Navigation Links
Chemical strategy hints at better drugs for osteoporosis, diabetes
Date:6/16/2014

MADISON, Wis. By swapping replacement parts into the backbone of a synthetic hormone, UWMadison graduate student Ross Cheloha and his mentor, Sam Gellman, along with collaborators at Harvard Medical School, have built a version of a parathyroid hormone that resists degradation in laboratory mice. As a result, the altered hormone can stay around longer and at much higher concentration, says Gellman, professor of chemistry at the UW.

Hormones are signaling molecules that are distributed throughout the body, usually in the blood. Hormones elicit responses from only those cells that carry appropriate receptor molecules. "Receptors have evolved to recognize a very specific signal in a sea of biological fluids that is full of molecular messages," Gellman says.

The relationship between a receptor and its signaling molecule is often likened to that between a lock and a key.

"We're excited because we have preserved the ability to activate the receptor" by altering the backbone of the hormone, which holds the essential contact points in place, Gellman says. "While retaining, even enhancing, the signaling ability, we have diminished the peptide's susceptibility to the biodegradation mechanisms that nature uses to eliminate signals over time."

Peptides are segments of proteins. Peptide hormones, like the better-known steroid hormones such as estrogen and testosterone, can convey a signal to billions of cells at once, even at tiny concentrations.

For a study published June 15 in Nature Biotechnology, the researchers altered a highly successful synthetic parathyroid hormone called teriparatide, which is used to combat severe osteoporosis.

But the real excitement of the discovery is the potential impact on a large class of peptide drugs, Gellman says. "A substantial group of receptors, including some involved in diabetes, respond to peptide signals, but peptides are quickly degraded in the body. Our appro
'/>"/>

