Navigation Links
Chemo Alone Effective in Treating Kids' Brain Tumors

Delaying, avoiding radiation could lessen long-term side effects, study finds

FRIDAY, Oct. 10 (HealthDay News) -- Using chemotherapy alone, and delaying or avoiding radiation altogether, may be effective in treating children with inoperable or progressive low-grade glioma brain tumors, according to a multi-institutional study.

Low-grade glioma is the most common brain tumor in children. If surgery can be performed, the survival rate for patients is 95 percent. But prognosis is worse for children with tumors in locations that prevent surgical removal or with tumors that progress after surgery, according to background information in a news release about the study from the University of Texas M.D. Anderson Cancer Center in Houston.

Radiation is often used to treat children with inoperable or progressive low-grade gliomas. While radiation is often effective in treating these brain tumors, it can cause long-term effects such as mental impairment, hormonal deficiencies and increased risk of stroke later in life.

This new phase III study compared two different chemotherapy regimens, and confirmed that chemotherapy can be used to control inoperable or progressive low-grade gliomas in children, said principal investigator Dr. Joann Ater, a professor of pediatrics at the Children's Cancer Hospital at M.D. Anderson.

The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent.

Patients aged 5 to 10 on the TPCV regimen averaged more than eight years without disease progression, compared to an average of 5.3 years among those who received the VC regimen. Patients younger than 5 on the VC regimen averaged 2.2 years before disease progression.

The study also found that chemotherapy was most effective among neurofibromatosis patients with low-grade gliomas.

"If we can delay radiation, then we allow more time for our youngest patients to develop physically, which could decrease some of the long-term effects from [radiation] treatment," Ater said. "This trial at least gives parents more information and alternative options when making decisions about their child's treatment."

The study was presented this week at the International Society of Pediatric Oncology annual meeting, in Berlin.

More information

The American Cancer Society has more about brain and spinal cord tumors in children.

-- Robert Preidt

SOURCE: M.D. Anderson Cancer Center, news release, Oct. 6, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pneumatosis cystoids intestinalis after fluorouracil chemotherapy
2. Anti-angiogenic drugs impede chemotherapy-stimulated tumor recovery
3. Erectile dysfunction drugs allowed more chemotherapy to reach brain tumors in laboratory study
4. CSHL scientists correlate enzyme expression levels with chemotherapy drug response
5. Medicare Modernization Act not associated with major changes in access to chemotherapy
6. Data Published in Anticancer Research Show ChemoFx(R) Assay Results Correlate With Outcomes in Breast Cancer
7. Solid tumor cells not killed by radiation and chemotherapy become stronger
8. Avastin Added to Chemo Helps Women With Advanced Breast Cancer
9. Erbitux Plus Chemo Improves Lung Cancer Outcomes
10. Avastin Added to Chemo Helps Women With Advanced Cancer
11. Chemo May Limit Fertility in Breast Cancer Survivors
Post Your Comments:
(Date:10/13/2017)... Ill. (PRWEB) , ... October ... ... Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer ... healthcare professionals on guideline updates for the primary prevention of cardiovascular diseases ...
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/12/2017)... Del. (PRWEB) , ... October 12, 2017 , ... ... and advisory services for healthcare compliance program management, will showcase a range of ... National Association for Assisted Living (NCAL) Convention and Expo to be held October ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
Breaking Medicine Technology: