GABA and related therapies will have to be tested in human clinical trials before they can be considered as a new treatment for Type 1 diabetes, said Dr. Wang.
"GABA is the first agent to act both by protecting the insulin-producing cells from damage and by decreasing the body's immune reaction against these cells," said Dr. Gary F. Lewis, incoming director of the Banting and Best Diabetes Centre and Director of the Division of Endocrinology and Metabolism at the University of Toronto, where insulin was discovered 90 years ago.
"The body's immune reaction against its own insulin-producing cells is responsible for most of the damage that leads to the development of type 1 diabetes. This exciting observation may open up new avenues for the prevention and treatment of Type 1 diabetes in humans."
Drs. Wang and Prud'homme are both clinician scientists in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital. In addition, Dr. Wang is an associate professor in the Department of Physiology at the University of Toronto and Dr. Prud'homme is a professor in the university's Department of Laboratory Medicine and Pathobiology.
"Diabetes research such as this brings us closer to a cure," said Michael Cloutier, president and CEO at the Canadian Diabetes Association. "We are excited to be a part of this significant discovery and look forward to the outcomes of clinical studies."
|Contact: Leslie Shepherd|
St. Michael's Hospital