Contact: Sam Gellman
gellman@chem.wisc.edu
608-262-3303
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. American Chemical Societys highest honor goes to pioneer of diagnostic DNA chips
2. Compounds in saliva and common body proteins may fend off DNA-damaging chemicals
3. New method discovered to protect against chemical weapons
4. Chemical companies shore up supplement science
5. American Chemical Society podcast: Bringing medical testing to remote locales
6. Are developing heart valves sensitive to environmental chemicals?
7. Pro-Tek Chemical Releases Coupon Promotion
8. Global Fermentation Chemicals Market Research Report: Transparency Market Research
9. Class Action Lawsuit Filed on Behalf of West Virginia Residents Affected by Recent Chemical Spill
10. West Virginia Business Owners Represented in Class Action Lawsuit over Elk River Chemical Spill
11. Chemical imaging brings cancer tissue analysis into the digital age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... (PRWEB) August 21, 2014 Improv performers ... entertained residents with dementia at Silverado Turtle Creek memory ... which consists of entertainers ranging from ages 10 to ... they perform their 40-minute set. The troupe's philosophy is ... universal and allows them to touch audiences regardless of ...
(Date:8/21/2014)... 21, 2014 (HealthDay News) -- Black mothers are less ... here,s one possible reason why: Hospitals in neighborhoods with ... those in areas with more white residents, a U.S. ... are much less common in medical centers where the ... U.S. Centers for Disease Control and Prevention reported Thursday. ...
(Date:8/21/2014)... Honolulu (PRWEB) August 21, 2014 ... its 10th anniversary and a national voice in ... leaders in health disparities during the 112th National ... , Distinguished honorees included: , John Ruffin, Ph.D, ... Health and Health Disparities, whose life-long career and ...
(Date:8/21/2014)... do not routinely screen women for intimate partner ... public health researchers. Rural women who are exposed ... seek help., "Rural health care providers are uniquely ... a primary care physician and assistant professor of ... of Medicine. "However, in rural settings, it might ...
(Date:8/21/2014)... August 21, 2014 The report ... by Pollutant Control System (FGD, DeNOx, Particulate Control, ... & Steel, Chemical & Others) - Global Trends ... global industrial flue gas treatment systems & services ... market size in terms of value. The industrial ...
Breaking Medicine News(10 mins):Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2Health News:Racial Disparities in Breast-Feeding May Start With Hospitals, Study Suggests 2Health News:W. Montague Cobb/NMA Health Institute Honors Three Outstanding Leaders in Health Disparities 2Health News:Primary care physicians can be critical resource for abused women in rural areas 2Health News:Industrial Flue Gas Treatment Systems Market Estimated to Worth $59, 546.7 Million by 2019 – Report by MarketsandMarkets 2Health News:Industrial Flue Gas Treatment Systems Market Estimated to Worth $59, 546.7 Million by 2019 – Report by MarketsandMarkets 3Health News:Industrial Flue Gas Treatment Systems Market Estimated to Worth $59, 546.7 Million by 2019 – Report by MarketsandMarkets 4
... guiding injured workers back to full-time employment should factor ... research suggests. , Workers who are injured on ... if their schedules routinely require them to work extended ... who work more than 12 hours per day or ...
... Supplementation tied to a 23% reduced risk of falling in ... Vitamin D2 supplements may help reduce the risk of falls ... of women older than 65 fall each year, and six ... In addition, fear of falling is a major problem in ...
... the lungs of patients diagnosed with idiopathic pulmonary ... of Cincinnati (UC) researchers have discovered. , According ... (pronounced new-tro-fil) cellsa type of white blood cellin ... increased risk of mortality in the first year ...
... and M&A activity in the,life sciences and healthcare sector ... more in 2008. CEOs, CFO,s and other business executives ... be,joined by some of the most sophisticated investors in ... Healthcare, April 30-May 1, 2008,in Chicago., Deal volume ...
... for ... Women, ST. ... causes nearly 2,400 deaths each day,in the United States, an average of ... 25 percent of the total U.S.,female population, there,s more reason than ever ...
... Enrollment Process, SAN JOSE, Calif., Jan. 16 ... 47 million uninsured in America are,eligible for government-sponsored ... Health Coverage Education (FHCE) has captured, on a,single ... people in need of health coverage., Combined ...
Cached Medicine News:Health News:Extended work hours should factor into return to job after injury 2Health News:Extended work hours should factor into return to job after injury 3Health News:Vitamin D May Curb Falls in High-Risk Older Women 2Health News:Rare lung disease cells indicate higher death risk 2Health News:Healthcare M&A Activity on the Rise 2Health News:Women May Enjoy Boost of Heart Health With Soy 2Health News:Internet Comes to Rescue of 14 Million Uninsured in U.S.; Providing Access to Gov. Health Programs They're Not Aware of 2Health News:Internet Comes to Rescue of 14 Million Uninsured in U.S.; Providing Access to Gov. Health Programs They're Not Aware of 3
(Date:8/21/2014)... Aug. 21, 2014 CVS Caremark Corporation (NYSE: ... Reference Yields and consideration payable in connection with its previously ... 7, 2014 for (1) any and all of its 6.250% ... (2) up to a maximum amount of its 6.125% Senior ... Senior Notes due 2017 (collectively, the "Maximum Tender Offer Notes" ...
(Date:8/21/2014)... 21, 2014 Professional Compounding Centers of ... by awarding the three best scientific presentations at ... conference . The Formulating Better Medicines for ... Athens, Greece , includes dozens ... professionals, from which three winners will be selected ...
(Date:8/21/2014)... 2014   Royal Philips (NYSE: ... has received 510(k) clearance from the U.S. Food ... application for Transcatheter Aortic-Valve Implantation (TAVI) treatments. Through ... with pre-procedural, high-precision positioning to treat aortic stenosis ... is available as part of Philips IntelliSpace ...
Breaking Medicine Technology:CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 2CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 3CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 4CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 5CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 6Professional Compounding Centers of America will award top poster-session winners at European Paediatric Formulation Initiative in Athens 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 3
... Dec 13, 2011 MedEfficiency, Inc., a medical ... manufacturing, and marketing of medical devices for treating ... that it has been awarded a Veteran,s Administration ... will be listed as a government-approved vendor.  ...
... More than 60,000 young children end up in emergency ... parents or caregivers were not looking. To remind parents ... the Centers for Disease Control and Prevention (CDC) and ... partnership with the PROTECT Initiative , today launched ...
Cached Medicine Technology:MedEfficiency Awarded VA Contract for Its Total Contact Casting Products 2CDC and CHPA Educational Foundation Launch Up and Away and Out of Sight 2CDC and CHPA Educational Foundation Launch Up and Away and Out of Sight 3
... of fibre bronchoscopy: The HF-compatible V series ... other fibre bronchoscopes are measured., ,The ... including the FB-19TV, FB-18V and FB-15V models ... the pediatric FB-8V, offer much better image ...
... Fujinon's therapeutic fiberoptic bronchoscopes ... operating channel with a ... large channel allows for ... passage of cytology brushes. ...
... performance fiberoptic imaging from the latest ... improved its fiberscope range, focussing on ... enhanced image performance. Olympus has a ... diagnosis and therapy in the respiratory ...
Large, bright images from a bronchoscope designed for routine examination and treatment....
Medicine Products: