Navigation Links
Chemical tags likely to affect metabolism, cancer development
Date:2/18/2010

y a role in the other half of the cell, the cytoplasm.

So they separated the nucleus and the cytoplasm of primary liver cells, and then took a chemical census of the cytoplasm's contents using a technology called mass spectroscopy. They identified approximately a thousand new proteins that are acetylated, greatly expanding the previously recognized repertoire of fifty.

At first, the researchers were overwhelmed by such a large number of proteins to study, said Xiong. But then they began notice a pattern -- almost every metabolic enzyme was acetylated, presumably because their starting material was liver, an organ rich in metabolic activity.

"We think that acetylation is likely to play a very extensive role in regulation of many different cellular processes, not just metabolism," said Xiong.

Xiong and his colleagues looked at the acetylation of one enzyme from each of the four major metabolic pathways. They found that by altering the metabolic fuels that feed into these pathways they could alter the level of acetylation.

In addition, the researchers discovered that blocking acetylation chemically or genetically affected these metabolic enzymes in a number of different ways, either by stimulating its activity, inhibiting it, or degrading the protein itself. They suspect that acetylation is important for coordinating not only the players within a metabolic pathway but also between different pathways.

The next step is to take their finding in normal cells and see how it can inform their study of tumor cells. The researchers are in the process of looking at each metabolic enzyme, one-by-one, to see which one displays the most disparate acetylation patterns between normal and cancer cells. They will then try to use the very same proteins that tack on or pull off those acetyl groups called acetylases or deacetylases, respectively -- to modify acetylation and thwart cancer development.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Chemical culprit in popcorn workers lung identified
2. American Chemical Societys Weekly Presspac -- Sept. 5, 2007
3. Rohm and Haas to Webcast Presentation at Credit Suisse Chemicals Conference
4. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
5. Low Doses of Red Wine Chemical May Fight Diabetes
6. National Academies advisory: genes and toxic chemicals
7. Genomic technologies to identify toxic chemicals should be developed
8. Malaria No More and Sumitomo Chemical Help Protect 1.4 Million Kids from Malaria
9. American Chemical Societys Weekly Presspac -- Oct. 17, 2007
10. Researchers study potential health benefits of natural chemicals in muscadine grape seeds
11. Brains Reward Chemical May Help Spur Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemical tags likely to affect metabolism, cancer development
(Date:10/22/2014)... (PRWEB) October 22, 2014 Losing Weight Your ... industry is staring you in the face, it certainly can ... not do your body an extra favor by doing it ... tempting crash diets. Instead, listen to your body, exercise regularly, ... Exercise is essential to losing weight; you need to exercise ...
(Date:10/22/2014)... Steven Reinberg HealthDay ... Infants who quickly add weight and length may be showing ... suggests. In adults, certain genes have been linked to ... proportionate gains in fat and lean muscle, the researchers said. ... heavier and taller. By ages 2 and 3, however, these ...
(Date:10/22/2014)... taken by Firestone officials at the company,s rubber ... spread of the disease there and could prove effective ... provides health services to about 80,000 employees, retirees, their ... Between Aug. 1 and Sept. 23, there were 71 ... That incidence rate of 0.09 percent was much lower ...
(Date:10/20/2014)... Pittsburgh, PA (PRWEB) October 20, 2014 ... new, minimally-invasive procedure that enables physicians to repair a ... , The MitraClip system, developed by ... regurgitation (MR), a progressive and life-threatening condition in which ... allowing blood to flow backward from the heart’s left ...
(Date:10/20/2014)... hc1.com today announced the launch of ... enables healthcare organizations of all sizes to immediately ... management (“CRM”) solution. , Designed from the ground ... healthcare industry, the hc1 Healthcare Relationship Cloud™ personalizes ... combining healthcare CRM, HIPAA-compliant collaboration, and real-time analytics ...
Breaking Medicine News(10 mins):Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2
... rise of the central nervous system [CNS] in animal ... worms evolved// from the same ancestor, but their CNSs ... after their lineages had split during evolution. Researchers from ... reveal that the vertebrate nervous system is probably much ...
... need to pull up its socks on health issues, lest ... leader of chronic diseases’. If the present trend continues//, 66% ... ,A study conducted by Assocham and Price ... has shown the vulnerability of the Indian population to cardiovascular ...
... focused on motivating seniors and others with Medicare to make ... the U.S. Department of Health and Human Services (HHS) and ... is titled: A Healthier US Starts Here. , ... and summer, the Medicare Prevention tour bus will visit each ...
... U.S. Food and Drug Administration (FDA) is alerting health ... broadcasts that provide emerging// drug safety information. The broadcasts, ... computers and personal audio players. ,The service ... and speed its communications concerning the safety of ...
... modern lifestyle, which puts people under constant stress, could ... kidney disease// and dementia, scientists have warned. ... eating a poor diet, drinking too much alcohol and ... of developing heart problems. ,For some people, ...
... A peptide found in human blood inhibited 60 strains ... to a study published Thursday in the journal Cell//, ... can inhibit HIV strains that have developed resistance to ... development of new HIV/AIDS drugs -- the Chronicle reports. ...
Cached Medicine News:Health News:The Origin of the Brain Lies in a Worm 2Health News:Seniors Encouraged To Make Use Of Medicare’s Freebie 2Health News:FDA Announces Audio Broadcasts on Emerging Drug Safety Information 2Health News:Modern Lifestyle Could Damage Heart 2Health News:Peptide Found in Human Blood Inhibits 60 Strains of HIV, Study Says 2
(Date:10/22/2014)... FRANCISCO , Oct. 22, 2014 Moms ... and health trackers for themselves and their kids, according ... 2014 Report: Health & Fitness Go Mobile for Moms, ... Insights Series. BabyCenter, the number 1 pregnancy and parenting ... found that 55 percent of moms surveyed say they ...
(Date:10/22/2014)... Oct. 22, 2014  With a vision to ... medications, a Global Pharmaceutical and Biotech manufacturer selects ... and turnkey solution to protect their animal health ... Photo - http://photos.prnewswire.com/prnh/20141021/153439 ... serialized and aggregated by the Xyntek and Antares ...
(Date:10/22/2014)... Influenza will affect as many as 200,000 people ... United States as high as 49,000 people.  The ... from person to person in respiratory droplets of coughs and ... death, but kills much fewer people each year than the ... fluids including sweat, saliva, blood and other bodily fluids. The ...
Breaking Medicine Technology:BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4Xyntek and Antares Serialization Solution Protects Pets Too! 2WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2
Visionary OFFICE™ PM offers a Windows interface featuring medical billing, appointment scheduling and patient information....
... Medical Billing system allows a practice ... It is integrated with the EMR, ... system interfaces with electronic clearinghouses for ... a set of reports, it presents ...
... Amylase CPNG3 single liquid stable reagent ... of single liquid stability to help ... and provide quick result turnaround time. ... Amylase CPNG3 reagent provides a long ...
... The Infinity Uric Acid single liquid ... the convenience of single liquid stability ... operator error and provide quick result ... the Infinity Uric Acid reagent provides ...
Medicine Products: