Navigation Links
Chemist solves riddle of killer diseases
Date:6/23/2011

Anthrax, septicemia and meningitis are some of the planet's most deadly infections. In part because doctors lack basic insights to prevent and cure diseases caused by so called Gram-positive bacteria. Now, a chemist from the University of Copenhagen has revealed the mechanism behind these deadly infections.

By creating a synthetic version of a Gram-positive bacterial endotoxin, Danish synthetic chemist Christian Marcus Pedersen has made a contribution that'll compel immune biologists to revise their textbooks. More importantly, he has paved the first steps of the way towards new and effective types of antibiotics.

Chemist in international collaboration with biologists and physicians

The research results were attained in collaboration with Prof. Richard R. Schmidt of the University of Konstanz and biologists at the Leibniz-Zentrum fr Medizin und Biowissenschaften in Borstel, Germany. Ulrich Zhringer, leader of the Center in Borstel, is thrilled with Pedersen's achievement.

"No one knew what substance Gram-positive bacteria released to make us sick. But because Pedersen can supply us with substances that are entirely pure, and have a known structure and composition, we are able to get a more precise answer as to why we show symptoms when these bacteria enter our body," explains Professor Zhringer.

Synthesis succeeds where biologists gave up

Lipoteichoic acid, is a substance created and present in the cell wall of Gram positive bacteria. It appears to be the culprit of stimulating immune response symptoms such as fever, inflammation and organ failure. Indeed, when exploring illness, it is critical to investigate the substances that bind themselves to healthy human cells and thus, the cell wall becomes an important place to look. But if the substance breaks down as soon as it comes under the microscope, the chances of studying its binding abilities are not very great. Therefore, it was a major breakthrough when Pedersen was able to fabricate the molecule from scratch.

"Biologists have been trying to isolate this poison from living organisms for years. But the substance has a number of active groups. That is to say, the spiked parts of the molecule which enable the entire molecule to bind to cells. This makes it extremely difficult to purify. And dirty molecules are not conducive to viable research. Therefore, it's a great advantage to fabricate the substance synthetically, because we can "build" a molecule in which everything is included... Or where we ourselves decide which part of the structure to leave out," says Christian Marcus Pedersen.

Tiresome task but outstanding results

Lipoteichoic acid consists of 335 atoms combined in tangle, the complexity of which has made it difficult to collect. To create pure and intact molecules, Pedersen needed to complete 88 so-called synthesis steps. That is to say that 88 distinct "recipes", all of which needed to function, were required in order to reach the final result. These synthetic biomolecules are a fantastic tool for biologists in the investigation of Gram-positive bacteria's attack mechanisms.

"When it comes to these bacteria, there is still no one who knows precisely what on the bacteria activates the immune system. But we can build the precise parts of the structure that we want to. And biologists can examine how what we have built reacts with the immune system," says Pedersen.


'/>"/>

Contact: Christian Marcus Pedersen
cmp@chem.ku.dk
453-532-0190
University of Copenhagen
Source:Eurekalert  

Related medicine news :

1. Dalton Pharma Services and Boehringer Ingelheim (Canada) Ltd. Announce the Renewal of their Chemistry Services Agreement
2. Tastier MRE: Chemistry gives battlefield chow a gourmet flare
3. Subtyping breast cancer by immunohistochemistry to investigate survival terms
4. Basque researchers apply chemistry to restoration of paintings and dating of signatures
5. Pfizer joins open-access medicinal chemistry public-private collaboration
6. MIT moves toward greener chemistry
7. Biochemist studies DNA repair with $787,000 in grants
8. 2010 Chemistry Nobel laureate Ei-ichi Negishi leads C&EN webinar
9. MIT chemists engineer plants to produce new drugs
10. Medicinal chemist wins inaugural De Burgh Fellowship
11. UH biochemist works to revolutionize ovarian cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemist solves riddle of killer diseases
(Date:2/8/2016)... ... February 08, 2016 , ... Remember the old saying “rub some ... to Perry A~, author of “Calcium Bentonite Clay” the health benefits of integrating clay ... and detoxifying the body. , A former motivational speaker, Perry A~ has since dedicated ...
(Date:2/8/2016)... ... 2016 , ... Discover the Rocky Mountain region’s longest running and impressive garden ... Attendees also get to see the most incredible gardens and home improvement experts that ... the Colorado Convention Center - 700 14th St. Denver CO, is an exciting event ...
(Date:2/8/2016)... ... February 08, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Moles are derived from a cluster of melanin when exposed to sunlight. Although most ... create a lifetime of embarrassment. Historically, mole removal has involved a painful, ...
(Date:2/8/2016)... CA (PRWEB) , ... February 08, 2016 , ... The ... held annually in this country. The AutismOne 2016 Conference, which is being held May ... they often won’t hear elsewhere about helpful interventions and causes of chronic illness in ...
(Date:2/7/2016)... Orion, Clarkston, Metamora, Michigan (PRWEB) , ... February 07, 2016 , ... ... Friday in recognition of National Wear Red Day. National Wear Red Day is ... and stroke in women. Heart disease and stroke cause 1 in 3 deaths among ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  Avista Pharma Solutions ... Eric Setzer as Chief Financial Officer (CFO). Mr. Setzer ... years of experience in various roles within growing technology ... he served as the Executive Director of Finance at ... Raleigh, NC . Previously, Mr. Setzer ...
(Date:2/8/2016)... DUBLIN , Feb. 8, 2016 /PRNewswire/ ... announced the addition of the "Label-Free ... Global Forecasts to 2020" report to ... has announced the addition of the ... - Global Forecasts to 2020" report ...
(Date:2/8/2016)... , Feb. 8, 2016  Unilife Corporation ("Unilife" or "Company") ... of injectable drug delivery systems, today announced that it will ... ended December 31, 2015 after market close on February 9, ... conference call to discuss these financial results.    ... --> About Unilife Corporation ...
Breaking Medicine Technology: