Navigation Links
Chemical produced in pancreas prevented and reversed diabetes in mice
Date:6/28/2011

TORONTO, Ont., June 28, 2011A chemical produced by the same cells that make insulin in the pancreas prevented and even reversed Type 1 diabetes in mice, researchers at St. Michael's Hospital have found.

Type 1 diabetes, formerly known as juvenile diabetes, is characterized by the immune system's destruction of the beta cells in the pancreas that make and secrete insulin. As a result, the body makes little or no insulin.

The only conventional treatment for Type 1 diabetes is insulin injection, but insulin is not a cure as it does not prevent or reverse the loss of beta cells.

A team led by Dr. Qinghua Wang, in the division of endocrinology and metabolism, and Dr. Gerald Prud'homme, in the division of pathology, has studied the role of GABA, or gamma-aminobutyric acid, an amino acid produced by beta cells in the pancreas. The research was funded by the Canadian Institutes of Health Research, the Juvenile Diabetes Research Foundation and the Canadian Diabetes Association.

The researchers found that GABA injections not only prevented diabetes in mice, but even reversed the disease. Their findings were published in the journal Proceedings of the National Academy of Sciences.

The significance of GABA is that it corrects both known causes of Type 1 diabetes in mice: It works in the pancreas to regenerate insulin-producing beta cells and it acts on the immune system to stop the destruction of those cells. Those two actions are necessary to reverse the disease and prevent its recurrence. Until now, there has been no effective treatment that achieves both goals at the same time.

GABA has been known for decades to be a key neurotransmitter in the brain, a chemical that nerve cells use to communicate with each other, but its role in the pancreas was unknown. The St. Michael's study is the first to identify and describe GABA's importance in regulating the survival and function of pancreatic beta cells in mice.

GABA and related therapies will have to be tested in human clinical trials before they can be considered as a new treatment for Type 1 diabetes, said Dr. Wang.

"GABA is the first agent to act both by protecting the insulin-producing cells from damage and by decreasing the body's immune reaction against these cells," said Dr. Gary F. Lewis, incoming director of the Banting and Best Diabetes Centre and Director of the Division of Endocrinology and Metabolism at the University of Toronto, where insulin was discovered 90 years ago.

"The body's immune reaction against its own insulin-producing cells is responsible for most of the damage that leads to the development of type 1 diabetes. This exciting observation may open up new avenues for the prevention and treatment of Type 1 diabetes in humans."

Drs. Wang and Prud'homme are both clinician scientists in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital. In addition, Dr. Wang is an associate professor in the Department of Physiology at the University of Toronto and Dr. Prud'homme is a professor in the university's Department of Laboratory Medicine and Pathobiology.

"Diabetes research such as this brings us closer to a cure," said Michael Cloutier, president and CEO at the Canadian Diabetes Association. "We are excited to be a part of this significant discovery and look forward to the outcomes of clinical studies."


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Related medicine news :

1. Chemical tags likely to affect metabolism, cancer development
2. NutriLuxe Offers Personal, At-Home Body Biochemical Balance Test
3. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
4. Researchers discover chemical that may protect hearts of muscular dystrophy patients
5. SRI International Researchers to Present Work on Early Detection Tool for Neglected Tropical Diseases at 2010 American Chemical Society (ACS) Meeting
6. Workplace Chemicals May Boost Breast Cancer Risk
7. Exposure to 3 classes of common chemicals may affect female development
8. ACS Webinar features tips for finding and building a career in public policy and chemical industry
9. Chemicals in Beauty Products Tied to Early Puberty in Girls
10. FDA to Re-examine Anti-Bacterial Chemical in Soaps, Cleansers
11. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... Marshall Votta, Josh Holmes and Laura ... development roles to drive RowdMap Inc.’s market growth across both health plans and provider ... order to succeed in value based care. , Marshall Votta joins RowdMap, Inc. as ...
(Date:5/1/2016)... , ... May 01, 2016 , ... ProBrand Reveal Volume 2 is a set of ... ProBrand Reveal Volume 2 keyframeless animations, users can easily create a unique logo reveal in ... feel of the various presets. Use these title presets to add a uniquely animated logo ...
(Date:4/30/2016)... ... April 30, 2016 , ... ... Talk Radio with Hypnotherapist, Mary O'Maley. What is hypnosis and hypnotherapy and ... (substances, smoking, weight control), pain relief (chronic and acute), birthing processes and medical ...
(Date:4/30/2016)... Santa Rosa, CA (PRWEB) , ... April 30, 2016 , ... “Aging well is a challenge for all of us, ... says NCMA’s Dr. Parul T. Kohli . “Research is showing more and more that ... the risk of disease and disability as we age.” Top priorities Dr. Kohli’s recommends for her ...
(Date:4/29/2016)... ... April 29, 2016 , ... Since launching ... national charitable foundation serving the footwear industry, has broken all previous participation records ... 130 companies across 23 states during the months of April and May, the ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... Jersey , April 29, 2016 ... Suite for Life Sciences, Product Development Capabilities in ... Life Science Customer Base . ... provider, today announced the acquisition of Skura Corporation,s ... global leader in adaptive sales enablement technology for ...
(Date:4/29/2016)... 2016 Automation is one of ... to the growing demands for productivity in speed, accuracy, ... systems are already adept of a wide range of ... manual labor. Instrumentation continues to evolve, and is poised ... a few years ago. Originally used mostly by the ...
(Date:4/28/2016)... -- Research and Markets has announced the ... 2016-2020" report to their offering.      ... global plastic surgery products market is expected to grow ... , ,The growing adoption of laser in aesthetics is ... market. Lasers are used to treat a broad range ...
Breaking Medicine Technology: