Navigation Links
Chemo Plus Synthetic Drug Shrunk Pancreatic Tumors

Research with mice might one day yield new therapies, study says

THURSDAY, March 25 (HealthDay News) -- When used with chemotherapy, an experimental synthetic drug called JP1201 was effective against human pancreatic cancer in mice, a new study found.

JP1201 mimics that action of a naturally occurring protein (Smac) that triggers cell death.

In this study, researchers gave JP1201 and the chemotherapy drug gemcitabine to mice with transplanted human pancreatic tumors.

"There was a 50 percent regression in tumor size during a two-week treatment of the mice," study senior author Dr. Rolf Brekken, an associate professor of surgery and pharmacology at the University of Texas Southwestern Medical Center in Dallas, said in a news release from the medical center.

The combination treatment also prolonged the life of the mice. The finding could lead to more effective therapies for pancreatic and possibly other cancers, the researchers said.

The study was published March 23 in the journal Cancer Research.

"This compound enhanced the efficacy of chemotherapy and improved survival in multiple animal models of pancreatic cancer. We now have multiple lines of evidence in animals showing that this combination is having a potent effect on pancreatic cancer, which is a devastating disease," Brekken said.

The research was supported by Joyant Pharmaceuticals, a Dallas-based company and UT Southwestern spinoff that's developing medical applications of compounds that mimic that action of the Smac protein.

More information

The American Cancer Society has more about pancreatic cancer.

-- Robert Preidt

SOURCE: UT Southwestern Medical Center, news release, March 23, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Chemo May Boost Survival After Lung Cancer Surgery
2. Recommended Dental Care for Chemotherapy Patients -- Advice from Steven McConnell, DDS
3. Chemotherapy plus synthetic compound provides potent anti-tumor effect in pancreatic cancers
4. Researchers find new chemotherapy combination shows promise in endometrial cancer
5. BioSphere Medical's HepaSphere Microspheres Safely Deliver Doxorubicin in Liver Cancer Chemoembolization Therapy -- Study Presented at SIR
6. Are New Chemo Treatments Cost-Effective?
7. Older Colon Cancer Patients Less Likely to Get Chemo
8. Study evaluates costs and benefits of new chemotherapy drugs
9. Scientists identify microRNA as possible cause of chemotherapy resistance
10. Roche/Genentech/Chugais Herceptin as an Add-On to Standard Chemotherapy Will Become Decision Resources Clinical Gold Standard in 2013 for the Treatment Of Gastric Cancer
11. New developments in nanotechnology tackle the 2 biggest problems associated with chemotherapy
Post Your Comments:
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic Software helps ... creates an agreement between the practice owner and the patient that automatically manages ... and projections. Click here to learn more. , According ...
(Date:11/24/2015)... ... 2015 , ... New patients who wish to seek treatment for missing teeth ... at her Mississauga, ON practice. Dr. Williams has been providing dental service for over ... , Missing teeth can lead to a variety of complications if they are not ...
(Date:11/24/2015)... ... November 24, 2015 , ... ThirdLove, the fast-growing ... a week early, offering 40% off select bras and underwear styles, now through ... both mobile fit technology and the latest fashion, quickly becoming the next generation ...
(Date:11/24/2015)... ... November 24, 2015 , ... DMG Productions announced that they will feature ... quarter 2016 via Discovery Channel. Dates and show times TBA. , Aphria, Inc., is ... the business of producing and supplying medical marijuana pursuant to the Marijuana for Medical ...
(Date:11/24/2015)... Lake City, UT (PRWEB) , ... November 24, 2015 , ... ... to Forbes Magazine. For a business, it is critical that the first impression be ... a business, they are not likely to buy anything or want to return. They ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 On Tuesday, ... federal bellwether trial against Wright Medical Technology, Inc. ... their Conserve metal-on-metal hip implant device, awarded $11 ... a two week trial and three days of ... hip device was defectively designed and unreasonably dangerous, ...
(Date:11/25/2015)...  ARKRAY USA , Inc., a ... demonstrating the accuracy of its blood glucose meter systems. ... Diabetes and Cardiovascular Disease in Los Angeles ... ® 01 meter and the Assure ® ... to accurately measure glucose levels in blood is essential ...
(Date:11/25/2015)... MELVILLE, N.Y. , Nov. 25, 2015  Henry ... products and services to office-based dental, medical and animal ... Dental (GNYDM) Meeting the Henry Schein ConnectDental® Pavilion ... industry,s broadest array of open solutions designed to help ... Click here for a schedule of ...
Breaking Medicine Technology: