Navigation Links
Chemical strategy hints at better drugs for osteoporosis, diabetes
Date:6/16/2014

ach seems to suggest a general strategy to retain the ability to target a specific receptor while diminishing the action of degrading enzymes. The key is that the receptor is looking for one shape while the destructive enzyme seeks a different shape."

Gellman says the idea of replacing segments of the peptide backbone with artificial units once seemed heretical. "Most people expected that you could not change the backbone, which alters the spacing and orientation of the essential contact points, without making the molecule unrecognizable to the receptor."

Gellman has assigned his rights for the discovery to the Wisconsin Alumni Research Foundation. The study's first author, Cheloha, is a Ph.D. candidate in chemistry at UW-Madison. Co-author Thomas J. Gardella led a team at Harvard Medical School that conducted the biological assessments.

Potentially, the "alter-the-backbone" strategy could allow oral dosing of the rather fragile peptide drugs, which today must be injected to avoid destruction in the stomach and small intestine. By protecting the drugs from degrading enzymes, the new approach could also help sustain higher drug concentrations in the bloodstream.

The altered backbone also seems to make minor changes in signals that the receptor, once activated, transmits into the cell, Gellman says. "Changing the sites of backbone modification results in different profiles of response. Building drug molecules that activate only a certain type of response might allow us to dial out undesired side effects; but that's just a hope at this point."

To date, much of the focus on drug development has concerned the external features of signaling molecules, which directly contact a receptor, Gellman says. "The traditional approach is to keep the skeleton the same and modify the surface components. Our approach is just the opposite, keep the surface components the same, and modify the skeleton. Now that it is clear that this no
'/>"/>

Contact: Sam Gellman
gellman@chem.wisc.edu
608-262-3303
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. American Chemical Societys highest honor goes to pioneer of diagnostic DNA chips
2. Compounds in saliva and common body proteins may fend off DNA-damaging chemicals
3. New method discovered to protect against chemical weapons
4. Chemical companies shore up supplement science
5. American Chemical Society podcast: Bringing medical testing to remote locales
6. Are developing heart valves sensitive to environmental chemicals?
7. Pro-Tek Chemical Releases Coupon Promotion
8. Global Fermentation Chemicals Market Research Report: Transparency Market Research
9. Class Action Lawsuit Filed on Behalf of West Virginia Residents Affected by Recent Chemical Spill
10. West Virginia Business Owners Represented in Class Action Lawsuit over Elk River Chemical Spill
11. Chemical imaging brings cancer tissue analysis into the digital age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... 2014 Tbdress.com has recently announced ... on Nov. 28, 2014. The special offer will provide ladies ... is one of the world’s largest women’s dresses retailers, and ... People can enjoy great discounts on that day: Everything at ... delivery (for orders above $89). , People can use the ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Locks-Magnetic.com, a ... emergency doors. Moreover, all the new products are available ... The marketing manager is proud of the new emergency ... reset automatically. And customers can choose from several colors. ... Buying high quality emergency door release is not as ...
(Date:11/23/2014)... AngelWeddingDress.com has recently updated its ... beach wedding dresses. “If you are looking for gorgeous ... soon as possible. Here you can enjoy 70% off ... , Holding a big marriage ceremony is the most ... beach wedding dress is uppermost priority. Ophelia, one of ...
(Date:11/23/2014)... OH (PRWEB) November 23, 2014 Wright ... on behalf of Ohio and West Virginia residents who ... other health disorders due to drinking C8 contaminated ... In Parkersburg, West Virginia. According to the C8 complaints, ... they either worked or lived in at least one ...
(Date:11/22/2014)... Cancer researchers in New York and Minnesota ... tunnels and the growth and spread of mesothelioma. ... the Surviving Mesothelioma website. , Doctors at Memorial ... have just released their study on tunneling nanotubes (TnTs), ... They found that mesothelioma cells contain many ...
Breaking Medicine News(10 mins):Health News:Tbdress.com Special Friday Shoes Sales Online Now 2Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 3Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 4Health News:Study Links Cellular ‘Tunnels’ to Mesothelioma Proliferation, According to Surviving Mesothelioma 2
... 14 Birner Dental Management,Services, Inc. (Nasdaq: ... its regular quarterly dividend. The Company,s board of ... cents per share of common,stock. The dividend is ... 28, 2008., Birner Dental Management Services, Inc. ...
... 14 STERIS Corporation,(NYSE: STE ) today ... the,purchase of up to $300 million in shares ... of outstanding shares as of,February 29, 2008. This ... approximately $160 million remaining. Through March,13, 2008, the ...
... Cookie Company Adds High-Fiber Line to its Selection ... of ... Cookie,Company introduced today its new line of "Nana,s Fiber Cookie Bars." ... a moist,and delicious cookie. The new Fiber Bar will complement the ...
... PHILADELPHIA A compound found in soybeans almost completely prevented ... a study published in the March 15 issue of Cancer ... , Researchers say that the amount of ... experiments was no higher than what a human would eat ...
... Famous and Everyday Moms Share Their Own Words of Wisdom, ... Win One-of-a-Kind Keepsake Book at LifesBestDays.com, CHICAGO, March 13 ... Quaker(R) Life(R) Cereal is introducing a little life,inspiration. With the ... inspiring moms to share how they make the most of ...
... Encourages ... The Community, NEW YORK, March 13 The Stay Strong ... Starts With,Us." On the heels of Terrie M. Williams, latest book, ... movement aimed to provide,a support network that encourages open dialogue about ...
Cached Medicine News:Health News:STERIS Corporation Announces New $300 Million Share Repurchase Authorization 2Health News:STERIS Corporation Announces New $300 Million Share Repurchase Authorization 3Health News:Have Your Cookie and Fiber too With Nana's Newest Cookie Bar 2Health News:Soy compound may halt spread of prostate cancer 2Health News:Soy compound may halt spread of prostate cancer 3Health News:Quaker(R) Life(R) Cereal Partners with Actress and Mom Holly Robinson Peete to Inspire Moms to Make Their Best Days Happen 2Health News:Quaker(R) Life(R) Cereal Partners with Actress and Mom Holly Robinson Peete to Inspire Moms to Make Their Best Days Happen 3Health News:The Stay Strong Foundation Launches National 'Healing Starts With US' Campaign With Celebrity Guests Denzel Washington, Ruby Dee, Mo'Nique, Terry McMillan, Rev. Al Sharpton and Others 2Health News:The Stay Strong Foundation Launches National 'Healing Starts With US' Campaign With Celebrity Guests Denzel Washington, Ruby Dee, Mo'Nique, Terry McMillan, Rev. Al Sharpton and Others 3
(Date:11/21/2014)... , Nov. 20, 2014  RedRick Technologies, ... solutions and reading room environment guidance, has helped ... musculoskeletal radiology reading room, which may also serve ... at Penn Medicine. "In line ... American College of Radiology,s Imaging 3.0 ™ ...
(Date:11/21/2014)... Calif. , Nov. 20, 2014  The ... at the 2014 AAGL Global Congress demonstrates continued ... insert designed to provide bowel control. One of the ... Associate Professor and Division Chief of Urogynecology and ... Carolina, won an Award for Best Written Abstract ...
(Date:11/21/2014)... Calif. , Nov. 20, 2014 Depomed, Inc. (NASDAQ: ... at the Piper Jaffray 26 th Annual Healthcare Conference in ... at the Piper Jaffray conference is scheduled for 8:00 am EST ... be webcast, and the webcast can be accessed via the Investor ... recording of the webcast will be archived for 30 days on ...
Breaking Medicine Technology:RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 3LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 2LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 3Depomed To Present At Piper Jaffray 26th Annual Healthcare Conference 2
... Nfocus Neuromedical, Inc., an innovative medical device company with ... aneurysms, announced today that its Luna™ Aneurysm Embolization System ... with brain aneurysms.  The Luna AES is designed to ... brain aneurysms both pre- and post-rupture.   ...
... A recently published study in Nutrition Research and ... verified the anti-inflammatory effects in humans of Oligonol® lychee ... and related cytokines in healthy young men.  Both cortisol ... when stress such as exercise is caused on the ...
Cached Medicine Technology:Nfocus Neuromedical, Inc. Luna™ Aneurysm Embolization System Receives CE Mark 2Recent Study Demonstrates Anti-Inflammatory Properties of Oligonol® Lychee Fruit Polyphenols in Humans 2
... Technologies compact and powerful Parisian Peel ESPRIT ... safety features for simplified skin care practice. ... designed to meet strict medical device standards ... power in a compact design. The ...
... RTVue is an ultra-high speed, high ... used for retina imaging and analysis. ... generation Fourier-Domain Optical Coherence technology just emerging ... years. The ultra-high speed and ...
For the qualitative detection of IgG/IgM antibodies to B. burgdorferi...
The Clearview hCG Test is for the rapid detection of human chorionic gonadotropin (hCG) in urine specimens. This test kit is used to obtain a visual, qualitative result and is intended for professio...
Medicine Products: