Navigation Links
Chemo Drug Improves Stomach Cancer Survival for Japanese Patients
Date:10/31/2007

Researchers aren't sure if drug would have same benefit for Caucasians

WEDNESDAY, Oct. 31 (HealthDay News) -- Treatment of stomach cancer with an experimental chemotherapy drug after surgery improved survival rates for Japanese patients, a new study found.

The results of the trial won't mean much for Americans with stomach cancer, because the drug, designated S-1, is classified as "investigational" in the United States. But the study results could add impetus to the use of drug and/or radiation therapy against stomach cancer, U.S. experts said.

"This is the third large study that demonstrates a significant benefit of adjuvant (combination) therapy either before or after surgery for gastric cancer," said Dr. Manish Shah, an assistant attending oncologist at Memorial Sloan-Kettering Cancer Center in New York City.

Until relatively recently, it had generally been thought that drug or radiation therapy for stomach cancer wouldn't accomplish much, Shah said. "With less than one-year survival with metastatic disease, there may have been a sense that it didn't do any good," he said.

Metastatic means that the gastric cancer has spread outside the stomach, establishing microscopic colonies beyond the reach of surgery. But the almost 1,060 participants in the Japanese trial were potentially curable with surgery, because the disease had not spread. Half were assigned S-1 treatment plus surgery, while the other half had surgery followed by observation alone.

The trial, scheduled to last three years, was stopped after 12 months, because the survival rate for the S-1 group was 80.1 percent, compared to 70.1 percent for the surgery-only group.

The findings are published in the Nov. 1 issue of the New England Journal of Medicine.

S-1 had been used in some U.S. trials but was abandoned because of the high rate of side effects, Shah said. Japanese people apparently metabolize the drug differently than Caucasians, minimizing its side effects, he said.

Other drugs are being used successfully against stomach cancer, as is radiation, said Dr. Jaffer Ajani, professor of medicine at the University of Texas M.D. Anderson Cancer Center in Houston. But surgery is the essential first step in treatment of stomach cancer, he said.

"Chemotherapy alone has never been shown to be beneficial," Ajani said.

The U.S. National Cancer Institute estimates that there are 21,260 new cases of stomach cancer among Americans each year, with 11,210 deaths.

"Treatment for my patients includes radiation and chemotherapy together," Ajani said. "Not for every patient, but for most patients."

Use of such adjuvant therapy for stomach cancer began slowly, with studies showing that "chemotherapy was better than not for patients with metastatic disease," Shah said. Later trials showed benefits for people whose cancers had not spread.

"For gastric cancer, since 2001, some kind of adjuvant therapy has been given here in the United States, along with radiation," Shah said.

More information

Complete information on stomach cancer is available from the U.S. National Cancer Institute.



SOURCES: Manish Shah, M.D., assistant attending oncologist, Memorial Sloan-Kettering Cancer Center, New York City; Jaffer Ajani, M.D., professor of medicine, University of Texas M.D. Anderson Cancer Center, Houston; Nov. 1, 2007, New England Journal of Medicine


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Acupuncture May Help Chemotherapy Side Effects
2. Chemotherapy Pill Has Fewer Side Effects Than IV
3. Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy"
4. Response to chemotherapy could be measured by Prostate-Specific Antigen Doubling Time
5. Therapy Boosts Chemotherapy Effects
6. Chemotherapy Effective for Bladder Cancer
7. Hope for Chemo-Resistant Leukemia Patients
8. New Method Of Delivering Chemotherapy
9. Drug That Is Found To Reduce Heart Damage from Chemo
10. The Benefits Of Chemotherapy For Women With Ovarian Cancer
11. New Compound Could Strengthen The Effect Of Chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemo Drug Improves Stomach Cancer Survival for Japanese Patients
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg ... Legal Elite. The attorneys chosen by their peers for this recognition are considered among ... Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite Hall ...
(Date:6/24/2016)... Norcross, Georgia (PRWEB) , ... June 24, 2016 ... ... Year” awards today at the Clinical Decision Making in Emergency Medicine conference in ... who have authored journal articles published in Emergency Medicine Practice and ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 One of ... has announced the formation of a new biotechnology company, Noxopharm Limited ... $6m in an IPO and to list on the ASX. ... candidate, NOX66, ready to enter a Phase 1 clinical study later ... designed to address one of the biggest problems facing cancer patients ...
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/26/2016)... 2016  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) ... measures required to build a strong and stable market ... listed on the OTC Markets-pink current trading platform. ... "We are seeing an anomaly in market trading activities ... by the Company, but shareholders and market players as ...
Breaking Medicine Technology: