 2014 Edition CEHRT Emergency Department EHR System is Implemented at Lawrence Medical Center 3Health News:Maryland Laser Skin and Vein Receives Diamond Status From Allergan 2Health News:Diet Doc’s Medical Weight Loss Programs Announce New Help for Patients Who Want to Overcome Depression Caused by Excess Weight 2Health News:Diet Doc’s Medical Weight Loss Programs Announce New Help for Patients Who Want to Overcome Depression Caused by Excess Weight 3
... electronic, and patients, caregivers, and healthcare providers are ... health information. Now three institutions are teaming up ... best access this information. The Children,s ... based in Philadelphia, are partnering with Boston public ...
... for hepatitis C patients with end-stage liver disease are nearly ... to a Henry Ford Hospital study. Although infection ... the specific impact of the disease,s progressive severity on health ... severity of hepatitis C-related liver disease increases with age, and ...
... Scientists at Rochester Institute of Technology and Dowling College are ... cards, they are matching the protein to the job it ... drugs that target proteins and switch on or off specific ... funded by a $417,000 grant from the National Institutes of ...
... destroyed in type 1 diabetes Type 1 ... of sugar (glucose) in the blood. It is caused ... cells in their pancreas that produce the hormone insulin, ... about the mechanisms regulating the sensitivity and resistance of ...
... HealthDay Reporter , SUNDAY, Nov. 6 (HealthDay News) ... evoke the holiday season for some. For others, those ... noses and sneezing to asthma attacks. Allergists say ... have complaints from their patients about reactions to them. ...
... become fathers for the first time, they show significant decreases ... 19-year study. Researchers assessed more than 200 at-risk boys ... how men,s crime, tobacco, alcohol, and marijuana use changed over ... man,s negative behavior, they had not isolated the additional effects ...
Cached Medicine News:Health News:Grant will help bridge digital divide for people with disabilities 2Health News:Grant will help bridge digital divide for people with disabilities 3Health News:The economic cost of advanced liver disease 2Health News:Opening the data bank -- scientists try to match new protein structures 2Health News:JCI online early table of contents: Nov. 7, 2011 2Health News:JCI online early table of contents: Nov. 7, 2011 3Health News:JCI online early table of contents: Nov. 7, 2011 4Health News:JCI online early table of contents: Nov. 7, 2011 5Health News:JCI online early table of contents: Nov. 7, 2011 6Health News:Air Fresheners, Scented Candles May Spur Allergic Reactions 2Health News:Air Fresheners, Scented Candles May Spur Allergic Reactions 3Health News:Fatherhood can help change a man's bad habits 2
(Date:8/27/2014)... Aug. 27, 2014 About 8 million Americans ... to buildup of fatty plaque in the arteries, according ... patient population and in incidences of diabetes and obesity, ... Lower Extremity Arterial RevascularizatioN (LEARN) meeting, Oct. ... specialists and interested residents and fellows will be able ...
(Date:8/27/2014)... LOS ANGELES , Aug. 27, 2014   ... , now offers AcceleDent® Aura to patients who want ... to orthodontic care available at the OrthoSpaceship, all patients ... healthier, better-looking teeth. This system can be used by ... boost their rate of progress by using the AcceleDent® ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Global Heart ... http://www.reportlinker.com/p02316644/Global-Heart-Valve-Repair-and-Replacement-Market-2014-2018.html About Heart ... in the human heart which control the flow ... affected with heart valve diseases such as valvular ...
Breaking Medicine Technology:LEARN to Treat Peripheral Arterial Disease Patients 2LEARN to Treat Peripheral Arterial Disease Patients 3Los Angeles Orthodontist, Dr. Isaac Hakim, is Now Offering AcceleDent Aura 2Global Heart Valve Repair and Replacement Market 2014-2018 2Global Heart Valve Repair and Replacement Market 2014-2018 3Global Heart Valve Repair and Replacement Market 2014-2018 4
... Dec. 14, 2010 Samplify Systems, Inc., a ... the ultrasound market, is pleased to announce that ... has won Electronic Design Magazine,s Best ... category.  Details of Samplify,s AutoFocus™ beamforming technology currently ...
... 14, 2010 Pacira Pharmaceuticals, Inc. ... the New Drug Application (NDA) for EXPAREL™, a long-acting ... filing by the U.S. Food and Drug Administration (FDA). ... the initial indication of postsurgical analgesia by local administration. ...
Cached Medicine Technology:Samplify's AutoFocus™ Beamforming Technology Awarded Electronic Design's 'Best of 2010' 2
... benchtop coagulation analyzers feature Stago's ... detection. This method eliminates interference ... optically dense samples or reagents. ... preprogrammed assays with curve storage, ...
The CA-50 is a compact semi-automated coagulation analyzerproviding 4-parameter random access....
HemoSite meter can be used to measure the effects of transfusion or the treatment of deficiency states. It is fast, easy, convenient and discrete....
... II is a fully automated analyzer that ... hands-on time by the operator. The Variant ... specimen tubes. It reads the bar code, ... injects the specimen into the chromatographic station ...
Medicine Products: