Navigation Links
Chemotherapy causes delayed severe neural damage
Date:4/21/2008

Cancer treatment with chemotherapeutic agents is often associated with delayed adverse neurological consequences - an occurrence often referred to as chemobrain - that may compromise the quality of life of a proportion of cancer survivors. Now, research published in the open access Journal of Biology demonstrates that treatment with a single chemotherapeutic agent, 5-fluorouracil (5-FU), by itself is sufficient to cause a syndrome of delayed degeneration in the central nervous system (CNS). 5-FU is a widely used chemotherapeutic agent that is employed, alone or in combination with other agents, in the treatment of cancers of the colon, rectum, breast, stomach, pancreas, ovaries and bladder.

Little is known about the side-effects of chemotherapy on the CNS, despite their obvious clinical importance. Until now researchers have not fully understood the underlying biology, including whether these effects require: exposure to multiple chemotherapeutic agents; chemotherapeutic agents plus the bodys own response to cancer; blood-brain barrier damage; or inflammation. Clinicians have also lacked animal models to study this important problem.

Professor Mark Noble and colleagues of the University of Rochester Stem Cell and Regenerative Medicine Institute and the Harvard Medical School, Boston discovered that short-term systemic administration of 5-FU to mice caused both acute CNS damage and a syndrome of progressively worsening delayed damage. This damage was not self-repairing, and instead became worse over time. In addition, Noble and colleagues also demonstrated that treatment with chemotherapy also had delayed effects on the speed with which information is transferred from the ear to the brain.

Myelin sheaths are necessary for normal neuronal function. One key finding of the study was that clinically relevant concentrations of 5-FU were toxic not only for dividing cells of the CNS but also for the cells that produce the insulating myelin sh
'/>"/>

Contact: Charlotte Webber
charlotte.webber@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chemotherapy may be culprit for fatigue in breast cancer survivors
2. Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
3. To evade chemotherapy, some cancer cells mimic stem cells
4. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
5. PET scans can accurately detect a breast tumors response to chemotherapy
6. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
7. Medicare modernization act did not change chemotherapy as feared
8. HER-2 status predicts success of chemotherapy in breast cancer treatment, study finds
9. Cancer conflict with chemotherapy treatment
10. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
11. Jefferson researchers show chemotherapy and radiation together extend lung cancer patients lives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... 07, 2015 With recent headlines about the ... Kong by 6 men from Southern China, it is becoming ... a real concern for them. This is especially true for ... may attract unwanted attention through the property they own, the ... look. Fortunately for those individuals, families and companies that are ...
(Date:5/6/2015)... May 06, 2015 RPS Revolution - a ... the tried and true Rock Paper Scissors game - is ... characters that encourage storytelling and easy to learn rules from ... on an old favorite. RPS Revolution takes the ... whimsical characters that are grouped in set of three called ...
(Date:5/6/2015)... May 06, 2015 Edvance360 LMS-SN ... announced it won the Software & Information Industry ... in the "Best Postsecondary Learning Management Solution" category. ... has been finalists for this award seven years running, ... stands out in the industry. , "The honor ...
(Date:5/6/2015)... Los Angeles, CA (PRWEB) May 06, 2015 ... titled “16 Celebrities on Plastic Surgery ,” compiled ... of celebs includes Jennifer Aniston, pop singer Iggy Azalea, ... quote indicates their sentiments about having plastic surgery ... a statement about society and its expectations of youth ...
(Date:5/6/2015)... 2015 Experienced Vancouver air conditioning installation ... that they will now conduct their cooling services, including ... addition to commercial and residential units. Strata complex air ... lot of technical knowledge as well as a professionally ... we will take away any old air conditioning unit ...
Breaking Medicine News(10 mins):Health News:Pacific Prime China Now Offering Kidnapping & Ransom Insurance 2Health News:RPS Revolution Launches Kickstarter Campaign 2Health News:RPS Revolution Launches Kickstarter Campaign 3Health News:Edvance360 Wins 2015 CODiE Award for Best LMS, Winning Twice and Maintaining Finalist Status for Seven Years Running 2Health News:Edvance360 Wins 2015 CODiE Award for Best LMS, Winning Twice and Maintaining Finalist Status for Seven Years Running 3Health News:Plastic Surgery: Sixteen Celebrities Offer their Opinion about Going Under the Knife 2Health News:Pro Ace Care Now Does Air Conditioning Installation for Strata Complexes 2
... the Lead" PSA to highlight Childhood Overweight and Obesity ... of Health and Human Services, Office of the Surgeon ... "Take the Lead" and in Spanish, "Mi Cocina," on ... families to be physically active and eat healthy foods. ...
... Booth #3974) -- Harris Corporation (NYSE: ... "CTisUS" ( www.ctisus.com ) to deliver intuitive ... and other allied healthcare professionals who access the site ... was created and is maintained by The Advanced Medical ...
... Network CHICAGO, April 6 (HIMSS,09, Booth #3974) ... HRS ) for the CONNECT solution supporting the ... general availability by the U.S. Department of Health and ... in the network can now leverage CONNECT to achieve ...
... CITY, Mich., April 6 "The first ... is that automation applied to an efficient operation ... automation applied to an inefficient operation will magnify ... (CHW) has experienced the positive effects of technology ...
... April 6 What is the relationship between latent ... this relationship. The scientists measured the percentage of fat ... individuals with an identical genetic background and surrounding. The ... a certain latent virus, and the other did not. ...
... Self-Insurance for Medical Benefits, Movement to Direct Contracting ... from HealthLeaders-InterStudyNASHVILLE, Tenn., April 6 HealthLeaders-InterStudy, the ... that between January 2008 and July 2008 enrollment ... directly with a pharmacy benefit manager (PBM), also ...
Cached Medicine News:Health News:U.S. Department of Health & Human Services Releases Public Service Announcements to Encourage Healthy Lifestyles 2Health News:Harris Corporation Redesigning Popular Radiology Web Site to Enhance Content Management and Accessibility 2Health News:CONNECT Solution for Nationwide Health Information Network Released For General Availability by U.S. Government 2Health News:CONNECT Solution for Nationwide Health Information Network Released For General Availability by U.S. Government 3Health News:Children's Hospital of Wisconsin Extends Real-Time Asset Tracking and Automated Charge Capture to their New Patient Pavilion 2Health News:Children's Hospital of Wisconsin Extends Real-Time Asset Tracking and Automated Charge Capture to their New Patient Pavilion 3Health News:Children's Hospital of Wisconsin Extends Real-Time Asset Tracking and Automated Charge Capture to their New Patient Pavilion 4Health News:Effective Weight Management with Gene-Eden, a New Dietary Supplement Based on Dr. Hanan Polansky's Discovery 2Health News:Enrollment in Employer-Contracted Pharmacy Benefit 'Carve-Out' Increased by More than Six Million Lives 2
(Date:5/6/2015)... PARIS , May 6, 2015 ... the development and manufacture of filtration products, mainly for ... ZenPure designs custom filters manufactured in a state-of-the-art plant ... are marketed and sold across the globe and will ... Plastics business. This acquisition is fully in ...
(Date:5/6/2015)... , May 06, 2015 Research and Markets ... addition of the "Global Suture Industry Report ... The Global Suture Industry Report 2015 is a ... of the suture industry. The report ... definitions, classifications, applications and industry chain structure. The ...
(Date:5/6/2015)... 6, 2015 Fibich, Leebron, Copeland, Briggs & ... settlement has been reached to resolve lawsuits involving individuals ... Actos. Actos - manufactured by Takeda Pharmaceuticals - has ... cancer. Several of the firm,s attorneys were instrumental in ... Tommy Fibich - Founding Partner of Fibich, ...
Breaking Medicine Technology:Saint-Gobain Acquires ZenPure, a Specialist in Filtration Products 2Global Suture Industry Report 2015 - Forecast Trends to 2021 2Global Suture Industry Report 2015 - Forecast Trends to 2021 3Takeda Agrees to $2.4 Billion Settlement for Actos Bladder Cancer Lawsuits 2
... tissue processor features superior user comfort with ... fully enclosed, stand-alone system for processing of ... tissue processor combines proven technology with an ... easy to use,yet powerful software. Many routine ...
... The Leica TP1020 product family are semi-enclosed ... perfect combination of approved technology with modern ... and maximum safety for tissues at all ... design based on proven precision mechanics in ...
... new tissue infiltration instrument, which combines well-proven ... The robust caroussel design is proven and ... instrument includes either 10 reagent and 2 ... paraffin containers. Up to 10 different programs ...
... unique sliding microtome with automatic fine/trim- ... travel. Maintenance-free precision cross roller bearings. ... specialty applications in biological, botany, and ... 155 x 90 mm can be ...
Medicine Products: