Navigation Links
Chemo May Extend Survival After Breast Cancer's Return
Date:12/6/2012

THURSDAY, Dec. 6 (HealthDay News) -- In women with breast cancer that has recurred but remains confined to in or near the breast, post-surgical chemotherapy appears to boost survival, new research shows.

The study also found that patients with estrogen receptor (ER)-negative breast cancers -- tumors that are not reliant on estrogen -- were most responsive to this treatment.

It's well known that patients who experience a recurrence of local and/or regional (for example, nearby lymph nodes) breast cancer are at high risk for having their cancer spread to other areas of the body.

Some doctors administer chemotherapy to these patients after their recurrent breast tumors have been removed by surgery, but the efficacy of this treatment -- called adjuvant chemotherapy -- had not been studied until now.

"This is the first randomized controlled study that shows that adjuvant chemotherapy works in these patients," study author Dr. Stefan Aebi, head of the division of medical oncology at Luzerner Kantonsspital in Luzern, Switzerland, said in an American Association for Cancer Research news release.

The study was to be presented Thursday at the 2012 San Antonio Breast Cancer Symposium.

The study included 162 patients with isolated local and regional breast cancer recurrence: 85 received adjuvant chemotherapy and 77 did not.

According to the authors, five-year rates of disease-free survival (meaning the cancer did not return) were 69 percent in patients who got adjuvant chemotherapy compared to 57 percent for those who did not.

The overall survival rate was 88 percent for those who received adjuvant chemotherapy and 76 percent for those who did not.

Women with ER-negative breast cancer had the best results, with a five-year disease-free survival rate of 67 percent for those who received adjuvant chemotherapy and 35 percent for those who did not. Overall survival rates were 79 percent for those who received adjuvant chemotherapy and 69 percent for those who did not.

Among patients with ER-positive breast cancer (tumors that respond to estrogen), five-year, disease-free survival was 70 percent for those who received adjuvant chemotherapy and 69 percent for those who did not, the researchers said. Overall survival was 94 percent for those who received chemotherapy versus 80 percent among those who did not.

Although the study showed an association between adjuvant chemotherapy and improved survival, it did not prove a cause-and-effect link.

Two breast cancer experts were heartened by the results.

"There has been no clear way to manage locally recurrent breast cancer after excision -- most often, chemotherapy has been offered, but some patients have been hesitant about undergoing such aggressive therapy without known clear benefits," explained Dr. Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital in New York City.

Bernik said that, "It is exciting that we now have a randomized study that quantifies the benefit of chemotherapy for those with recurrent disease so that the patient can make an informed decision as to whether or not to go forward with the treatment. Clinicians now have a study to support what we have long held to be [that] chemotherapy can help improve survival even in woman with recurrent disease."

Dr. Kerin Adelson, an assistant professor of medicine at Mount Sinai School of Medicine, also in New York City, agreed.

"Local recurrences of breast cancer in breast tissue often near the site of the original cancer or in the axillary lymph nodes are curable, unlike cancer which returns in a distant organ," Adelson explained. "This [new] data is absolutely consistent with what we know about the benefit of systemic chemotherapy after a primary cancer. Going forward, oncologists should not hesitate to treat local recurrences as aggressively as they would a primary cancer."

More information

The U.S. National Cancer Institute has more about breast cancer treatment.

-- Robert Preidt

SOURCES: Stephanie Bernik, M.D., chief, surgical oncology, Lenox Hill Hospital, New York City; Kerin Adelson, M.D., assistant professor, medicine, Mount Sinai School of Medicine, New York City; American Association for Cancer Research, news release, Dec. 6, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
2. Improving chemotherapy effectiveness by acting on the immune system
3. Researchers identify physiological evidence of chemo brain
4. Nanomedicine breakthrough could improve chemotherapy for childhood cancer
5. Structure of enzyme unravelled providing basis for more accurate design of chemotherapeutic drugs
6. Researchers develop non-invasive technique for predicting patients response to chemotherapy
7. Stem Cell Therapy Reversed Chemo-Linked Infertility in Male Monkeys
8. Recent findings may help to fight melanomas resistance to chemotherapy
9. Key discovered to how chemotherapy drug causes heart failure
10. Many Terminal Cancer Patients Put False Hope in Chemo, Study Finds
11. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemo May Extend Survival After Breast Cancer's Return
(Date:5/26/2017)... ... May 26, 2017 , ... Leading ... 2017 on May 30th and 31st at The Four Seasons Hotel Boston. ... in the life sciences, offering exclusive access to key decision makers who influence ...
(Date:5/26/2017)... ... May 26, 2017 , ... Amir Qureshi, MD is the first physician ... spinal cord stimulation system. The Nuvectra™ Algovita SCS System has been FDA approved as ... the first in Arkansas to introduce the most powerful SCS system and the only ...
(Date:5/26/2017)... ... ... A new analysis of community health data reveals that four out of the ... the average cost of healthcare rising and the U.S. senior population expected to double ... of where they live. An annual 2017 report looked at a variety of community ...
(Date:5/26/2017)... ... 26, 2017 , ... via seating is proud to partner ... chair specifically designed for clinical areas. Genie Copper Mesh is a crossover chair ... to provide customers with a game changing chair that is affordably priced,” Chas ...
(Date:5/26/2017)... ... May 26, 2017 , ... After raising nearly $30,000 on Kickstarter ... to be available at a discounted crowdfunding price on Indiegogo . , “Along ... I also wanted to bring a fidget toy to the market that was made ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)...  Semler Scientific, Inc. (OTCQB: SMLR), an emerging ... the clinical effectiveness and efficiency of healthcare providers, ... ended March 31, 2017. "We ... identify when preventive care options are appropriate, which ... attacks or strokes occur," said Doug Murphy-Chutorian ...
(Date:5/6/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), has begun a ... to its Welch Allyn campus. The ... more than 100 new jobs to Central ... a significant presence for more than 100 years. Hill-Rom,s ... large portion of which will be R&D and engineering ...
Breaking Medicine Technology: