Navigation Links
Chemical tags likely to affect metabolism, cancer development
Date:2/18/2010

y a role in the other half of the cell, the cytoplasm.

So they separated the nucleus and the cytoplasm of primary liver cells, and then took a chemical census of the cytoplasm's contents using a technology called mass spectroscopy. They identified approximately a thousand new proteins that are acetylated, greatly expanding the previously recognized repertoire of fifty.

At first, the researchers were overwhelmed by such a large number of proteins to study, said Xiong. But then they began notice a pattern -- almost every metabolic enzyme was acetylated, presumably because their starting material was liver, an organ rich in metabolic activity.

"We think that acetylation is likely to play a very extensive role in regulation of many different cellular processes, not just metabolism," said Xiong.

Xiong and his colleagues looked at the acetylation of one enzyme from each of the four major metabolic pathways. They found that by altering the metabolic fuels that feed into these pathways they could alter the level of acetylation.

In addition, the researchers discovered that blocking acetylation chemically or genetically affected these metabolic enzymes in a number of different ways, either by stimulating its activity, inhibiting it, or degrading the protein itself. They suspect that acetylation is important for coordinating not only the players within a metabolic pathway but also between different pathways.

The next step is to take their finding in normal cells and see how it can inform their study of tumor cells. The researchers are in the process of looking at each metabolic enzyme, one-by-one, to see which one displays the most disparate acetylation patterns between normal and cancer cells. They will then try to use the very same proteins that tack on or pull off those acetyl groups called acetylases or deacetylases, respectively -- to modify acetylation and thwart cancer development.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Chemical culprit in popcorn workers lung identified
2. American Chemical Societys Weekly Presspac -- Sept. 5, 2007
3. Rohm and Haas to Webcast Presentation at Credit Suisse Chemicals Conference
4. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
5. Low Doses of Red Wine Chemical May Fight Diabetes
6. National Academies advisory: genes and toxic chemicals
7. Genomic technologies to identify toxic chemicals should be developed
8. Malaria No More and Sumitomo Chemical Help Protect 1.4 Million Kids from Malaria
9. American Chemical Societys Weekly Presspac -- Oct. 17, 2007
10. Researchers study potential health benefits of natural chemicals in muscadine grape seeds
11. Brains Reward Chemical May Help Spur Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemical tags likely to affect metabolism, cancer development
(Date:12/15/2014)... Veretekk.com, Inc. announced today a strategic alliance ... Ocean Avenue has secured exclusive benefit to the strategic ... JM Ocean Avenue is a direct sales company ... and JM International, with partial ownership coming from JM ... , “After nearly 2 decades of servicing the industry ...
(Date:12/15/2014)... South Florida’s leading urgent care provider, MD ... daze of hassle, hustle, and bustle that can cause injuries ... burns when making special meals and heartburn after eating them, ... any time. To prevent this season of joy from becoming ... of helpful and healthful holiday tips to keep the season ...
(Date:12/15/2014)... Beltsville, MD (PRWEB) December 15, 2014 ... and services today released “ Social Media Cheat Sheets ... cultivating a community that drives results on the top ... a marketing program. It helps drive awareness, engagement, and ... conversions. For marketers to make an impact on new ...
(Date:12/15/2014)... Reinberg HealthDay Reporter FRIDAY, ... should reassure the millions of American women who have migraine: ... "There is no association between migraine and breast cancer ... medicine at Harvard Medical School. "There is no positive association, ... no protective effect either." About 18 percent of American ...
(Date:12/15/2014)... December 15, 2014 The increase in prevalence ... of the main factors which is contributing to the growth ... the diagnosis and treatment of hearing loss and balance disorders ... three parts - microphone, speaker and amplifier. The global market ... of 6.01% during the period from 2014 to 2019. Some ...
Breaking Medicine News(10 mins):Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 2Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 4Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 2Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 3Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 2Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 3Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 4
... , Anti-Abortion Extremist Ejected After "Murder" ... night in northern Virginia, Representative James Moran and Governor Howard Dean ... by thousands of people. Anti-abortion extremist Randall Terry, the founder of ... be there to disrupt it by accusing President Obama of "killing ...
... million acres in the southeastern United States, may sprout into ... the first evidence that root extracts from kudzu show promise ... metabolic syndrome that affects almost 50 million people in ... issue of ACS, Journal of Agricultural and Food Chemistry ...
... BATESVILLE, Ind., Aug. 26 Hill-Rom Holdings, Inc., (NYSE: HRC ) ... CEO, Hill-Rom, at the Thomas Weisel Partners Healthcare Conference in Boston on Thursday, ... , You are invited to listen to the live discussion via ... or access it directly at http://www.ver a ...
... , , , ... PRA International, a leading Clinical Research Organization, will host ... region in global clinical research studies. In this audio conference, ... discuss the benefits and challenges of managing clinical trials in ...
... , MORRIS PLAINS, N.J., Aug. 26 New entries ... care of their eyes. , , "Eye ... of several factors including indoor and outdoor irritants and allergens like dust, ... process," says Elise Brisco, O.D. "Since many people experience more ...
... , , , ... PPHM ) today announced that the U.S. National ... two-year, $763,000 grant to Philip Thorpe, Ph.D., of the University ... of anti-phosphatidylserine (anti-PS) antibodies as potential treatments for viral hemorrhagic ...
Cached Medicine News:Health News:Randall Terry Removed By Police From Howard Dean Health Care Town Hall Meeting 2Health News:Hill-Rom to Participate at the Thomas Weisel Partners 2009 Healthcare Conference 2Health News:PRA International to Host Audio Conference 2Health News:Breakthroughs in Eye Care Products Offer Fresh Approach for Soothing Eyes 2Health News:NIAID Awards New Grant to Expand Studies of Peregrine's Anti-PS Antibodies to Treat Viral Hemorrhagic Fevers 2Health News:NIAID Awards New Grant to Expand Studies of Peregrine's Anti-PS Antibodies to Treat Viral Hemorrhagic Fevers 3Health News:NIAID Awards New Grant to Expand Studies of Peregrine's Anti-PS Antibodies to Treat Viral Hemorrhagic Fevers 4Health News:NIAID Awards New Grant to Expand Studies of Peregrine's Anti-PS Antibodies to Treat Viral Hemorrhagic Fevers 5
(Date:12/17/2014)... 17, 2014  Beamz Interactive, Inc. (OTCQB: BZIC), ... today announced that it has signed an agreement ... supplier of innovative prosthetic, orthotic and assistive technology ... the agreement, RSL Steeper will promote and supply ... for use within UK residential care facilities through ...
(Date:12/17/2014)... 2014  RXi Pharmaceuticals Corporation (NASDAQ: ... developing and commercializing innovative therapies addressing major unmet ... enrollment in its first Phase 2a study, RXI-109-1301.  ... the 1-month findings that were reported in September ... http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , , , ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and ... the addition of the "MEMS Gyroscopes Analog ... Analysis" report to their offering. ... gyroscopes for tactical grade applications made a lot ... term of reliability. They are now accepted in ...
Breaking Medicine Technology:Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular Rate Sensor Reverse Costing Analysis 2
... trauma surgeon at Brooke Army Medical Center in San Antonio, ... announcement on April 28, 2011, that the U.S. Food and ... its CARDIOHELP System in the United States as a cardiac ... "The ability to bring environmental control and life ...
... Sciences, Inc., (GT) a privately held biotechnology company announced ... AND METHODS FOR CONSTRUCTING GENOMIC-BASED PHENOTYPIC MODELS" by the ... has a priority date of June 14, 2002 and ... modeling processes by which scientists may use computational models ...
Cached Medicine Technology:GT Life Sciences Broadens Intellectual Property Portfolio with Issuance of U.S. Patent on Core Computational Systems and Methods for Genomic-based Metabolic Modeling 2GT Life Sciences Broadens Intellectual Property Portfolio with Issuance of U.S. Patent on Core Computational Systems and Methods for Genomic-based Metabolic Modeling 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: