Navigation Links
Chemo May Extend Survival After Breast Cancer's Return
Date:12/6/2012

THURSDAY, Dec. 6 (HealthDay News) -- In women with breast cancer that has recurred but remains confined to in or near the breast, post-surgical chemotherapy appears to boost survival, new research shows.

The study also found that patients with estrogen receptor (ER)-negative breast cancers -- tumors that are not reliant on estrogen -- were most responsive to this treatment.

It's well known that patients who experience a recurrence of local and/or regional (for example, nearby lymph nodes) breast cancer are at high risk for having their cancer spread to other areas of the body.

Some doctors administer chemotherapy to these patients after their recurrent breast tumors have been removed by surgery, but the efficacy of this treatment -- called adjuvant chemotherapy -- had not been studied until now.

"This is the first randomized controlled study that shows that adjuvant chemotherapy works in these patients," study author Dr. Stefan Aebi, head of the division of medical oncology at Luzerner Kantonsspital in Luzern, Switzerland, said in an American Association for Cancer Research news release.

The study was to be presented Thursday at the 2012 San Antonio Breast Cancer Symposium.

The study included 162 patients with isolated local and regional breast cancer recurrence: 85 received adjuvant chemotherapy and 77 did not.

According to the authors, five-year rates of disease-free survival (meaning the cancer did not return) were 69 percent in patients who got adjuvant chemotherapy compared to 57 percent for those who did not.

The overall survival rate was 88 percent for those who received adjuvant chemotherapy and 76 percent for those who did not.

Women with ER-negative breast cancer had the best results, with a five-year disease-free survival rate of 67 percent for those who received adjuvant chemotherapy and 35 percent for those who did not. Overall survival rates were 79 percent for those who received adjuvant chemotherapy and 69 percent for those who did not.

Among patients with ER-positive breast cancer (tumors that respond to estrogen), five-year, disease-free survival was 70 percent for those who received adjuvant chemotherapy and 69 percent for those who did not, the researchers said. Overall survival was 94 percent for those who received chemotherapy versus 80 percent among those who did not.

Although the study showed an association between adjuvant chemotherapy and improved survival, it did not prove a cause-and-effect link.

Two breast cancer experts were heartened by the results.

"There has been no clear way to manage locally recurrent breast cancer after excision -- most often, chemotherapy has been offered, but some patients have been hesitant about undergoing such aggressive therapy without known clear benefits," explained Dr. Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital in New York City.

Bernik said that, "It is exciting that we now have a randomized study that quantifies the benefit of chemotherapy for those with recurrent disease so that the patient can make an informed decision as to whether or not to go forward with the treatment. Clinicians now have a study to support what we have long held to be [that] chemotherapy can help improve survival even in woman with recurrent disease."

Dr. Kerin Adelson, an assistant professor of medicine at Mount Sinai School of Medicine, also in New York City, agreed.

"Local recurrences of breast cancer in breast tissue often near the site of the original cancer or in the axillary lymph nodes are curable, unlike cancer which returns in a distant organ," Adelson explained. "This [new] data is absolutely consistent with what we know about the benefit of systemic chemotherapy after a primary cancer. Going forward, oncologists should not hesitate to treat local recurrences as aggressively as they would a primary cancer."

More information

The U.S. National Cancer Institute has more about breast cancer treatment.

-- Robert Preidt

SOURCES: Stephanie Bernik, M.D., chief, surgical oncology, Lenox Hill Hospital, New York City; Kerin Adelson, M.D., assistant professor, medicine, Mount Sinai School of Medicine, New York City; American Association for Cancer Research, news release, Dec. 6, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
2. Improving chemotherapy effectiveness by acting on the immune system
3. Researchers identify physiological evidence of chemo brain
4. Nanomedicine breakthrough could improve chemotherapy for childhood cancer
5. Structure of enzyme unravelled providing basis for more accurate design of chemotherapeutic drugs
6. Researchers develop non-invasive technique for predicting patients response to chemotherapy
7. Stem Cell Therapy Reversed Chemo-Linked Infertility in Male Monkeys
8. Recent findings may help to fight melanomas resistance to chemotherapy
9. Key discovered to how chemotherapy drug causes heart failure
10. Many Terminal Cancer Patients Put False Hope in Chemo, Study Finds
11. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemo May Extend Survival After Breast Cancer's Return
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its line ... in Warner, New Hampshire at the MadgeTech headquarters. With products sold in more than ... by government agencies, including NASA. , In 2012, NASA strategically set up 17 ...
(Date:5/26/2016)... ... May 26, 2016 , ... Memorial Day Weekend marks ... Amica Insurance is sharing tips to make sure your family and vehicle are ... National Safety Council, there may be 439 deaths and an additional 50,500 serious injuries ...
(Date:5/26/2016)... ... May 26, 2016 , ... Nike Yoga Camps at ... daily practices, arts & crafts, discussions, and games all geared towards enhancing your ... have combined backgrounds in kids’ yoga, collegiate sport yoga instruction, and global yoga ...
(Date:5/26/2016)... ... May 26, 2016 , ... Bunion Bootie , the manufacturer ... treatment was more than humbled by customer demand over the Mother’s Day Weekend promotion. ... sale. Now that Bunion Bootie has completely replenished its inventory levels, it hopes to ...
(Date:5/26/2016)... ... May 26, 2016 , ... Workrite ... sales leadership and to further develop their rapidly expanding portfolio of customer and ... with a concentration in Marketing and an M.B.A. with concentration in management from ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 2016 A key trend that ... emergence of new treatments. Cardax, a development stage life ... The therapy is expected to fulfil large unmet medical ... conducting studies to develop new treatments for osteoarthritis. One ... involved in osteoarthritis are being investigated, and early trials ...
(Date:5/26/2016)... Since its commercial introduction in ... life science tool for conducting genetic studies in a ... in its new report that the industry sits on ... by a range of new applications in the clinical ... http://photos.prnewswire.com/prnh/20140723/694805 ) , Since the Human ...
(Date:5/25/2016)... HILDEN , Deutschland und GERMANTOWN, ... Zusammenarbeit mit Therawis bedient ... Entscheidungen bei Brustkrebs   QIAGEN N.V. ... QIA) gab heute bekannt, eine Lizenz- und Entwicklungsvereinbarung ... prädiktiver Assays für die Onkologie eingegangen zu sein. ...
Breaking Medicine Technology: