Navigation Links
Chemical produced in pancreas prevented and reversed diabetes in mice
Date:6/28/2011

TORONTO, Ont., June 28, 2011A chemical produced by the same cells that make insulin in the pancreas prevented and even reversed Type 1 diabetes in mice, researchers at St. Michael's Hospital have found.

Type 1 diabetes, formerly known as juvenile diabetes, is characterized by the immune system's destruction of the beta cells in the pancreas that make and secrete insulin. As a result, the body makes little or no insulin.

The only conventional treatment for Type 1 diabetes is insulin injection, but insulin is not a cure as it does not prevent or reverse the loss of beta cells.

A team led by Dr. Qinghua Wang, in the division of endocrinology and metabolism, and Dr. Gerald Prud'homme, in the division of pathology, has studied the role of GABA, or gamma-aminobutyric acid, an amino acid produced by beta cells in the pancreas. The research was funded by the Canadian Institutes of Health Research, the Juvenile Diabetes Research Foundation and the Canadian Diabetes Association.

The researchers found that GABA injections not only prevented diabetes in mice, but even reversed the disease. Their findings were published in the journal Proceedings of the National Academy of Sciences.

The significance of GABA is that it corrects both known causes of Type 1 diabetes in mice: It works in the pancreas to regenerate insulin-producing beta cells and it acts on the immune system to stop the destruction of those cells. Those two actions are necessary to reverse the disease and prevent its recurrence. Until now, there has been no effective treatment that achieves both goals at the same time.

GABA has been known for decades to be a key neurotransmitter in the brain, a chemical that nerve cells use to communicate with each other, but its role in the pancreas was unknown. The St. Michael's study is the first to identify and describe GABA's importance in regulating the survival and function of pancreatic beta cells in mice.

GABA and related therapies will have to be tested in human clinical trials before they can be considered as a new treatment for Type 1 diabetes, said Dr. Wang.

"GABA is the first agent to act both by protecting the insulin-producing cells from damage and by decreasing the body's immune reaction against these cells," said Dr. Gary F. Lewis, incoming director of the Banting and Best Diabetes Centre and Director of the Division of Endocrinology and Metabolism at the University of Toronto, where insulin was discovered 90 years ago.

"The body's immune reaction against its own insulin-producing cells is responsible for most of the damage that leads to the development of type 1 diabetes. This exciting observation may open up new avenues for the prevention and treatment of Type 1 diabetes in humans."

Drs. Wang and Prud'homme are both clinician scientists in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital. In addition, Dr. Wang is an associate professor in the Department of Physiology at the University of Toronto and Dr. Prud'homme is a professor in the university's Department of Laboratory Medicine and Pathobiology.

"Diabetes research such as this brings us closer to a cure," said Michael Cloutier, president and CEO at the Canadian Diabetes Association. "We are excited to be a part of this significant discovery and look forward to the outcomes of clinical studies."


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Related medicine news :

1. Chemical tags likely to affect metabolism, cancer development
2. NutriLuxe Offers Personal, At-Home Body Biochemical Balance Test
3. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
4. Researchers discover chemical that may protect hearts of muscular dystrophy patients
5. SRI International Researchers to Present Work on Early Detection Tool for Neglected Tropical Diseases at 2010 American Chemical Society (ACS) Meeting
6. Workplace Chemicals May Boost Breast Cancer Risk
7. Exposure to 3 classes of common chemicals may affect female development
8. ACS Webinar features tips for finding and building a career in public policy and chemical industry
9. Chemicals in Beauty Products Tied to Early Puberty in Girls
10. FDA to Re-examine Anti-Bacterial Chemical in Soaps, Cleansers
11. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
Breaking Medicine Technology: