Navigation Links
Chemical signature of manic depression discovered by scientists
Date:2/5/2008

People with manic depression have a distinct chemical signature in their brains, according to a new study. The research, published today in the journal Molecular Psychiatry, may also indicate how the mood stabilisers used to treat the disorder counteract the changes in the brain that it appears to cause.

Manic depression, which is also known as bipolar disorder, is a debilitating psychiatric condition characterised by alternating mania and depression, affecting about one in every hundred people worldwide. Although it is known that the condition can be treated relatively effectively using the mood-stabilising drugs lithium and valproic acid, the reasons why these treatments work are poorly understood.

The authors of the new study, from Imperial College London, the University of Cambridge, and the National Institutes of Mental Health in the US, hope that their research will enable a better understanding of the condition and of how it can be treated.

The researchers compared postmortem brain tissue samples of people with manic depression with those of age and gender matched controls. The samples were taken from the dorsolateral prefrontal cortex, which controls the processes involved in higher cognitive functioning. The researchers analysed these samples using Nuclear Magnetic Resonance spectroscopy and found that people with manic depression had different concentrations of chemicals in this area of the brain than those without.

The researchers also used rat models to see the effects of lithium and valproic acid on the metabolite makeup of non-bipolar brain tissue. They found that these drugs caused the opposite chemical changes to those seen in the bipolar brain tissue samples. Chemicals that were increased in the bipolar brain tissue were decreased in rats given the mood stabilising drugs, and vice versa.

The researchers findings lead them to believe that an upset in the balance of different neurotransmitters know
'/>"/>

Contact: Abigail Smith
abigail.smith@imperial.ac.uk
44-020-759-46701
Imperial College London
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Chemical chaperone could open door to treatment of neurological disorder
2. Chemical Linked to Reproductive Harm Is Getting Into Babies From Shampoo, Lotion and Powder, New Study Suggests
3. American Chemical Societys Weekly PressPac -- Jan. 30, 2008
4. Many Babies Exposed to Chemicals
5. Heating Plastic Bottles Releases Potentially Harmful Chemical
6. Hot liquids release potentially harmful chemicals in polycarbonate plastic bottles
7. American Chemical Societys weekly PressPac -- Jan. 23, 2008
8. From Research to Practice: Healthfitness, Eastman Chemical Company Case Study Demonstrates Real-World Health Gains and Productivity Savings
9. Herons persist in Chicago wetlands despite exposure to banned chemicals
10. Sleep chemical central to effectiveness of deep brain stimulation
11. Results promising for computational quantum chemical methods for drug development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2010)... Age, gender, genetics affect odds of remaining recurrence-free, research ... U.S. scientists have discovered there are genetic profiles that ... cancers, and those profiles differ depending on the age ... genetic and clinical data from 787 patients who were ... or above age 70). The findings are published in ...
(Date:2/9/2010)... folic acid, high blood pressure restrict fetal growth, study ... lifestyle habits you bring into pregnancy can have lasting ... A Dutch study found that women who smoked, had ... early pregnancy had babies that were smaller in the ... of complications later. , "Our study demonstrates that several ...
(Date:2/9/2010)... The following statement is ... M.D., President, American Medical Association: ,, (Logo: ... Medical Association is pleased to support First ... Let,s Move Campaign. As the nation,s largest ... address obesity and are committed to reenergizing ...
(Date:2/9/2010)... in captivity primarily for their skins, but some restaurants ... A study shows that eating these animals can have ... eating this ,delicacy., , Parasites, bacteria and viruses, and ... residues of veterinary drugs- eating reptile meat can cause ... a study published in the International Journal of ...
(Date:2/9/2010)... Dr. Franois Robert, a researcher at the Institut de ... team of Dr. Daniel Durocher (Samuel Lunenfeld Research Institute ... mapped all the fragile sites of a living organism, ... used by the researchers can be applied to humans. ... scientific journal Nature Structural and Molecular Biology . ...
Breaking Medicine News(10 mins):Health News:Genes Play Role in Prognosis With Non-Small Cell Lung Cancers 2Health News:Mom's Lifestyle in Early Pregnancy Affects Baby's Size 2Health News:Mom's Lifestyle in Early Pregnancy Affects Baby's Size 3Health News:Study carried out into biological risks of eating reptiles 2Health News:Researchers map all the fragile sites of the yeast Saccharomyces cerevisiae's genome 2Health News:Researchers map all the fragile sites of the yeast Saccharomyces cerevisiae's genome 3
... study neurosurgeons say they are now convinced that helmets ... the past have suggested wearing helmets during a motorcycle ... of skull base and cervical-spine (or neck) injuries secondary ... researchers to study whether helmets harm or hurt adolescent ...
... women with leukemia who died after receiving a bone marrow ... shows evidence of the transplanted // cells up to six ... marrow cells were actually acting as stem cells -- basic ... the body, and once thought to be found only in ...
... by adding more calcium to the diet may help reduce ... ,In a study of more than 95,000 women who never ... the eight years of the study. Women who consumed the ... stones compared to women who consumed the least amount. The ...
... United States. Investigators have been tracking the health of men and ... factors might impact their risk for heart disease and stroke. In ... and without a history of stroke.About 20 percent of the people ... of those who didn’t have a stroke. ,A good way ...
... suffer a stroke. About one-third of those strokes are recurrent. ... that consume lots of energy, such as dressing, bathing, walking ... survivors should be urged to exercise more at least 20 ... can help reduce the risk of another stroke. Strength training, ...
... a human papillomavirus ( HPV ) vaccination with cervical cancer ... all cervical cancers. According to a recent study it was ... caused by HPV, and 9 percent are preceded by persistent ... detect cervical cancer but it is not available to all ...
Other Medicine News:
(Date:2/9/2010)... Feb. 9 Palatin Technologies, ... the completion of first cohort dosing in a ... treatment for sexual dysfunction.  The primary endpoint in ... pressure effects of subcutaneous bremelanotide in men between ... also evaluate consistency of plasma exposure of bremelanotide ...
(Date:2/9/2010)... LAUSANNE , Switzerland , February ... Swiss-based global biopharmaceutical group of companies with,a ... that target unmet medical,needs, today announced the ... for the development, manufacture and commercialisation of ... inhibitor with a,potent anti-hepatitis C virus (HCV) ...
(Date:2/8/2010)... Calif. , Feb. 8 PreXion, ... quality 3D Cone Beam Imaging systems for dentistry, today ... as Director of Marketing. ,, PreXion President/COO ... Keith on our senior management team and I look ... extensive sales and marketing leadership, experience and success in ...
Breaking Medicine Technology:Palatin Technologies, Inc. Announces Dosing of Subcutaneous Bremelanotide Trial in Men 2Palatin Technologies, Inc. Announces Dosing of Subcutaneous Bremelanotide Trial in Men 3Palatin Technologies, Inc. Announces Dosing of Subcutaneous Bremelanotide Trial in Men 4Debiopharm Group Grants an Exclusive Licence for the Development, Manufacture and Commercialisation of Debio 025 2Debiopharm Group Grants an Exclusive Licence for the Development, Manufacture and Commercialisation of Debio 025 3PreXion, Inc. Announces Appointment of Director of Marketing 2Icahn Indicates That Biogen Board Refuses To Close Polls 12450 1MDCT angiography leads to successful treatment of severely blocked arteries in the legs 47804 1Biologists consider unifying framework to explain evolutionary puzzles 8709 1Biologists consider unifying framework to explain evolutionary puzzles 8709 2
... Inc. (OTC Bulletin Board: PLCSF), a company focused on ... that the first data from its pilot safety trial ... at the American College of Cardiology Annual Conference, on ... Florida. The poster will be presented by Dr. ...
... Abstracts Will Be Featured at Annual Kidney Care MeetingEL ... provider of kidney care services for those diagnosed with ... DaVita Clinical Research(R), today announced that company representatives will ... Spring Clinical Meetings scheduled for March 25-29, 2009 in ...
Other Medicine Technology:RenalGuard(R) Pilot Safety Clinical Trial Data to be Presented at ACC 2009 2RenalGuard(R) Pilot Safety Clinical Trial Data to be Presented at ACC 2009 3DaVita Abstracts Accepted Into National Kidney Foundation's 2009 Spring Symposium 2DaVita Abstracts Accepted Into National Kidney Foundation's 2009 Spring Symposium 3DaVita Abstracts Accepted Into National Kidney Foundation's 2009 Spring Symposium 4DaVita Abstracts Accepted Into National Kidney Foundation's 2009 Spring Symposium 5
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features:Eppendorf "pipette/tip" system ensures utmost accuracy ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
Medicine Products: