Navigation Links
Chemo Plus Synthetic Drug Shrunk Pancreatic Tumors
Date:3/25/2010

Research with mice might one day yield new therapies, study says

THURSDAY, March 25 (HealthDay News) -- When used with chemotherapy, an experimental synthetic drug called JP1201 was effective against human pancreatic cancer in mice, a new study found.

JP1201 mimics that action of a naturally occurring protein (Smac) that triggers cell death.

In this study, researchers gave JP1201 and the chemotherapy drug gemcitabine to mice with transplanted human pancreatic tumors.

"There was a 50 percent regression in tumor size during a two-week treatment of the mice," study senior author Dr. Rolf Brekken, an associate professor of surgery and pharmacology at the University of Texas Southwestern Medical Center in Dallas, said in a news release from the medical center.

The combination treatment also prolonged the life of the mice. The finding could lead to more effective therapies for pancreatic and possibly other cancers, the researchers said.

The study was published March 23 in the journal Cancer Research.

"This compound enhanced the efficacy of chemotherapy and improved survival in multiple animal models of pancreatic cancer. We now have multiple lines of evidence in animals showing that this combination is having a potent effect on pancreatic cancer, which is a devastating disease," Brekken said.

The research was supported by Joyant Pharmaceuticals, a Dallas-based company and UT Southwestern spinoff that's developing medical applications of compounds that mimic that action of the Smac protein.

More information

The American Cancer Society has more about pancreatic cancer.



-- Robert Preidt



SOURCE: UT Southwestern Medical Center, news release, March 23, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Chemo May Boost Survival After Lung Cancer Surgery
2. Recommended Dental Care for Chemotherapy Patients -- Advice from Steven McConnell, DDS
3. Chemotherapy plus synthetic compound provides potent anti-tumor effect in pancreatic cancers
4. Researchers find new chemotherapy combination shows promise in endometrial cancer
5. BioSphere Medical's HepaSphere Microspheres Safely Deliver Doxorubicin in Liver Cancer Chemoembolization Therapy -- Study Presented at SIR
6. Are New Chemo Treatments Cost-Effective?
7. Older Colon Cancer Patients Less Likely to Get Chemo
8. Study evaluates costs and benefits of new chemotherapy drugs
9. Scientists identify microRNA as possible cause of chemotherapy resistance
10. Roche/Genentech/Chugais Herceptin as an Add-On to Standard Chemotherapy Will Become Decision Resources Clinical Gold Standard in 2013 for the Treatment Of Gastric Cancer
11. New developments in nanotechnology tackle the 2 biggest problems associated with chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... ... Erlanger Agency has announced a new partnership in its ongoing community involvement ... the fight against breast cancer, fundraising for a local woman named Carmen, who is ... is a loving single mother of two boys who also serves as caregiver for ...
(Date:2/12/2016)... ... 2016 , ... Donor Network West, the organ procurement organization that heals lives ... San Ramon Regional Medical Center. Under the collaboration, the first of its kind, specific ... a more certain time frame for donor families for the recovery of organs. ...
(Date:2/12/2016)... ... February 12, 2016 , ... For Coast Dental dentist Everet Lake, ... and dental assistant Terrell Moore shortly before 7 a.m. to volunteer at Friday’s Dentistry ... donating their time and skills to help hundreds of uninsured and underinsured people receive ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... Cancer Care.” , The print component of “Revolutionizing Cancer Care” is ... New York, Washington DC/Baltimore, and Seattle, with a circulation of approximately 250,000 copies ...
(Date:2/12/2016)... ... February 12, 2016 , ... Atlantic ... for Health Plans and PBMs,” an upcoming Feb. 24 webinar that will discuss ... in big-dollar therapeutic categories, such as the $1,000-per-pill hepatitis C treatment Sovaldi and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016  Governor Andrew M. Cuomo today announced a ... throughout Western New York . This ... Polytechnic Institute, includes a major expansion of Athenex,s North ... Buffalo , as well as the creation of ... Dunkirk . The combined projects are expected ...
(Date:2/11/2016)... , Feb. 11, 2016 AAIPharma ... provider of custom manufacturing and development services for ... sterile fill-finish capabilities and capacity in its ... in demand has driven several recent investments. ... it had one filling line with small-scale lyophilization. ...
(Date:2/11/2016)... -- Proliant Biologicals is proud to announce the opening of ... The facility is located on the North Island of ... Boone , Iowa.  The equipment design ... in the U.S. facility, with critical processing systems coming ... --> Boone , Iowa.  The ...
Breaking Medicine Technology: