Navigation Links
Chemo May Extend Survival After Breast Cancer's Return
Date:12/6/2012

THURSDAY, Dec. 6 (HealthDay News) -- In women with breast cancer that has recurred but remains confined to in or near the breast, post-surgical chemotherapy appears to boost survival, new research shows.

The study also found that patients with estrogen receptor (ER)-negative breast cancers -- tumors that are not reliant on estrogen -- were most responsive to this treatment.

It's well known that patients who experience a recurrence of local and/or regional (for example, nearby lymph nodes) breast cancer are at high risk for having their cancer spread to other areas of the body.

Some doctors administer chemotherapy to these patients after their recurrent breast tumors have been removed by surgery, but the efficacy of this treatment -- called adjuvant chemotherapy -- had not been studied until now.

"This is the first randomized controlled study that shows that adjuvant chemotherapy works in these patients," study author Dr. Stefan Aebi, head of the division of medical oncology at Luzerner Kantonsspital in Luzern, Switzerland, said in an American Association for Cancer Research news release.

The study was to be presented Thursday at the 2012 San Antonio Breast Cancer Symposium.

The study included 162 patients with isolated local and regional breast cancer recurrence: 85 received adjuvant chemotherapy and 77 did not.

According to the authors, five-year rates of disease-free survival (meaning the cancer did not return) were 69 percent in patients who got adjuvant chemotherapy compared to 57 percent for those who did not.

The overall survival rate was 88 percent for those who received adjuvant chemotherapy and 76 percent for those who did not.

Women with ER-negative breast cancer had the best results, with a five-year disease-free survival rate of 67 percent for those who received adjuvant chemotherapy and 35 percent for those who did not. Overall survival rates were 79 percent for those who received adjuvant chemotherapy and 69 percent for those who did not.

Among patients with ER-positive breast cancer (tumors that respond to estrogen), five-year, disease-free survival was 70 percent for those who received adjuvant chemotherapy and 69 percent for those who did not, the researchers said. Overall survival was 94 percent for those who received chemotherapy versus 80 percent among those who did not.

Although the study showed an association between adjuvant chemotherapy and improved survival, it did not prove a cause-and-effect link.

Two breast cancer experts were heartened by the results.

"There has been no clear way to manage locally recurrent breast cancer after excision -- most often, chemotherapy has been offered, but some patients have been hesitant about undergoing such aggressive therapy without known clear benefits," explained Dr. Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital in New York City.

Bernik said that, "It is exciting that we now have a randomized study that quantifies the benefit of chemotherapy for those with recurrent disease so that the patient can make an informed decision as to whether or not to go forward with the treatment. Clinicians now have a study to support what we have long held to be [that] chemotherapy can help improve survival even in woman with recurrent disease."

Dr. Kerin Adelson, an assistant professor of medicine at Mount Sinai School of Medicine, also in New York City, agreed.

"Local recurrences of breast cancer in breast tissue often near the site of the original cancer or in the axillary lymph nodes are curable, unlike cancer which returns in a distant organ," Adelson explained. "This [new] data is absolutely consistent with what we know about the benefit of systemic chemotherapy after a primary cancer. Going forward, oncologists should not hesitate to treat local recurrences as aggressively as they would a primary cancer."

More information

The U.S. National Cancer Institute has more about breast cancer treatment.

-- Robert Preidt

SOURCES: Stephanie Bernik, M.D., chief, surgical oncology, Lenox Hill Hospital, New York City; Kerin Adelson, M.D., assistant professor, medicine, Mount Sinai School of Medicine, New York City; American Association for Cancer Research, news release, Dec. 6, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
2. Improving chemotherapy effectiveness by acting on the immune system
3. Researchers identify physiological evidence of chemo brain
4. Nanomedicine breakthrough could improve chemotherapy for childhood cancer
5. Structure of enzyme unravelled providing basis for more accurate design of chemotherapeutic drugs
6. Researchers develop non-invasive technique for predicting patients response to chemotherapy
7. Stem Cell Therapy Reversed Chemo-Linked Infertility in Male Monkeys
8. Recent findings may help to fight melanomas resistance to chemotherapy
9. Key discovered to how chemotherapy drug causes heart failure
10. Many Terminal Cancer Patients Put False Hope in Chemo, Study Finds
11. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemo May Extend Survival After Breast Cancer's Return
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... The ... Day to recognize chaplains for their valuable support to patients and their families, and ... May 10. , To mark Spiritual Care Day, SCA has sent “Thank You Chaplain” ...
(Date:5/4/2016)... ... May 04, 2016 , ... All-Star Insurance ... to assist the people of their local community. The agency pledges to select ... leaders. Their hope is to bring awareness to important local causes with fundraising ...
(Date:5/4/2016)... ... May 04, 2016 , ... Momsense, Inc. ... mothers. The company’s patented technology, The Smart Breastfeeding Meter, is designed to monitor ... the technology is now available for purchase at Target.com . , ...
(Date:5/4/2016)... ... May 04, 2016 , ... Pharmacy Times ... that it was chosen as the Pharmaceutical News Provider of the Year in ... acknowledge the hard work and dedication of community members who strive to make ...
(Date:5/4/2016)... Sac, Wisconsin (PRWEB) , ... ... ... collection delivers next-level compression and support for knees, ankles, and elbows. Engineered ... value. , Innovative 3D flat-bed manufacturing (opposed to ineffective circular knitting, common ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... May 3, 2016  Specialty Silicone Fabricators is ... shows how a cleanroom works. The free visual ... science and technology. Chris ... technology company, SSF enthusiastically supports the Science, Technology, ... foster the next generation of innovators. We want ...
(Date:5/2/2016)... May 2, 2016 Kalorama Information noted the ... Records) market in a recent white paper.  The healthcare ... physician usage, a growing market are among the top ... Kalorama,s report EMR 2016: The Market for ... seventh complete study of the EMR industry, and the ...
(Date:5/2/2016)... , May 2, 2016 ... reach USD 11.1 billion by 2024, according to ... Inc. Major drivers of the sonography market include ... and government recommendations for periodic ultrasound screenings of ... (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) High ...
Breaking Medicine Technology: