In protocol 2, prior to infusions, both saline and CHX groups exhibited similar significant baroreflex pressor responses to carotid occlusion. After both 1st and 2nd saline infusions, the pressor response in the control group did not differ significantly from baseline. However, in the CHX group, the pressor response was blunted after the first infusion and was undetectable after the 2nd CHX infusion. There are a myriad of neurological complications that develop in patients who undergo EC support. The relative contributions of the underlying disease vs. the treatment are often difficult to discern. Moreover, the potential contribution of CHX to the evolution of these complications has not been investigated.
In protocol 3, the wet/dry ratio of organ weights served as an index of tissue fluid retention and, thus, edema formation. The ratios for all individual organs within each treatment group were pooled to create an overall index of edema formation. The pooled ratio for the CHX group was significantly higher than the saline group.
According to Dr. Thompson-Torgerson, lead author on the paper, and Dr. Shoukas, the senior researcher on the study, "The data from this study provide a current estimate of CHX contamination in most commercially available IV bags and EC circuits. The data allowed us to determine a clinically relevant CHX exposure. A similar level of exposure in animals resulted in cardiovascular morbidities analogous to those observed following clinical EC treatment. This supports our hypothesis that CHX may contribute to EC-related cardiovascular insufficiency. However, we would never tell patients to decline EC treatment if they need it. On the contrary, EC technologies are life-saving medica
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American Physiological Society