Navigation Links
Chemist solves riddle of killer diseases

Anthrax, septicemia and meningitis are some of the planet's most deadly infections. In part because doctors lack basic insights to prevent and cure diseases caused by so called Gram-positive bacteria. Now, a chemist from the University of Copenhagen has revealed the mechanism behind these deadly infections.

By creating a synthetic version of a Gram-positive bacterial endotoxin, Danish synthetic chemist Christian Marcus Pedersen has made a contribution that'll compel immune biologists to revise their textbooks. More importantly, he has paved the first steps of the way towards new and effective types of antibiotics.

Chemist in international collaboration with biologists and physicians

The research results were attained in collaboration with Prof. Richard R. Schmidt of the University of Konstanz and biologists at the Leibniz-Zentrum fr Medizin und Biowissenschaften in Borstel, Germany. Ulrich Zhringer, leader of the Center in Borstel, is thrilled with Pedersen's achievement.

"No one knew what substance Gram-positive bacteria released to make us sick. But because Pedersen can supply us with substances that are entirely pure, and have a known structure and composition, we are able to get a more precise answer as to why we show symptoms when these bacteria enter our body," explains Professor Zhringer.

Synthesis succeeds where biologists gave up

Lipoteichoic acid, is a substance created and present in the cell wall of Gram positive bacteria. It appears to be the culprit of stimulating immune response symptoms such as fever, inflammation and organ failure. Indeed, when exploring illness, it is critical to investigate the substances that bind themselves to healthy human cells and thus, the cell wall becomes an important place to look. But if the substance breaks down as soon as it comes under the microscope, the chances of studying its binding abilities are not very great. Therefore, it was a major breakthrough when Pedersen was able to fabricate the molecule from scratch.

"Biologists have been trying to isolate this poison from living organisms for years. But the substance has a number of active groups. That is to say, the spiked parts of the molecule which enable the entire molecule to bind to cells. This makes it extremely difficult to purify. And dirty molecules are not conducive to viable research. Therefore, it's a great advantage to fabricate the substance synthetically, because we can "build" a molecule in which everything is included... Or where we ourselves decide which part of the structure to leave out," says Christian Marcus Pedersen.

Tiresome task but outstanding results

Lipoteichoic acid consists of 335 atoms combined in tangle, the complexity of which has made it difficult to collect. To create pure and intact molecules, Pedersen needed to complete 88 so-called synthesis steps. That is to say that 88 distinct "recipes", all of which needed to function, were required in order to reach the final result. These synthetic biomolecules are a fantastic tool for biologists in the investigation of Gram-positive bacteria's attack mechanisms.

"When it comes to these bacteria, there is still no one who knows precisely what on the bacteria activates the immune system. But we can build the precise parts of the structure that we want to. And biologists can examine how what we have built reacts with the immune system," says Pedersen.


Contact: Christian Marcus Pedersen
University of Copenhagen

Related medicine news :

1. Dalton Pharma Services and Boehringer Ingelheim (Canada) Ltd. Announce the Renewal of their Chemistry Services Agreement
2. Tastier MRE: Chemistry gives battlefield chow a gourmet flare
3. Subtyping breast cancer by immunohistochemistry to investigate survival terms
4. Basque researchers apply chemistry to restoration of paintings and dating of signatures
5. Pfizer joins open-access medicinal chemistry public-private collaboration
6. MIT moves toward greener chemistry
7. Biochemist studies DNA repair with $787,000 in grants
8. 2010 Chemistry Nobel laureate Ei-ichi Negishi leads C&EN webinar
9. MIT chemists engineer plants to produce new drugs
10. Medicinal chemist wins inaugural De Burgh Fellowship
11. UH biochemist works to revolutionize ovarian cancer treatment
Post Your Comments:
Related Image:
Chemist solves riddle of killer diseases
(Date:11/24/2015)... ... November 24, 2015 , ... DMG Productions announced that they will feature ... quarter 2016 via Discovery Channel. Dates and show times TBA. , Aphria, Inc., is ... the business of producing and supplying medical marijuana pursuant to the Marijuana for Medical ...
(Date:11/24/2015)... Church, VA (PRWEB) , ... November 24, 2015 , ... ... — 1:30 p.m. – 3:00 p.m. EST, , FDA has long ... regulations. CLIA regulations apply to performing the tests and do not meet the device ...
(Date:11/24/2015)... ... 2015 , ... The Trustees, Massachusetts’ largest conservation and preservation ... at several of their most popular properties, including Crane Beach in Ipswich, World’s ... Black Friday #OptOutside Campaign. The Trustees encourage families and friends to take the ...
(Date:11/24/2015)... ... November 24, 2015 , ... In response to recent news highlighting ... from prescription opioids in the United States grew 400 percent between 1999 and 2010, ... were involved in 37 percent of all fatal drug overdoses. (1) , While oxycodone ...
(Date:11/24/2015)... N.J. (PRWEB) , ... November 24, 2015 , ... ... will gather to share their knowledge and experiences at a live taping of ... the Ruesch Center for the Cure of Gastrointestinal Cancers 2015 Symposium at Georgetown ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 24. November 2015 Avery Biomedical ... Systems, ist erfreut, die Berufung von Anders ... geben zu können. ... --> Foto -   ... Von 1984-1986 war er Fellow des Cardiovascular ...
(Date:11/24/2015)... India , November 24, 2015 ... market research report "Spine Biologics Market by Product Type (Bone ... (Anterior Cervical Discectomy and Fusion, Posterior Lumbar Interbody Fusion), End ... MarketsandMarkets, the global market was valued at $1.90 Billion in ... at a CAGR of 4.4% during the forecast period of ...
(Date:11/24/2015)... Nov. 24, 2015 Avery Biomedical Devices (ABD), ... to announce the appointment of Anders Jonzon , ... Dr. Jonzon is a ... Children,s Hospital, Uppsala University, Uppsala and Children,s Hospital, Karolinska, ... was a fellow at the Cardiovascular Institute (UCSF). His ...
Breaking Medicine Technology: