Navigation Links
Chemical imaging brings cancer tissue analysis into the digital age
Date:1/8/2014

A new method for analysing biological samples based on their chemical makeup is set to transform the way medical scientists examine diseased tissue. When tests are carried out on a patient's tissue today, such as to look for cancer, the test has to be interpreted by a histology specialist, and can take weeks to obtain a full result.

Mass spectrometry imaging (MSI) uses technologies that reveal how hundreds or thousands of chemical components are distributed in a tissue sample. Scientists have proposed using MSI to identify tissue types for many years, but until now, no method has been devised to apply such technology to any type of tissue.

In this week's Proceedings of the National Academy of Sciences, researchers at Imperial College London have outlined a recipe for processing MSI data and building a database of tissue types.

In MSI, a beam moves across the surface of a sample, producing a pixelated image. Each pixel contains data on thousands of chemicals present in that part of the sample. By analysing many samples and comparing them to the results of traditional histological analysis, a computer can learn to identify different types of tissue.

A single test taking a few hours can provide much more detailed information than standard histological tests, for example showing not just if a tissue is cancerous, what the type and sub-type of cancer, which can be important for choosing the best treatment. The technology can also be applied in research to offer new insights into cancer biology.

Dr. Kirill Veselkov, corresponding author of the study from the Department of Surgery and Cancer at Imperial College London, said: "MSI is an extremely promising technology, but the analysis required to provide information that doctors or scientists can interpret easily is very complex. This work overcomes some of the obstacles to translating MSI's potential into the clinic. It's the first step towards creating the next generation of fully automated histological analysis."

Dr. Zoltan Takats, from the Department of Surgery and Cancer at Imperial College London, said: "This technology can change the fundamental paradigm of histology. Instead of defining tissue types by their structure, we can define them by their chemical composition. This method is independent of the user it's based on numerical data, rather than a specialist's eyes and it can tell you much more in one test than histology can show in many tests."

Professor Jeremy Nicholson, Head of the Department of Surgery and Cancer at Imperial College London, said: "There have been relatively few major changes in the way we study tissue sample pathology since the late 19th century, when staining techniques were used to show tissue structure. Such staining methods are still the mainstay of hospital histopathology; they have become much more sophisticated but they are slow and expensive to do and require considerable expertise to interpret.

"Multivariate chemical imaging that can sense abnormal tissue chemistry in one clean sweep offers a transformative opportunity in terms of diagnostic range, speed and cost, which is likely to impact on future pathology services and to improve patient safety."

The technology will also be useful in drug development. To study where a new drug is absorbed in the body, pharmaceutical scientists attach a radioactive label to the drug molecule, then look at where the radiation can be detected in a laboratory animal. If the label is detached when the drug is processed in the body, it is impossible to determine how and where the drug has been metabolised. MSI would allow researchers to look for the drug and any metabolic products in the body, without using radioactive labels.


'/>"/>
Contact: Sam Wong
sam.wong@imperial.ac.uk
44-207-594-2198
Imperial College London
Source:Eurekalert

Related medicine news :

1. Water Treatment Chemicals Procurement Research Report Now Available from IBISWorld
2. RSNA: Brain Chemical Ratios Help Predict Developmental Delays in Preterm Infants
3. Brain chemical ratios help predict developmental delays in preterm infants
4. Vanderbilt study: Ancient chemical bond may aid cancer therapy
5. Building life-saving batteries: American Chemical Society Prized Science video
6. Europe Seed Treatment (Chemical & Non-Chemical) Market worth $633.2 Million By 2018 - New Report by MarketsandMarkets
7. GUMBOS promise new drugs and electronics: American Chemical Society Prized Science video
8. South Florida Company, Lice Troopers Has an All-natural Cure for Head Lice as 60 percent of lice are resistant to chemicals
9. Promoting chemistry through cooking: American Chemical Society Prized Science video
10. Laguna Beach Cockroaches Prompt Closure of Donut Store; My Cleaning Products Shares a Trick How to Get Rid of Roaches without Harsh Chemical's Help
11. Specialty Technical Publishers Launches Free eBook Series On Safe Hazardous Chemical Management
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... 2016 , ... Research has shown that building shame resilience ... and level of relapse. , At the 2016 iaedp Symposium, the ... the critical tasks of the recovery phase and beyond including relapse prevention and ...
(Date:2/5/2016)... ... February 05, 2016 , ... Love is in the ... a variety of colors, assortments and packaging. This staple for Valentine’s Day is a ... location. , For Valentine’s Day, not only are long-stem roses available, but also ...
(Date:2/5/2016)... City, UT (PRWEB) , ... February 05, 2016 , ... ... Whole-Food Nutrition , announced that the much-anticipated feature with author Jahnavi Foster, specialist in ... Humans Amateur TV Network. , Each week, on his weekly Whole-Food Warrior TV show, ...
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held ... Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research ... Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this informative event ...
(Date:2/5/2016)... Santa Rosa, CA (PRWEB) , ... February 05, ... ... are pleased to announce the addition of micro-needling services in their Napa Valley ... appearance. The founders of Plastic Surgery Associates, Dr. Canales and Dr. Furnas, are ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
(Date:2/4/2016)... -- Omnicell, Inc. (NASDAQ: OMCL ), a leading provider of ... announced results for its fiscal year and fourth quarter ... --> GAAP results: Revenue for the fourth quarter ... 4.1% from the third quarter of 2015, and up ... 2014. Revenue for the year ended December 31, 2015 was ...
(Date:2/4/2016)... 2016  Blueprint Medicines Corporation (NASDAQ: BPMC ... selective investigational kinase medicines for patients with genomically ... board of directors of Lonnel Coats , ... of industry-related experience. Jeffrey Albers ... strong strategic experience developing and commercializing numerous oncology ...
Breaking Medicine Technology: