Navigation Links
Chemical tags likely to affect metabolism, cancer development
Date:2/18/2010

y a role in the other half of the cell, the cytoplasm.

So they separated the nucleus and the cytoplasm of primary liver cells, and then took a chemical census of the cytoplasm's contents using a technology called mass spectroscopy. They identified approximately a thousand new proteins that are acetylated, greatly expanding the previously recognized repertoire of fifty.

At first, the researchers were overwhelmed by such a large number of proteins to study, said Xiong. But then they began notice a pattern -- almost every metabolic enzyme was acetylated, presumably because their starting material was liver, an organ rich in metabolic activity.

"We think that acetylation is likely to play a very extensive role in regulation of many different cellular processes, not just metabolism," said Xiong.

Xiong and his colleagues looked at the acetylation of one enzyme from each of the four major metabolic pathways. They found that by altering the metabolic fuels that feed into these pathways they could alter the level of acetylation.

In addition, the researchers discovered that blocking acetylation chemically or genetically affected these metabolic enzymes in a number of different ways, either by stimulating its activity, inhibiting it, or degrading the protein itself. They suspect that acetylation is important for coordinating not only the players within a metabolic pathway but also between different pathways.

The next step is to take their finding in normal cells and see how it can inform their study of tumor cells. The researchers are in the process of looking at each metabolic enzyme, one-by-one, to see which one displays the most disparate acetylation patterns between normal and cancer cells. They will then try to use the very same proteins that tack on or pull off those acetyl groups called acetylases or deacetylases, respectively -- to modify acetylation and thwart cancer development.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Chemical culprit in popcorn workers lung identified
2. American Chemical Societys Weekly Presspac -- Sept. 5, 2007
3. Rohm and Haas to Webcast Presentation at Credit Suisse Chemicals Conference
4. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
5. Low Doses of Red Wine Chemical May Fight Diabetes
6. National Academies advisory: genes and toxic chemicals
7. Genomic technologies to identify toxic chemicals should be developed
8. Malaria No More and Sumitomo Chemical Help Protect 1.4 Million Kids from Malaria
9. American Chemical Societys Weekly Presspac -- Oct. 17, 2007
10. Researchers study potential health benefits of natural chemicals in muscadine grape seeds
11. Brains Reward Chemical May Help Spur Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemical tags likely to affect metabolism, cancer development
(Date:3/27/2015)... UK (PRWEB) March 27, 2015 DrugDev ... Melissa (Liss) Easy was named to the 2015 Philadelphia ... Under 40 list spotlights 40 dynamic, up-and-coming leaders less ... and community involvement. Winners are honored at an awards ... of the Philadelphia Business Journal. , Lyn Kremer, Publisher ...
(Date:3/27/2015)... Naples, FL and London, UK (PRWEB) March 27, 2015 ... solution, announced today that it has appointed Sean Fitzgerald, ... the role of Chief Operating Officer and Interim Chief ... Vice President of leading education technology innovator, EverFi, backed ... Eric Schmidt, and Twitter founder Evan Williams. Prior to ...
(Date:3/27/2015)... Operatic contenders and their avid audience ... 17th. The universally acclaimed baritone Sherrill Milnes will be ... Idol at The Merion in Evanston. The event is ... aspiring opera singers from around the country. “This is ... finest young talent in the country,” said Margaret Gergen, ...
(Date:3/27/2015)... March 27, 2015 Since September 2014, the ... his comeback tour after having been in retirement for a ... for the performer to return to touring, and concert events ... for Omaha will likely sell out for the two shows ... BuyCheapTicketsToEvents.com to view the inventory of discounted Garth Brooks ...
(Date:3/27/2015)... “ VXi BlueParott Reveal ” was featured on ... features the latest and coolest technology products available to ... for NewsWatch, conducted the review and shared with viewers ... of ambient noise. , Today, business is all about ... to any professional, voice calls are just as important. ...
Breaking Medicine News(10 mins):Health News:DrugDev Founder Melissa Easy is 2015 Philadelphia Business Journal 40 Under 40 Honoree 2Health News:GenSight Appoints Former Technology Executive as Chief Operating Officer 2Health News:Opera Idol Competition At The Merion In Evanston 2Health News:Garth Brooks Tickets for Omaha: BuyCheapTicketsToEvents.com Draws Customers by Discounting Prices on 2015 Tickets for Garth Brooks’ Tour Stops at CenturyLink Center 2Health News:A Device to Tune out Background Noise was Recently Featured on NewsWatch Television 2
... thrombosis, study says , MONDAY, July 20 (HealthDay News) ... or varicose veins that have become swollen and painful ... problem. , One-quarter of patients with superficial vein thrombosis ... thrombosis (DVT), a potentially life-threatening condition. , "The diagnosis ...
... foods, experts advise reading food labels , MONDAY, July 20 ... to hypertension, but it can also reduce the effectiveness of ... striking about these results is the degree of the effect," ... the University of Alabama at Birmingham, and a member of ...
... , , LOS ... announced that Caroline W. Nahas, managing director of the Southern California ... chair of the organization,s corporate board of directors. The appointment of ... important role. Nahas will replace outgoing board chair, Jeffrey M. Johnson, ...
... is one of only four sites across the country to ... The study will investigate the effectiveness of a chemotherapeutic agent, ... heat therapy) for treating recurrent chest wall breast cancer. ... of breast cancer on the chest wall, most commonly presenting ...
... ... Sports Week, parents asked to share their experiences and tips on keeping kids healthy and ... Minneapolis, ... are tossing video games and television aside as they enjoy the summer sun. While the ...
... , , NAPERVILLE, Ill., July ... (IHA) announced today that Maryjane A. Wurth, 53, Chief Operating Officer, ... the new president of IHA. Wurth succeeds Ken Robbins, who has ... year. She will assume her duties as IHA,s president in October. ...
Cached Medicine News:Health News:Vein Condition May Mask Serious Clot Disorder 2Health News:High-Salt Diet Dampens Effects of Blood Pressure Drugs 2Health News:High-Salt Diet Dampens Effects of Blood Pressure Drugs 3Health News:Caroline W. Nahas Named New Corporate Board Chair for United Way of Greater Los Angeles 2Health News:Caroline W. Nahas Named New Corporate Board Chair for United Way of Greater Los Angeles 3Health News:RI Hospital first in country to enroll patient in new study for recurrent chest wall breast cancer 2Health News:Treating Kids' Summertime Bumps, Bruises and Injuries with The Healthcare Scoop 2Health News:Treating Kids' Summertime Bumps, Bruises and Injuries with The Healthcare Scoop 3Health News:Maryjane A. Wurth Named New President of Illinois Hospital Association 2
(Date:3/27/2015)... Biopharmaceutical Industry Leads Manufacturing Sector in R&D Spending ... as the country,s manufacturing leader in innovation and economic ... to the  analysis , the industry had the highest ... accounting for 27 percent of average annual R&D spending ... on Medicare Part D - Medicare Part D ...
(Date:3/27/2015)... , March 27, 2015 A new report from ... America – Chile , ... are top targets for IVD firms.  The healthcare research firm ... into IVD strategies for the Latin American continent with a ... globally distributed supply operations. However, the country,s regional economic clout ...
(Date:3/27/2015)... , March 27, 2015 ... International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare, ... senior service industry, will be held at Shanghai New ... On 25 February, 2015,  Implementation Suggestions on Encouraging Private ... Industry, which was jointly issued by the Ministry of ...
Breaking Medicine Technology:Week in Review: The Latest from PhRMA 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 3Kalorama: Beyond Brazil, Latin American IVD Market Grows 4CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 2CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 3CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 4CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 5CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 6
... (telmisartan) against placebo, in reducing ... infarction, stroke and hospitalization for congestive heart ... receiving current standard of care, RIDGEFIELD, ... of the,TRANSCEND(TM)* trial demonstrated that treatment with ...
... Seven Korean medical centers to collaborate on studies of ... role of cell-mediated immunity, COLUMBIA, Md., Aug. 28 ... Woo Biotech, is delighted to be able to,announce our ... assay,for cell-mediated immunity at seven highly respected medical institutions,in ...
Cached Medicine Technology:TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 2TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 3TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 4TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 5TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 6TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet 7Cylex Announces Plan for Multi-Center Trial of ImmuKnow(R) Assay in South Korea 2Cylex Announces Plan for Multi-Center Trial of ImmuKnow(R) Assay in South Korea 3
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
This dissector offers dual-action jaws, which are long, tapered, and angled 30 to simplify even difficult laparoscopic dissection....
The Optima III 45 cm line of laparoscopic hand instruments is ideal for operative laparoscopic/endoscopic procedures or when a longer instrument is needed....
Medicine Products: